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Find Family Hotels in Cape Girardeau, MO

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Check availability on Cape Girardeau Family Hotels

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Dec 28 - Dec 29
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Dec 29 - Dec 30
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Jan 2 - Jan 4
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Jan 9 - Jan 11

Our top choices for Cape Girardeau family-friendly hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is ₩129,735
₩146,343 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (143)
"Nice hotel, clean and comfortable "
United States
Laura
The price is ₩126,866
₩143,124 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ₩100,902
₩113,834 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Pear Tree Inn Cape Girardeau Near the Medical Center
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is ₩152,499
₩172,040 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Cape Girardeau I 55 East
Property amenity
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (886)
"Room was clean and spacious."
United States
George
The price is ₩100,916
₩121,776 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Great stay"
United States
Heather
The price is ₩100,902
₩113,834 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Pear Tree Inn Cape Girardeau West
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (677)
"Great place "
United States
GUY
The price is ₩121,316
₩131,294 total
includes taxes & fees
Jan 7 - Jan 8, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Free daily on-the-go breakfast
Hotel 7 Inn Anna

Hotel 7 Inn Anna

Hotel 7 Inn Anna
2.5 star property
Anna
6.6 out of 10, (217)
"The staff was wonderful"
United States
Donna
The price is ₩118,072
₩136,958 total
includes taxes & fees
Dec 29 - Dec 30
Hotel 7 Inn Anna
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Frequently asked questions

What's Cape Girardeau like for family-friendly vacations?
You might want to consider the historic destination of Cape Girardeau if you've been thinking about a trip for the whole family. The restaurants here makes this an attractive vacation spot for families. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is the closest airport, or Cairo, IL (CIR-Cairo Regional), which is located 23.4 mi (37.6 km) from the city center.
What's the best accommodation for a family vacation to Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center is a hotel with an indoor pool and a restaurant, and it's a top choice on Expedia for families. Other good options for your family trip include Pear Tree Inn Cape Girardeau Near the Medical Center and Pear Tree Inn Cape Girardeau West.
When's the best time to book a family-friendly vacation in Cape Girardeau?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do with your family in Cape Girardeau?
While you and your family are visiting Cape Girardeau, you might want to check out some kid-friendly attractions such as Show Me Center, The Glenn House, and Cape Splash Family Aquatic Center. Make sure you have lots of time for activities like Cape Girardeau Conservation Nature Center and Lazy L Safari Park.