Photo by Alice Burghart

Find Pet-friendly Hotels in Cape Girardeau, MO

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Cape Girardeau Pet-friendly Hotels

Next weekend
In two weeks

Our top choices for Cape Girardeau pet-friendly hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is ₩129,735
₩146,343 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Plaza Hotel Cape Girardeau Conference Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ₩100,902
₩113,834 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Pear Tree Inn Cape Girardeau Near the Medical Center

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (104)
"It was a nice stay"
United States
Douglas
The price is ₩128,856
₩146,655 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Tru By Hilton Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1001)
"Very friendly staff and great breakfast"
United States
Ray
The price is ₩129,735
₩146,343 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Inn & Suites Cape Girardeau

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is ₩152,499
₩172,040 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Cape Girardeau I 55 East

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (886)
"Room was clean and spacious."
United States
George
The price is ₩100,916
₩121,776 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Candlewood Suites Cape Girardeau by IHG

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is ₩79,291
₩92,626 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Town House Inn Cape Giradreau

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Great stay"
United States
Heather
The price is ₩100,902
₩113,834 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ₩119,643
₩126,491 total
includes taxes & fees
Dec 29 - Dec 30
Drury Inn & Suites Jackson MO

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (84)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Cape Girardeau Hotel Reviews

Frequently asked questions

What's the best pet-friendly accommodation in Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center is a top hotel for people traveling with their pets, and offers a restaurant and free WiFi for its human guests. Other good choices to stay with your pet include Tru By Hilton Cape Girardeau and Drury Inn & Suites Cape Girardeau.
How many hotels that welcome pets are there in Cape Girardeau?
Stay with your furry friend at one of Expedia's 8 Cape Girardeau accommodations that accept pets.
What's the best time of year to travel to Cape Girardeau with my pet?
When you travel with your pet, keeping track of the weather can make the trip safe and fun for everyone. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What is there to see and do with your pet in Cape Girardeau?
Known for its riverfront and university life, Cape Girardeau has lots to offer visitors. See the local sights and visit Isle Casino Cape Girardeau and Show Me Center. While you're there, make sure you don't miss Hunter Valley Winery and Trail of Tears State Park.