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Book a flight to Middlesboro with Expedia and you'll be arriving at McGhee Tyson Airport (TYS).

A flight to Middlesboro means landing at McGhee Tyson Airport (TYS). Step off the plane, grab your luggage and you'll be 97 kilometers from the center of town.

There are 5 air carriers that fly into Middlesboro from 22 airports around the world.

Flights to Middlesboro are typically operated by Delta. The majority of these flights take off from Atlanta, with Delta servicing this route the most.

With 369 nonstop flights operating each week, you'll be touching down in Middlesboro before you can ask, "Are we there yet?"

Flights to Middlesboro departing from Atlanta, Charlotte and Washington airports are the most popular.

Which city you depart from determines how long you'll be strapped into your seat. From Atlanta to Middlesboro, the average flight time is 58 minutes. From Charlotte it takes about 1 hour and 14 minutes, and from Washington it's 1 hour and 51 minutes.

We all know those fortunate jet-setters who manage to pick up incredibly cheap airfares wherever they go. Would you like to know how to do it for your Middlesboro vacation? Don't leave it until the last moment to lock in your flight. Another great way to nab the most competitive fare is to shop around. If where you're headed has several airports, research the cost of flying into a smaller terminal. Finally, be ready to lock in your seat quickly if you find an irresistible price. It might not be available for too long. With a bit of know-how and a little luck, the ideal fare can be yours.

Depending on where you’re coming from, your journey to Middlesboro could be completely painless or it could drag on forever. Here are some useful tips that will help you start your next great adventure on a positive note. What to pack in your hand luggage:

• First, pack your passport, travel docs, wallet and medications. Next, you'll want some in-flight entertainment to while away the hours. A thrilling novel and a phone filled with your favorite movies are good options. If you intend to catch up on some sleep, a neck pillow and some earplugs will also be useful. Finally, leave space for a few toiletry items so you'll touchdown looking fresh and raring to go.

Do not pack the following items in your hand luggage:

• Double-check that you don't have a pocket knife lurking in one of the zippers of your carry-on luggage. Other restricted items include flammable or explosive substances, such as fuel and fireworks, and liquids and gels in containers with a volume of more than 3.4 ounces (100 milliliters).

What to wear on a flight:

• The aisles of an aircraft aren't the place for a fashion parade. Layer up with comfy clothing and pick shoes that are flat, roomy and easy to take on and off.
• Deep vein thrombosis (DVT) is a potential risk on long-haul flights. It results from blood clotting due to inactivity and poor circulation, so do some gentle leg and foot exercises in your seat and consider wearing compression socks or tights.

As savvy travelers know, the secret is to be well prepared before you arrive at airport security. That way, you'll be stepping onto that plane to Middlesboro in next to no time. Follow these helpful tips and get your trip off to a fantastic start:

• First things first. Your travel documents and passport will need to be inspected by airport security. Keep them within easy reach so you don't have to dig around for them.
• Next up, both you and your carry-on bag will be X-rayed. To make the process quick and painless, remove anything that might set the alarms off. Personal belongings like your coat, belt and headphones will be required to go through the machine.
• Electronic devices like laptops and phones will also have to go through the machine for inspection. No need to worry though, you'll be back online before you know it.
• Don't forget to remove liquids and gels from your hand luggage. They usually need to be sent through the X-ray separately. Each item should be no larger than 3.4 ounces (100 milliliters) and everything must fit inside a single quart-size (one liter), clear zip-close bag.
• There's a chance you'll need to take your shoes off to be X-rayed, so wearing lightweight sneakers is always a smart idea.
• Airlines will not allow any sharp or pointed objects in your hand luggage. If you need to bring these kinds of items, put them in your checked baggage.