Photo by Najib Tecle

Find hotels in Downtown Clayton, St. Louis from ₩113,592

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Aug 26 - Aug 27
Tomorrow
Aug 27 - Aug 28
This weekend
Aug 29 - Aug 31
Next weekend
Sep 5 - Sep 7

Filter by

Guest rating
Guest rating
Star rating

Discover 1,750 Downtown Clayton hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Moonrise Hotel
Exterior

Moonrise Hotel

4.0 star property
9.0 out of 10, Wonderful, (1854)
"Great staff, comfy room!"
The price is ₩180,483
₩214,651 total
includes taxes & fees
Sep 8 - Sep 9
Moonrise Hotel
The Principal Hotel
Exterior

The Principal Hotel

3.5 star property
9.8 out of 10, Exceptional, (124)
"Perfect stay! "
The price is ₩156,751
₩173,967 total
includes taxes & fees
Aug 27 - Aug 28
The Principal Hotel
The Knight Center at Washington University
Pub

The Knight Center at Washington University

2.5 star property
9.4 out of 10, Exceptional, (383)
"Great location and staff!"
The price is ₩186,333
₩214,261 total
includes taxes & fees
Aug 31 - Sep 1
The Knight Center at Washington University
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Property entrance

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

3.5 star property
8.4 out of 10, Very Good, (568)
"The hotel has is nice and quiet. "
The price is ₩169,520
₩201,570 total
includes taxes & fees
Aug 31 - Sep 1
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
The Ritz-Carlton, St. Louis
Meeting facility

The Ritz-Carlton, St. Louis

5.0 star property
9.2 out of 10, Wonderful, (544)
"Great place"
The price is ₩721,156
₩840,070 total
includes taxes & fees
Sep 21 - Sep 22
The Ritz-Carlton, St. Louis
Clayton Plaza Hotel & Extended Stay
Exterior

Clayton Plaza Hotel & Extended Stay

3.5 star property
8.8 out of 10, Excellent, (2918)
"Clean rooms excellent staff wonderful on site Breakfast"
The price is ₩151,804
₩176,834 total
includes taxes & fees
Sep 21 - Sep 22
Clayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton
Outdoor pool, open 8:00 AM to 8:30 PM, pool umbrellas, sun loungers

Le Méridien St. Louis Clayton

4.0 star property
8.8 out of 10, Excellent, (650)
"The property was clean with easy check in process. Stay was accommodating and friendly. Will definitely stay here again. "
The price is ₩241,608
₩283,860 total
includes taxes & fees
Sep 21 - Sep 22
Le Méridien St. Louis Clayton
AC Hotel St. Louis Clayton
2 bars/lounges, rooftop bar

AC Hotel St. Louis Clayton

3.0 star property
9.2 out of 10, Wonderful, (152)
"An amazing stay!"
The price is ₩180,636
₩210,419 total
includes taxes & fees
Sep 1 - Sep 2
AC Hotel St. Louis Clayton
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Bar (on property)

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4.0 star property
8.8 out of 10, Excellent, (1008)
"Great stay"
The price is ₩128,808
₩153,190 total
includes taxes & fees
Aug 31 - Sep 1
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Red Lion Inn & Suites Pontoon Beach
Blackout drapes, free WiFi, bed sheets

Red Lion Inn & Suites Pontoon Beach

2.5 star property
8.0 out of 10, Very Good, (498)
"The hotel was a safe place to stay and the staff were nice. The location was noisy and hotel was very bare bones. "
The price is ₩90,318
₩102,254 total
includes taxes & fees
Aug 27 - Aug 28
Red Lion Inn & Suites Pontoon Beach
Drury Plaza Hotel St. Louis Chesterfield
Exterior

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1011)
"Great place to stay! "
The price is ₩180,622
₩209,496 total
includes taxes & fees
Aug 31 - Sep 1
Drury Plaza Hotel St. Louis Chesterfield
The Cheshire
Terrace/patio

The Cheshire

4.0 star property
8.6 out of 10, Excellent, (1005)
"Great place to stay!"
The price is ₩190,210
₩225,853 total
includes taxes & fees
Sep 1 - Sep 2
The Cheshire
The Royal Sonesta Chase Park Plaza St. Louis
Seasonal outdoor pool

The Royal Sonesta Chase Park Plaza St. Louis

4.5 star property
9.0 out of 10, Wonderful, (1003)
"Very nice stay "
The price is ₩273,873
₩363,939 total
includes taxes & fees
Aug 31 - Sep 1
The Royal Sonesta Chase Park Plaza St. Louis
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Terrace/patio

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4.0 star property
8.8 out of 10, Excellent, (1010)
"Enjoyed my stay!!"
The price is ₩175,981
₩207,532 total
includes taxes & fees
Aug 30 - Aug 31
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Pear Tree Inn St. Louis Airport
Lobby

Pear Tree Inn St. Louis Airport

2.5 star property
9.4 out of 10, Exceptional, (2669)
"Great place to stay!"
The price is ₩125,042
₩147,205 total
includes taxes & fees
Sep 1 - Sep 2
Pear Tree Inn St. Louis Airport
Wingate by Wyndham St. Louis Airport
Room, 2 Queen Beds, Accessible, Non Smoking (Mobility, Tub W/Grab Bars) | Desk, laptop workspace, iron/ironing board, free cribs/infant beds

Wingate by Wyndham St. Louis Airport

2.5 star property
9.2 out of 10, Wonderful, (1405)
"Clean, comfortable and easy to get to airport "
The price is ₩152,846
₩179,958 total
includes taxes & fees
Sep 2 - Sep 3
Wingate by Wyndham St. Louis Airport
Drury Inn & Suites St. Louis Collinsville
Lobby

Drury Inn & Suites St. Louis Collinsville

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Great place to stay "
The price is ₩154,222
₩177,330 total
includes taxes & fees
Aug 31 - Sep 1
Drury Inn & Suites St. Louis Collinsville
21C Museum Hotel St Louis
Exterior

21C Museum Hotel St Louis

4.5 star property
9.0 out of 10, Wonderful, (1330)
"Amazing hotel!"
The price is ₩199,603
₩240,342 total
includes taxes & fees
Sep 1 - Sep 2
21C Museum Hotel St Louis
AC Hotel St. Louis Central West End
Lobby lounge

AC Hotel St. Louis Central West End

4.0 star property
9.0 out of 10, Wonderful, (627)
"Easy Location and nice area"
The price is ₩187,584
₩221,216 total
includes taxes & fees
Aug 30 - Aug 31
AC Hotel St. Louis Central West End
Live by Loews - St.Louis
Breakfast, lunch and dinner served

Live by Loews - St.Louis

4.0 star property
9.2 out of 10, Wonderful, (1019)
"Good hotel for the money. "
The price is ₩220,932
₩262,751 total
includes taxes & fees
Sep 1 - Sep 2
Live by Loews - St.Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown Clayton

Find the best Downtown Clayton areas and neighborhoods for the activities you enjoy most.
Meeting of the Waters Fountain showing a statue or sculpture and a fountain

Downtown St. Louis

3 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Central West End

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

St. Louis which includes interior views

Downtown West

3 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Top Downtown Clayton Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent
"Very clean, helpful staff. "
Tabitha 3-night trip
Posted 1 day ago
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Downtown Clayton?

Travelers to the Downtown Clayton neighborhood in St. Louis will be sure to enjoy their stay.

What's a favorite place to stay in Downtown Clayton?

Based on Expedia customer reviews, The Ritz-Carlton, St. Louis is the highest ranked property in Downtown Clayton. This hotel offers a restaurant and a fitness center. Other favorite options in the area include AC Hotel St. Louis Clayton and Le Méridien St. Louis Clayton.

How many hotels should I expect to find in the Downtown Clayton area?

Expedia has 6 Downtown Clayton hotels and other accommodations, and one might make a good home base for venturing out into the greater St. Louis area.

If I need to cancel my hotel reservation in Downtown Clayton, will I receive a refund?

Yes! Most hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then you can use the "fully refundable" filter to view top deals in Downtown Clayton.

Where can I learn more about changing or cancelling my trip to Downtown Clayton?

For more details about rescheduling or cancelling your trip to Downtown Clayton, go to https://www.expedia.com/service/.

What can I see and do in this St. Louis neighborhood?

Shaw Park Tennis Center, Saint Louis Galleria Mall, and Tao Tennis Center are just a few of the places to visit in and around Downtown Clayton. While you're out sightseeing, Center of Creative Arts and Chapel of St. Timothy And St. Titus, Concordia Seminary are a couple of additional sights to visit in St. Louis.

How can I get around Downtown Clayton and the greater St. Louis area?

Ready to get out and explore the city? Clayton Station is the closest metro station.