A riverside walkway with cyclists, a bridge, and modern buildings.

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Check availability on Greenville Resorts & Hotels with Spas

Tonight
Oct 10 - Oct 11
Tomorrow
Oct 11 - Oct 12
Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25

Our top choices for Greenville hotels with a spa

A spa room with two beds, a mural, and a reception desk.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
  • Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
₩522,116
₩591,558 total
includes taxes & fees
Oct 11 - Oct 12
Grand Bohemian Lodge Greenville, Autograph Collection
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A modern interior with a large window, a chandelier, a dining area, and a hallway leading to a door.
A cozy lounge area with leather armchairs, a central table, and a fireplace.
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.

2. Hotel Hartness

Hotel Hartness
Greenville
  • Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
₩241,367
₩317,697 total
includes taxes & fees
Nov 5 - Nov 6
Hotel Hartness
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A swimming pool with lounge chairs and a building with balconies.
A reception area with a wooden reception desk, a large abstract painting, and a potted plant.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.

3. Hotel Domestique

Hotel Domestique
Travelers Rest
  • Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
₩561,569
₩617,726 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Domestique
A wooden deck with chairs, surrounded by trees with autumn foliage.
A cozy room with a fireplace, a bed, a sofa, and a wooden dresser.
A dining table set for two with a view of a forested landscape through large windows.
A hotel with a covered front porch, steps leading up to the entrance, and snow-covered bushes.

4. The Orchard Inn

The Orchard Inn
Saluda
  • Enjoy a couples massage or solo Swedish retreat in this peaceful bed & breakfast with gardens and a 24-hour gym.
₩400,885
₩439,967 total
includes taxes & fees
Nov 10 - Nov 11
The Orchard Inn
View all properties

Choose what matters most at spa hotels in Greenville

Pool
Hot tub
Breakfast included
4 stars
Gym

Top Greenville Hotel Reviews

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

10/10 Excellent
"Excellent staff. Especially the housekeepers."
Ann 4-night trip
Posted 12 hours ago
La Quinta by Wyndham Haywood Mall-Near Greenville Downtown
The Westin Poinsett Greenville

The Westin Poinsett Greenville

8/10 Good
"Very clean and well kept. Water from shower was barely cold. No sauna or hot tub available. Greenville is a beautiful, clean and modern community with friendly, calming and healthy energy."
DR CLIFFORD S 6-night trip
Posted 6 days ago
The Westin Poinsett Greenville

Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your vacation. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center and a restaurant. Enjoy a massage at The Spa at Grand Bohemian. Another popular spa hotel in Greenville is Hotel Hartness.
How many spa hotels will I find in Greenville?
Among Expedia's 702 accommodation options in Greenville, there are 2 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children's Museum of the Upstate, and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Greenville Zoo and Fluor Field at the West End.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas and offer services like couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

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