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Find Resorts & Hotels with Spas in Greenville, SC

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Check prices for these dates

Tonight
Nov 13 - Nov 14
Tomorrow
Nov 14 - Nov 15
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

Our top choices for Greenville hotels with a spa

A spa room with two beds, a mural, and a reception desk.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (570 reviews)
  • cleanliness
    Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
The price is ₩466,743
₩528,819 total
includes taxes & fees
Dec 7 - Dec 8
Grand Bohemian Lodge Greenville, Autograph Collection
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.

2. Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (885 reviews)
  • cleanliness
    Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
The price is ₩243,533
₩319,929 total
includes taxes & fees
Dec 10 - Dec 11
Hotel Hartness
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.

3. Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (37 reviews)
  • cleanliness
    Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
The price is ₩558,757
₩614,633 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Domestique
A wooden deck with chairs, surrounded by trees with autumn foliage.

4. The Orchard Inn

The Orchard Inn
3.0 star property
Saluda
9.8 out of 10, Exceptional, (142 reviews)
  • cleanliness
    Enjoy a couples massage or solo Swedish retreat in this peaceful bed & breakfast with gardens and a 24-hour gym.
The price is ₩371,274
₩407,467 total
includes taxes & fees
Dec 1 - Dec 2
The Orchard Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Greenville

Pool
Hot tub

Top Greenville Hotel Reviews

A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
Hotel Hartness

Hotel Hartness

Hotel Hartness
Greenville

10/10 Excellent

The hotel is top notch. The rooms were thoughtfully decorated and there were many amenities. Breakfast was wonderful.
United States
Gracie
Reviewed April 22, 2025
Hotel Hartness

Frequently Asked Questions

Looking to vacation at a spa hotel in Greenville?

Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your vacation. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.

What is the best spa hotel in Greenville?

Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center and a restaurant. Enjoy a massage at The Spa at Grand Bohemian. Another popular spa hotel in Greenville is Hotel Hartness.

How many spa hotels will I find in Greenville?

Among Expedia's 702 accommodation options in Greenville, there are 2 spa hotels.

What's there to see and do in Greenville?

Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children’s Museum of the Upstate, and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Greenville Zoo and Fluor Field at the West End.

What is a Greenville spa hotel?

Spa hotels in Greenville have full on-site spas and offer services like couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.