Find Resorts & Hotels with Spas in Greenville, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Resorts & Hotels with Spas

Our top choices for Greenville hotels with a spa

Couples treatment rooms, body treatments, body wraps, body scrubs

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (692 reviews)
  • cleanliness
    Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
The price is ₩236,408
₩309,900 total
includes taxes & fees
Apr 26 - Apr 27
Hotel Hartness
Spa

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (472 reviews)
  • cleanliness
    Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
The price is ₩470,458
₩531,618 total
includes taxes & fees
Apr 19 - Apr 20
Grand Bohemian Lodge Greenville, Autograph Collection
Courtyard

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (33 reviews)
  • cleanliness
    Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
The price is ₩634,058
₩697,464 total
includes taxes & fees
May 7 - May 8
Hotel Domestique
View from property

The Orchard Inn

The Orchard Inn
3.0 star property
Saluda
9.4 out of 10, Exceptional, (139 reviews)
  • cleanliness
    Enjoy a couples massage or solo Swedish retreat in this peaceful bed & breakfast with gardens and a 24-hour gym.
The price is ₩410,596
₩450,622 total
includes taxes & fees
Apr 13 - Apr 14
The Orchard Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Greenville

Pool
Hot tub

Top Greenville Hotel Reviews

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

6/10 Okay
"Food was great first morning, second morning the food was a little over done bacon crumbing into little pieces. The pool was down and we had 6 kids to entertain with no pool and that’s the reason they picked Embassy for their vacation. Staff and housekeepers were great."
Diane 2-night trip
Posted 4 hours ago
Embassy Suites Greenville Golf Resort & Conference Center

Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your vacation. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center and a restaurant. Enjoy a massage at Poseidon Spa. Another popular spa hotel in Greenville is Hotel Hartness.
How many spa hotels will I find in Greenville?
Among Expedia's 668 accommodation options in Greenville, there are 3 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children's Museum of the Upstate, and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Greenville Zoo and Fluor Field at the West End.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas and offer services like couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.