A riverside walkway with cyclists, a bridge, and modern buildings.

Find Resorts & Hotels with Spas in Greenville, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Resorts & Hotels with Spas

Tonight
Oct 19 - Oct 20
Tomorrow
Oct 20 - Oct 21
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Greenville hotels with a spa

A spa room with two beds, a mural, and a reception desk.
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
  • Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
₩465,868
₩527,828 total
includes taxes & fees
Nov 15 - Nov 16
Grand Bohemian Lodge Greenville, Autograph Collection
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A cozy lounge area with leather armchairs, a central table, and a fireplace.
A modern interior with a large window, a chandelier, a dining area, and a hallway leading to a door.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

2. Hotel Hartness

Hotel Hartness
Greenville
  • Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
₩219,295
₩292,492 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Hartness
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A swimming pool with lounge chairs and a building with balconies.
A bar with a large window view of mountains and a chandelier.
A reception area with a wooden reception desk, a large abstract painting, and a potted plant.

3. Hotel Domestique

Hotel Domestique
Travelers Rest
  • Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
₩559,051
₩614,956 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Domestique
A wooden deck with chairs, surrounded by trees with autumn foliage.
A cozy room with a fireplace, a bed, a sofa, and a wooden dresser.
A wooden deck with a spiral glass sculpture, potted plants, and a bench.
A dining table set for two with a view of a forested landscape through large windows.

4. The Orchard Inn

The Orchard Inn
Saluda
  • Enjoy a couples massage or solo Swedish retreat in this peaceful bed & breakfast with gardens and a 24-hour gym.
₩398,130
₩436,943 total
includes taxes & fees
Nov 1 - Nov 2
The Orchard Inn
View all properties

Choose what matters most at spa hotels in Greenville

Pool
Hot tub
Breakfast included
4 stars
Gym

Top Greenville Hotel Reviews

Hilton Greenville

Hilton Greenville

10/10 Excellent
"Everything was exactly like I thought it would be. Hilton quality."
Joyce 2-night trip
Posted 4 hours ago
Hilton Greenville
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"All good"
Ronald 1-night trip
Posted 5 hours ago
Embassy Suites Greenville Golf Resort & Conference Center

Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your vacation. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center and a restaurant. Enjoy a massage at The Spa at Grand Bohemian. Another popular spa hotel in Greenville is Hotel Hartness.
How many spa hotels will I find in Greenville?
Among Expedia's 702 accommodation options in Greenville, there are 2 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children's Museum of the Upstate, and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Greenville Zoo and Fluor Field at the West End.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas and offer services like couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Explore a world of travel with Expedia