A riverside walkway with cyclists, a bridge, and modern buildings.

Find Resorts & Hotels with Spas in Greenville, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Resorts & Hotels with Spas

Tonight
Sep 23 - Sep 24
Tomorrow
Sep 24 - Sep 25
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Greenville hotels with a spa

A spa room with two beds, a mural, and a reception desk.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
  • Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
₩527,212
₩597,322 total
includes taxes & fees
Sep 27 - Sep 28
Grand Bohemian Lodge Greenville, Autograph Collection
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A modern interior with a large window, a chandelier, a dining area, and a hallway leading to a door.
A cozy lounge area with leather armchairs, a central table, and a fireplace.

2. Hotel Hartness

Hotel Hartness
Greenville
  • Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
₩206,253
₩278,412 total
includes taxes & fees
Sep 27 - Sep 28
Hotel Hartness
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A reception area with a wooden reception desk, a large abstract painting, and a potted plant.
A swimming pool with lounge chairs and a building with balconies.

3. Hotel Domestique

Hotel Domestique
Travelers Rest
  • Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
₩567,871
₩624,658 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Domestique
A wooden deck with chairs, surrounded by trees with autumn foliage.
A hotel with a covered front porch, steps leading up to the entrance, and snow-covered bushes.
A wooden deck with a spiral glass sculpture, potted plants, and a bench.
A dining table set for two with a view of a forested landscape through large windows.

4. The Orchard Inn

The Orchard Inn
Saluda
  • Enjoy a couples massage or solo Swedish retreat in this peaceful bed & breakfast with gardens and a 24-hour gym.
₩405,384
₩444,905 total
includes taxes & fees
Sep 27 - Sep 28
The Orchard Inn
View all properties

Choose what matters most at spa hotels in Greenville

Pool
Hot tub
Breakfast included
4 stars
Gym

Top Greenville Hotel Reviews

Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your vacation. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center and a restaurant. Enjoy a massage at The Spa at Grand Bohemian. Another popular spa hotel in Greenville is Hotel Hartness.
How many spa hotels will I find in Greenville?
Among Expedia's 705 accommodation options in Greenville, there are 2 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to Piazza Bergamo, The Peace Center, and The Children's Museum of the Upstate. If you have some spare time during your trip, you might want to check out Bon Secours Wellness Arena and Beattie House.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas and offer services like couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Explore a world of travel with Expedia