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Find Resorts & Hotels with Spas in Isle of Palms, SC

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Check availability on Isle of Palms Resorts & Hotels with Spas

Our top choices for Isle of Palms hotels with a spa

Body treatments, hot stone massages, deep-tissue massages
Wild Dunes Resort – Residences at Sweetgrass

Wild Dunes Resort – Residences at Sweetgrass

Wild Dunes Resort – Residences at Sweetgrass
3.5 star property
Isle of Palms
8.6 out of 10, Excellent, (175)
"We come here often"
United States
Joseph
The price is ₩308,841
₩415,147 total
includes taxes & fees
Dec 16 - Dec 17
Wild Dunes Resort – Residences at Sweetgrass
Couples treatment rooms, sauna, hot tub, body treatments
Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn
4.0 star property
Isle of Palms
8.8 out of 10, Excellent, (1004)
"Great Stay!"
United States
Doug
The price is ₩307,364
₩413,198 total
includes taxes & fees
Dec 16 - Dec 17
Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn
Couples treatment rooms, hot stone massages, deep-tissue massages
Harborside at Charleston Harbor Resort and Marina

Harborside at Charleston Harbor Resort and Marina

Harborside at Charleston Harbor Resort and Marina
4.0 star property
Mount Pleasant
8.6 out of 10, Excellent, (2023)
"We had a lovely room and enjoyed all the amenities at this resort on Charleston Marina. Highly recommend!"
United States
Elizabeth
Harborside at Charleston Harbor Resort and Marina
Exterior
The Beach Club at Charleston Harbor Resort and Marina

The Beach Club at Charleston Harbor Resort and Marina

The Beach Club at Charleston Harbor Resort and Marina
4.5 star property
Mount Pleasant
9.2 out of 10, Wonderful, (1005)
"Staff was courteous, hotel was beautiful."
United States
Johnna
The price is ₩171,562
₩263,993 total
includes taxes & fees
Dec 22 - Dec 23
The Beach Club at Charleston Harbor Resort and Marina
Lobby
The Francis Marion Hotel

The Francis Marion Hotel

The Francis Marion Hotel
4.0 star property
Charleston Historic District
9.0 out of 10, Wonderful, (1988)
"Nice ambiance and restaurant on site with love piano "
United States
Mila
The price is ₩190,314
₩216,958 total
includes taxes & fees
Jan 15 - Jan 16, 2026
The Francis Marion Hotel
Gift shop
Hotel Bennett

Hotel Bennett

Hotel Bennett
5.0 star property
Charleston Historic District
9.6 out of 10, Exceptional, (978)
"Great place to stay! Will definitely stay there again!"
United States
Leigh Regenold
The price is ₩589,606
₩675,520 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hotel Bennett
Couples treatment rooms, body treatments, aromatherapy
Wentworth Mansion

Wentworth Mansion

Wentworth Mansion
5.0 star property
Downtown Charleston
10.0 out of 10, Exceptional, (158)
"This was a wonderful stay. We enjoyed every minute. "
United States
Ralf
Wentworth Mansion
Deep-tissue massages, Swedish massages, prenatal massages, massages
The Restoration

The Restoration

The Restoration
4.0 star property
Charleston Historic District
9.6 out of 10, Exceptional, (1004)
"Great place to stay for a few nights while visiting!"
United States
Kelly
The price is ₩348,444
₩409,477 total
includes taxes & fees
Jan 8 - Jan 9, 2026
The Restoration
Couples treatment rooms, body treatments, hot stone massages
The Dewberry Charleston

The Dewberry Charleston

The Dewberry Charleston
5.0 star property
Charleston Historic District
9.6 out of 10, Exceptional, (1000)
"Great stay, terrific room, superb location. Staff was efficient and very pleasant."
United States
William
The price is ₩545,275
₩624,984 total
includes taxes & fees
Jan 11 - Jan 12, 2026
The Dewberry Charleston
Couples treatment rooms, sauna, body treatments, hydrotherapy
The Charleston Place

The Charleston Place

The Charleston Place
5.0 star property
Charleston Historic District
9.6 out of 10, Exceptional, (1004)
"Staff was great, room perfect and we had a lovely time in Charleston!😊"
United States
Janis
The Charleston Place
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Isle of Palms Hotel Reviews

Frequently asked questions

Looking to vacation at a spa hotel in Isle of Palms?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers love the beaches in Isle of Palms. Enjoy the live music and many popular restaurants during your vacation. Spa hotels are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Isle of Palms?
Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn is a top beach spa hotel featuring 5 pools, 8 restaurants, 9 bars, and a golf course. Enjoy a facial, body scrub, or detox wrap at The Spa at Sweetgrass. Another popular spa hotel in Isle of Palms is Wild Dunes Resort – Residences at Sweetgrass.
How many spa hotels will I find in Isle of Palms?
Among Expedia's 1813 accommodation options in Isle of Palms, there are 2 spa hotels.
What's there to see and do in Isle of Palms?
Enjoy all that Isle of Palms has to offer and visit Isle of Palms Beach, Isle of Palms Marina, and Front Beach. If you have some spare time during your trip, you might want to check out Wild Dunes Resort Golf Course and Dewees Island Beach.
What is a Isle of Palms spa hotel?
Spa hotels in Isle of Palms provide lodging and have a full on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.