The Best Hotels Closest to Main Street Hyannis in Hyannis for 2026

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Our top choices for Main Street Hyannis hotels

A man sitting at a table with a laptop, overlooking a pool area with chairs and tables.

1. Hyannis Travel Inn

0.2 km from Main Street Hyannis

Colleen

₩151,091 total

includes taxes & fees

Nov 15 - Nov 16

A row of wicker chairs with cushions, a map on the wall, and a view of the outside through a window.

2. Anchor In Distinctive Waterfront Lodging

0.6 km from Main Street Hyannis

Anita

₩242,822 total

includes taxes & fees

Nov 23 - Nov 24

A restaurant with outdoor seating, string lights, and a decorative wall.

3. Uncommoner Hotel by Reverie Boutique Collection

1.9 km from Main Street Hyannis

Jen

₩164,198 total

includes taxes & fees

Dec 1 - Dec 2

A pool area with lounge chairs and flags.

4. The Cove at Yarmouth by Westgate Resorts

2.1 km from Main Street Hyannis

Manizheh

₩139,330 total

includes taxes & fees

Nov 16 - Nov 17

A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.

5. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

0.3 km from Main Street Hyannis

Holly

₩167,353 total

includes taxes & fees

Dec 6 - Dec 7

A modern conference room with a long table, chairs, a flat-screen TV, and pendant lighting.

6. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

2.3 km from Main Street Hyannis

Estefany

₩193,298 total

includes taxes & fees

Nov 20 - Nov 21

An indoor swimming pool with a wooden ceiling, potted plants, and lounge chairs.

7. Bayside Resort Hotel

2.3 km from Main Street Hyannis

Michela

₩149,567 total

includes taxes & fees

Nov 15 - Nov 16

An indoor swimming pool with a high ceiling and large windows.

8. Courtyard By Marriott Cape Cod Hyannis

1.7 km from Main Street Hyannis

ELIZABETH

₩207,813 total

includes taxes & fees

Nov 23 - Nov 24

An outdoor patio with wicker furniture, a fire pit, and umbrellas.

9. Hampton Inn & Suites Cape Cod-West Yarmouth

1.7 km from Main Street Hyannis

Paul

₩154,758 total

includes taxes & fees

Dec 13 - Dec 14

An indoor swimming pool with a brick wall, a white table with chairs, and a large window.

10. Courtyard Resort

0.3 km from Main Street Hyannis

chris

₩213,673 total

includes taxes & fees

Nov 25 - Nov 26

An outdoor patio with round tables and chairs, a fire pit, and a covered seating area with string lights.

11. Doubletree by Hilton Cape Cod - Hyannis

0.9 km from Main Street Hyannis

Tammie

₩193,773 total

includes taxes & fees

Nov 21 - Nov 22

A long dining table with chairs, a kitchen area, and a large window.

12. Comfort Inn Hyannis - Cape Cod

0.3 km from Main Street Hyannis

Paul

₩141,406 total

includes taxes & fees

Dec 6 - Dec 7

A spacious, modern interior with a high ceiling, a seating area with sofas, a desk with a computer, and a large TV screen.

13. Holiday Inn Hyannis by IHG

2.9 km from Main Street Hyannis

Alexander

₩160,649 total

includes taxes & fees

Dec 11 - Dec 12

An outdoor seating area with wicker furniture, umbrellas, and a stone wall.

14. Hyannis Harbor Hotel

0.6 km from Main Street Hyannis

Gary

₩229,764 total

includes taxes & fees

Nov 15 - Nov 16

A house with a white door, a mailbox, and a sign reading '270 Ocean Ave.'

15. Sea Breeze Inn

1.8 km from Main Street Hyannis

Ann

₩120,566 total

includes taxes & fees

Nov 15 - Nov 16

A spacious living area with a checkered floor, a wooden staircase, a sofa set, a television, and a potted plant.

16. Hyannis Plaza Hotel

0.9 km from Main Street Hyannis

KARL

₩158,605 total

includes taxes & fees

Nov 23 - Nov 24

A hotel room with two beige sofas, a glass coffee table, and a flat-screen TV mounted on the wall.

17. Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area

1.5 km from Main Street Hyannis

Fabricio

₩105,570 total

includes taxes & fees

Nov 15 - Nov 16

An indoor swimming pool with clear glass walls, a metal roof, and several Adirondack chairs around the pool.

18. Econo Lodge West Yarmouth on Cape Cod

1.5 km from Main Street Hyannis

Denise

₩114,454 total

includes taxes & fees

Nov 15 - Nov 16

A beach with sand, flowers, and a clear sky.

19. Sal's Place

2.5 km from Main Street Hyannis

₩541,595 total

includes taxes & fees

Nov 15 - Nov 16

A white building with a sign reading "The Village Inn" indicating it is a fine lodging and breakfast establishment.

20. The Village Inn Cape Cod

6.1 km from Main Street Hyannis

Patti

₩343,416 total

includes taxes & fees

Nov 29 - Nov 30

View all properties

Compare popular hotels close to Main Street Hyannis

Property	Property class	Guest rating
Hyannis Travel Inn	2.5 star property	9.6 Exceptional 1,039 reviews	View
Anchor In Distinctive Waterfront Lodging	3.0 star property	9.4 Exceptional 1,000 reviews	View
Uncommoner Hotel by Reverie Boutique Collection	4.0 star property	9.2 Wonderful 423 reviews	View
The Cove at Yarmouth by Westgate Resorts	3.0 star property	9.2 Wonderful 275 reviews	View
Heritage House Inn on Cape Cod, an Ascend Collection Hotel	2.5 star property	9.0 Wonderful 204 reviews	View

Other attractions near Main Street Hyannis

A bronze statue of a man in a polo shirt standing in front of a building with a brick facade, white columns, and an American flag.

John F. Kennedy Hyannis Museum

8.8/10 (444 reviews)

Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.

See properties

Top Main Street Hyannis Hotel Reviews

Hyannis Travel Inn

Hyannis

10/10 Excellent

The location is everything as it is 1 street over from main street. The room was a nice size with 2 double beds and was clean with a large private balcony overlooking the street. The room had a mini fridge, a TV with limited cable, a telephone, great air conditioning and lighting. The bathroom was small with a very small and low toilet, low water pressure and a very small shower head, but the water temperature was good. Also limited counter space. The beds were very uncomfortable , uneven And...

Luis

The Village Inn Cape Cod

Yarmouth Port

10/10 Excellent

Anonymous traveler

A kitchen counter with a knife and a cutting board, a sign with a flower, and a view of a dining area through glass doors.

Sea Street Inn

Hyannis

10/10 Excellent

Gerry

Anchor In Distinctive Waterfront Lodging

Hyannis

10/10 Excellent

Karen

A porch with white chairs and a planter with flowers.

The Captain Farris House B&B

Bass River

10/10 Excellent

Couldn't ask for more. The staff were extremely friendly and generous. The room was beautiful -- not overly luxurious, but full of character and with an extremely comfortable bed. One fixture on the bathroom sink was broken, and the TV was on the small side, but I would hardly call these complaints given how nice the overall experience was. And to top it off, the breakfast was amazing -- both the quality of the food and the service. We would definitely stay at the Captain Farris again.

Matt

Blue Lobster Inn

Bass River

10/10 Excellent

Crystal

A swimming pool with a fountain, surrounded by greenery and a gazebo.

Brewster by the Sea Inn

West Brewster

10/10 Excellent

Tony and Rachel

A two-story house with a symmetrical facade, a central entrance, and a flag.

Candleberry Inn on Cape Cod

Brewster

10/10 Excellent

Great place to stay! My husband and I were a little worried about vacationing during the pandemic. But, we were put at ease when we read about the policies the innkeepers (Marco and Angelo) put in place during COVID-19, and the overall cleanliness of the inn and our room. The gourmet breakfast and afternoon treats were delicious! It's one of the things we look forward each day. The amenities were great! Since a lot of the restaurants are already fully booked, we're fortunate to have our own...

Maria&Mike

Uncommoner Hotel by Reverie Boutique Collection

West Yarmouth

10/10 Excellent

Michael

The Cove at Yarmouth by Westgate Resorts

West Yarmouth

10/10 Excellent

Anonymous traveler

A hotel with a white facade, a covered outdoor seating area with white chairs and tables, and a view of the sunset.

The Escape Inn

Bass River

10/10 Excellent

Steven

A pathway flanked by vibrant flowers and greenery, leading to a house with large windows.

The Villa Callo Inn

West Harwich

10/10 Excellent

Shawn

A flagpole with an American flag, a circular flower bed with pink and white flowers, and white Adirondack chairs.

A Beach Breeze Inn

West Harwich

10/10 Excellent

Lois

A deck with outdoor furniture, a white railing, and a view of a forested landscape.

The Ocean View

Centerville

10/10 Excellent

Great location. Just steps away from Craigville. Rooms are clean and quaint. We loved hanging out on our private patio. We got a partial ocean view room, which basically means downstairs room. Next time we stay we are going to pay the extra money for a ocean view room , which is an upstairs room with a balcony and they must have really great views. The staff was pleasant and accommodating. They gave us a tour of their regatta suite and we would really love to stay there for our anniversary....

Anonymous traveler

A beach view from a balcony with a railing, beach chairs, umbrellas, and a small gazebo.

Ocean Club on Smuggler's Beach

Bass River

10/10 Excellent

Darlene

Hampton Inn & Suites Cape Cod-West Yarmouth

West Yarmouth

10/10 Excellent

Marta

Bayside Resort Hotel

West Yarmouth

10/10 Excellent

Abigail

Frequently Asked Questions

What's the area like around Main Street Hyannis?

Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, check out the 197 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Main Street Hyannis?

Adjacent to Main Street Hyannis, Hyannis Travel Inn is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. Other good options within a short distance include Hyannis Harbor Hotel and Hyannis Plaza Hotel.

How many hotels can I expect to find close to Main Street Hyannis?

Expedia has 197 hotels and other accommodations within a mile from Main Street Hyannis.

If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view top deals close to Main Street Hyannis.

Where can I learn more about changing or cancelling my trip in the area near Main Street Hyannis?

For more information about updating your stay near Main Street Hyannis or cancelling it, click here.

What can I see and do near Main Street Hyannis?

John F. Kennedy Hyannis Museum, Centerville Historical Museum, and Edward Gorey House feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse, and West Parish Meetinghouse are landmarks that you won't want to miss. Local parks like Lewis Bay, Veterans Memorial Park, and Dennis Pond Conservation Area are peaceful spots to stop and take in some fresh air.

Find hotels near Main Street Hyannis, Hyannis from ₩114,685

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Property class

Guest rating

Our top choices for Main Street Hyannis hotels

1. Hyannis Travel Inn

2. Anchor In Distinctive Waterfront Lodging

3. Uncommoner Hotel by Reverie Boutique Collection

4. The Cove at Yarmouth by Westgate Resorts

5. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

6. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

7. Bayside Resort Hotel

8. Courtyard By Marriott Cape Cod Hyannis

9. Hampton Inn & Suites Cape Cod-West Yarmouth

10. Courtyard Resort

11. Doubletree by Hilton Cape Cod - Hyannis

12. Comfort Inn Hyannis - Cape Cod

13. Holiday Inn Hyannis by IHG

14. Hyannis Harbor Hotel

15. Sea Breeze Inn

16. Hyannis Plaza Hotel

17. Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area

18. Econo Lodge West Yarmouth on Cape Cod

19. Sal's Place

20. The Village Inn Cape Cod

Compare popular hotels close to Main Street Hyannis

Other attractions near Main Street Hyannis

John F. Kennedy Hyannis Museum

Top Main Street Hyannis Hotel Reviews

Hyannis Travel Inn

10/10 Excellent

Frequently Asked Questions

What's the area like around Main Street Hyannis?

What's the best hotel to stay near Main Street Hyannis?

How many hotels can I expect to find close to Main Street Hyannis?

If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?

Where can I learn more about changing or cancelling my trip in the area near Main Street Hyannis?

What can I see and do near Main Street Hyannis?