Find hotels near Main Street Hyannis, Hyannis from ₩126,133

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Dec 21 - Dec 22
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Dec 22 - Dec 23
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Dec 26 - Dec 28
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Our top choices for Main Street Hyannis hotels

Terrace/patio
Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
3.0 star property
0.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (1001)
"Staff member Sandy very congenial when we checked in. Laid back atmosphere (early December). Will consider for future Hyannis stay."
United States
Lawrence
The price is ₩206,110
₩278,163 total
includes taxes & fees
Dec 22 - Dec 23
Anchor In Distinctive Waterfront Lodging
Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers
Bayside Resort Hotel

Bayside Resort Hotel

Bayside Resort Hotel
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (1523)
"Reception staff was warm and welcoming! "
United States
Liza
Bayside Resort Hotel
Indoor pool, seasonal outdoor pool
The Cove at Yarmouth by Westgate Resorts

The Cove at Yarmouth by Westgate Resorts

The Cove at Yarmouth by Westgate Resorts
3.0 star property
2.1 km from Main Street Hyannis
9.2 out of 10, Wonderful, (243)
"Great place to stay. Clean, friendly and accommodating!"
United States
Mike
The price is ₩161,166
₩184,455 total
includes taxes & fees
Dec 22 - Dec 23
The Cove at Yarmouth by Westgate Resorts
Lobby
Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.5 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (661)
"Excellent staff-clean rooms-great location"
United States
Patrice
The price is ₩162,007
₩185,417 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers
Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
2.5 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (1002)
"Rooms were spotless, staff was wonderful and very accommodating. Amenities were great… coffee, tea and hot chocolate in lobby 24 hours a day. Lobby was decorated for Christmas and the holiday season… made for a very festive stay. Breakfast was awesome too!!!"
United States
Deborah
The price is ₩167,991
₩192,266 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Hampton Inn & Suites Cape Cod-West Yarmouth
Indoor pool
Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
3.0 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (487)
"Pretty nice location"
United States
Saulius
The price is ₩180,786
₩206,908 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Courtyard By Marriott Cape Cod Hyannis
Exterior
Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
4.0 star property
1 km from Main Street Hyannis
8.4 out of 10, Very Good, (878)
"Nice room, freindly staff. The downside is the food was pricey. "
United States
Steffanie
The price is ₩169,616
₩194,126 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Doubletree by Hilton Cape Cod - Hyannis
Indoor pool
Courtyard Resort

Courtyard Resort

Courtyard Resort
2.0 star property
0.3 km from Main Street Hyannis
8.2 out of 10, Very Good, (46)
"Clean and inexpensive"
United States
Robert
The price is ₩161,046
₩184,318 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard Resort
Free daily continental breakfast
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
2.5 star property
0.3 km from Main Street Hyannis
8.0 out of 10, Very Good, (1005)
"Nice hotel had a perfect stay"
United States
David
The price is ₩144,942
₩165,887 total
includes taxes & fees
Dec 27 - Dec 28
Comfort Inn Hyannis - Cape Cod
Front of property
Hyannis Harbor Hotel

Hyannis Harbor Hotel

Hyannis Harbor Hotel
3.5 star property
0.6 km from Main Street Hyannis
8.0 out of 10, Very Good, (1000)
"Amazing place "
United States
Mounir
The price is ₩184,612
₩270,948 total
includes taxes & fees
Dec 22 - Dec 23
Hyannis Harbor Hotel
Exterior
Cape Sands Inn

Cape Sands Inn

Cape Sands Inn
2.5 star property
1.9 km from Main Street Hyannis
8.2 out of 10, Very Good, (1016)
"Clean room courteous staff and easy check in "
United States
Linda
The price is ₩110,206
₩126,133 total
includes taxes & fees
Dec 22 - Dec 23
Cape Sands Inn
Exterior
Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG
3.0 star property
2.9 km from Main Street Hyannis
8.2 out of 10, Very Good, (977)
"Check in was easy and the front desk person was wonderful. "
United States
Anastasios
The price is ₩141,839
₩162,335 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Hyannis by IHG
Lobby
Hyannis Plaza Hotel

Hyannis Plaza Hotel

Hyannis Plaza Hotel
2.5 star property
0.9 km from Main Street Hyannis
7.0 out of 10, Good, (972)
"good stay for night"
United States
David
The price is ₩107,546
₩137,862 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Hyannis Plaza Hotel
Family House, Private Bathroom, Pool View | Lounge
Sal's Place

Sal's Place

Sal's Place
2.0 star property
2.5 km from Main Street Hyannis
The price is ₩413,697
₩650,775 total
includes taxes & fees
Dec 29 - Dec 30
Sal's Place
Front of property
The Village Inn Cape Cod

The Village Inn Cape Cod

The Village Inn Cape Cod
3.5 star property
6.1 km from Main Street Hyannis
10.0 out of 10, Exceptional, (223)
"It was so charming, would definitely stay there again! "
United States
Kyle
The price is ₩249,696
₩285,776 total
includes taxes & fees
Dec 27 - Dec 28
The Village Inn Cape Cod
Outdoor pool, pool umbrellas, sun loungers
Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod
4.0 star property
3.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (417)
"The entire place was spotless and rooom beet pleasant. Staff was super friendly and the Landshark Bar was excellent. Highly recommend a stay here ! "
United States
Stephen
The price is ₩206,849
₩321,296 total
includes taxes & fees
Dec 22 - Dec 23
Margaritaville Resort Cape Cod
Property grounds
The Escape Inn

The Escape Inn

The Escape Inn
2.5 star property
7.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (656)
"clean, convenient and very easy check in/out. "
United States
chris
The price is ₩118,672
₩135,826 total
includes taxes & fees
Dec 22 - Dec 23
The Escape Inn
Exterior
Aiden by Best Western Cape Cod - West Yarmouth

Aiden by Best Western Cape Cod - West Yarmouth

Aiden by Best Western Cape Cod - West Yarmouth
3.0 star property
3.7 km from Main Street Hyannis
8.0 out of 10, Very Good, (1002)
"Nice room and nice staff"
United States
Jessica
The price is ₩119,307
₩136,548 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Aiden by Best Western Cape Cod - West Yarmouth
Gazebo
Veranda Cape Cod Family Resort

Veranda Cape Cod Family Resort

Veranda Cape Cod Family Resort
2.5 star property
7.8 km from Main Street Hyannis
9.2 out of 10, Wonderful, (262)
"Beautiful grounds, quiet and comfortable. Very well run. "
United States
Benita
The price is ₩264,471
₩302,679 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Veranda Cape Cod Family Resort
Indoor pool, open 8:00 AM to 10:00 PM, sun loungers
The Mariner Resort Cape Cod by The Red Collection

The Mariner Resort Cape Cod by The Red Collection

The Mariner Resort Cape Cod by The Red Collection
3.0 star property
4.3 km from Main Street Hyannis
8.0 out of 10, Very Good, (436)
"Safe parking, breakfast selection could be better, amazing service, nice area"
United States
Ryan
The price is ₩109,225
₩139,784 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Mariner Resort Cape Cod by The Red Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Main Street Hyannis Hotel Reviews

Courtyard Resort

Courtyard Resort

10/10 Excellent
"Clean rooms, full kitchens, good area. "
Michael 1-night trip
Posted 4 days ago
Courtyard Resort

Hotels near other Main Street Hyannis attractions

John F. Kennedy Hyannis Museum showcases bronze statue and historic architecture in Hyannis Massachusetts

John F. Kennedy Hyannis Museum

4.4/5 (259 reviews)
Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.
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Cape Cod Maritime Museum which includes a bay or harbor and signage

Cape Cod Maritime Museum

You can spend an afternoon exploring the galleries in Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the beautiful beaches in this family-friendly area, or check out its seafood restaurants.
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Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, check out the 182 hotels and other accommodations you'll find within a mile.
What's the best hotel to stay near Main Street Hyannis?
Adjacent to Main Street Hyannis, Courtyard Resort is one of the top choices for your stay based on our traveler data, and this hotel offers an indoor pool and free parking. Other good options within a short distance include Hyannis Travel Inn and Comfort Inn Hyannis - Cape Cod.
How many hotels can I expect to find close to Main Street Hyannis?
Expedia has 182 hotels and other accommodations within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view top deals close to Main Street Hyannis.
Where can I learn more about changing or cancelling my trip in the area near Main Street Hyannis?
For more information about updating your stay near Main Street Hyannis or cancelling it, click here.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Cape Cod Maritime Museum, and Whydah Pirate Museum feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse, and West Parish Meetinghouse are landmarks that you won't want to miss. You can enjoy live performances at Cape Cod Melody Tent and Barnstable Performing Arts Center.