Find hotels in Matlacha Isles, Cape Coral

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Matlacha Isles hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
23.2 km from Matlacha Isles
9.0 out of 10, Wonderful, (1,389 reviews)
"Best place to stay!"
United States
Cory
The price is ₩263,533
₩326,678 total
includes taxes & fees
Apr 27 - Apr 28
Lani Kai Beachfront Resort

MainStay Suites Fort Myers East I-75

MainStay Suites Fort Myers East I-75
2.5 star property
24.7 km from Matlacha Isles
9.6 out of 10, Exceptional, (345 reviews)
"Clean room great breakfast helpful staff"
United States
JoEllen
The price is ₩118,884
₩132,555 total
includes taxes & fees
May 14 - May 15
MainStay Suites Fort Myers East I-75

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
23.1 km from Matlacha Isles
7.6 out of 10, Good, (382 reviews)
"Great and clean hotel friendly and family oriented! "
United States
Noel
The price is ₩157,678
₩241,474 total
includes taxes & fees
Apr 21 - Apr 22
The Bay Inn at Lani Kai

Comfort Suites Fort Myers East I-75

Comfort Suites Fort Myers East I-75
2.5 star property
24.8 km from Matlacha Isles
9.6 out of 10, Exceptional, (441 reviews)
"Incredibly clean room would definitely stay again!"
Canada
Christopher
The price is ₩134,593
₩150,070 total
includes taxes & fees
May 10 - May 11
Comfort Suites Fort Myers East I-75

Park Motel

Park Motel
2.5 star property
Diplomat, 17.2 km from Matlacha Isles
9.2 out of 10, Wonderful, (45 reviews)
"Clean, quiet, very friendly and helpful staff, hot tub in room very relaxing."
United States
Kristeen
The price is ₩139,127
₩155,126 total
includes taxes & fees
Apr 17 - Apr 18
Park Motel

Extended Stay America Premier Suites - Fort Myers - Airport

Extended Stay America Premier Suites - Fort Myers - Airport
2.5 star property
23.6 km from Matlacha Isles
8.8 out of 10, Excellent, (941 reviews)
"Great stay"
United States
Cliff
The price is ₩100,687
₩112,259 total
includes taxes & fees
Apr 19 - Apr 20
Extended Stay America Premier Suites - Fort Myers - Airport

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
28.6 km from Matlacha Isles
9.2 out of 10, Wonderful, (1,011 reviews)
"Beautiful beach view, friendly staff and lots of beach space for our family to enjoy!"
United States
Daniel
The price is ₩238,283
₩743,822 total
includes taxes & fees
May 9 - May 10
Pointe Estero Beach Resort

1 Island Hideaway

1 Island Hideaway
3.0 star property
25.1 km from Matlacha Isles
8.6 out of 10, Excellent, (32 reviews)
"Clean and modern apartment and we stayed on first floor. Walking distance to beach with hot tub and pool. Not really walking distance to bars/restaurants so probably best to have a car. Worth the price."
United States
Howard
The price is ₩292,978
₩653,355 total
includes taxes & fees
May 12 - May 13
1 Island Hideaway

Comfort Inn Fort Myers Northeast

Comfort Inn Fort Myers Northeast
2.5 star property
25.8 km from Matlacha Isles
7.8 out of 10, Good, (717 reviews)
"Friendly staff!"
United States
Tom
The price is ₩106,370
₩118,603 total
includes taxes & fees
Apr 26 - Apr 27
Comfort Inn Fort Myers Northeast

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
20.3 km from Matlacha Isles
8.6 out of 10, Excellent, (991 reviews)
"Such a cute little stay. We enjoyed our time there. I definitely recommend and will come back next year! "
United States
Monica
The price is ₩151,825
₩169,285 total
includes taxes & fees
Apr 16 - Apr 17
Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
20.4 km from Matlacha Isles
8.8 out of 10, Excellent, (1,000 reviews)
"Lovely sunset views, fire pit table by the docks, hammocks"
United States
Debbie
The price is ₩139,052
₩155,044 total
includes taxes & fees
Apr 21 - Apr 22
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

StudioRes by Marriott Fort Myers Airport

StudioRes by Marriott Fort Myers Airport
3.0 star property
29.5 km from Matlacha Isles
9.4 out of 10, Exceptional, (46 reviews)
"Loved stay here!!! "
United States
Melissa
The price is ₩130,147
₩145,114 total
includes taxes & fees
Apr 26 - Apr 27
StudioRes by Marriott Fort Myers Airport

Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG
2.5 star property
29 km from Matlacha Isles
9.6 out of 10, Exceptional, (1,028 reviews)
"Excellent stay, clean, friendly staff. Would stay again"
United States
Terri
The price is ₩145,414
₩162,139 total
includes taxes & fees
Apr 26 - Apr 27
Holiday Inn Express & Suites Fort Myers Airport by IHG

Boca Grande Hotel

Boca Grande Hotel
2.5 star property
28.8 km from Matlacha Isles
8.8 out of 10, Excellent, (623 reviews)
"Always love staying here. Great staff"
United States
Dave
The price is ₩213,476
₩239,093 total
includes taxes & fees
Apr 19 - Apr 20
Boca Grande Hotel

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
21.7 km from Matlacha Isles
9.4 out of 10, Exceptional, (1,320 reviews)
"Very nice place to stay. Really clean and great views "
United States
Adam
The price is ₩348,482
₩485,416 total
includes taxes & fees
May 13 - May 14
Pink Shell Beach Resort and Marina

The Anchor Inn

The Anchor Inn
2.0 star property
21.8 km from Matlacha Isles
10.0 out of 10, Exceptional, (22 reviews)
"The property was beautiful, everything was in perfect condition, would definitely go back!!"
United States
Jennifer
The price is ₩337,027
₩397,869 total
includes taxes & fees
Apr 26 - Apr 27
The Anchor Inn

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
2.0 star property
28 km from Matlacha Isles
8.0 out of 10, Very Good, (1,665 reviews)
"Great location, breakfast was mostly sweets."
United States
Iliana
The price is ₩111,302
₩124,101 total
includes taxes & fees
Apr 16 - Apr 17
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Americas Best Value Inn Ft. Myers

Americas Best Value Inn Ft. Myers
3.0 star property
19.3 km from Matlacha Isles
7.6 out of 10, Good, (1,227 reviews)
"Great staff loved the quick breakfast!"
United States
Emil Peter Busko
The price is ₩112,082
₩124,971 total
includes taxes & fees
Apr 20 - Apr 21
Americas Best Value Inn Ft. Myers

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
22.7 km from Matlacha Isles
9.2 out of 10, Wonderful, (1,778 reviews)
"Central location, lovely accommodation and great food "
United States
Keren
The price is ₩396,035
₩478,385 total
includes taxes & fees
May 3 - May 4
Sanibel Island Beach Resort

TownePlace Suites by Marriott Fort Myers Gulf Coast

TownePlace Suites by Marriott Fort Myers Gulf Coast
3.0 star property
29.9 km from Matlacha Isles
9.2 out of 10, Wonderful, (180 reviews)
"Great size room and the front desk staff was Great!"
United States
Karen
The price is ₩151,642
₩169,081 total
includes taxes & fees
May 15 - May 16
TownePlace Suites by Marriott Fort Myers Gulf Coast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Matlacha Isles

Find the best Matlacha Isles areas and neighborhoods for the activities you enjoy most.

Pelican

If you're spending some time in Pelican, Tarpon Point and Chabad Jewish Center are top sights worth seeing.

Caloosahatchee

If you're spending some time in Caloosahatchee, Cape Coral Yacht Club Beach and Dolphin Marina are top sights worth seeing.

Hancock

While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Sun Splash Water Park.

Yacht Club

While there might not be top attractions in Yacht Club, you can explore the larger area and discover places like Cape Coral Yacht Club Beach and Dolphin Marina.

Burnt Store

Though Burnt Store might not have many top sights, you can venture to the surrounding area to see attractions like Coral Oaks Golf Course and Burnt Store Marina.

Top Matlacha Isles Hotel Reviews

Frequently asked questions

What is Matlacha Isles like?
Travelers will be sure to find plenty to entertain them in Cape Coral's Matlacha Isles neighborhood.
How many hotels will I be able to find in the Matlacha Isles area?
When you want to kick up your feet after a day of exploring the sights in Cape Coral, you can choose from 18 Expedia hotels and other accommodations in Matlacha Isles.
If I need to cancel my hotel reservation in Matlacha Isles, will I receive a refund?
Yes, you'll find most hotel room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best deals available in Matlacha Isles.
Where can I learn more about changing or cancelling my trip to Matlacha Isles?
To find more details about changing or cancelling your trip to Matlacha Isles, go to https://www.expedia.com/service/.
What are the top things to see and do in Matlacha Isles?
A few places to visit in the area around Matlacha Isles include Griffen American Center for Haitian Art, Lovegrove Gallery & Gardens, and Royal Tee Golf Club. While you're out sightseeing in Cape Coral, be sure to visit other sights like Little Dead Key or Big Dead Key.