New Madrid County Vacations & Trips

Book a Hotel + Flight or Car together to unlock savings

Photo by Ryan Coleman

  • Plan, book, travel with confidence

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    Better together

    Save up to ₩234,741 when you book a flight and hotel together*
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    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Rest easy

    Plan, book, and manage your trip all in one place

New Madrid County Hotel Deals

Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is ₩142,273 per night from Oct 12 to Oct 13
₩142,273
₩161,088 total
Oct 12 - Oct 13
includes taxes & fees
8.8/10 Excellent! (401 reviews)
"Everything was enjoyable and the staff was top notch."

Reviewed on Sep 30, 2025

Hampton Inn Sikeston
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61, Portageville, MO
Fully refundableReserve now, pay when you stay
The price is ₩79,751 per night from Oct 12 to Oct 13
₩79,751
₩86,109 total
Oct 12 - Oct 13
includes taxes & fees
8/10 Very Good! (701 reviews)
"The staff was wonderful"

Reviewed on Sep 30, 2025

New Orleans Inn Portageville
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 out of 5
1239 Commerce Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is ₩142,062 per night from Oct 12 to Oct 13
₩142,062
₩160,850 total
Oct 12 - Oct 13
includes taxes & fees
9.4/10 Exceptional! (25 reviews)
"The stars tell it all😉"

Reviewed on Sep 22, 2025

Fairfield Inn & Suites by Marriott Sikeston
See all 94 properties in New Madrid County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a New Madrid County vacation package cost?
Customize your New Madrid County package from a low . Choose from any combination of hotels, flights and rental cars to pull together the getaway you've long been dreaming about. Remember to add on a few experiences or activities!
How do I get a cheap travel package to New Madrid County?
Bundling your hotel and flight with Expedia won't just save you time — it'll save you a pretty penny too. A New Madrid County vacation package makes it easy to put together your dream adventure. With more than 550 airlines across the world to choose from, finding convenient flights that fit your schedule won't be a hassle. Not only that, we've got over 1,000,000 properties globally to pick from. Now that's what we call choice. No matter who you are, Expedia puts more of the world within your reach.
What are the top hotels in New Madrid County?
Portageville is one place that most visitors to New Madrid County include in their itinerary. For a memorable stay here, check out Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel.
How far in advance should I book my New Madrid County vacation?
To bag cheap prices, book nice and early. Air carriers usually advertise flights, along with some of the lowest fares, up to 12 months prior to departure. Hotels, activities and car rental should also be booked early so you can have the pick of the bunch. If you've decided on a last-minute getaway in New Madrid County, there are always plenty of great bargains to be had on Expedia. Book your escape today!
What does an Expedia New Madrid County travel package include?
Packages include hotels, rental cars and flights, but you can combine any of them to create your dream New Madrid County escape. You can also add on fun stuff like activities and tours once you've made your booking. You're in charge! When you bundle your bookings with Expedia, you'll score discounts you won't find elsewhere.
What should I know before booking a New Madrid County travel package?
You'll score great savings when you bundle your hotels, flights and rental cars into a package. Plus, booking everything in one spot makes trip planning easier. So why waste time or money? Whether you're organizing a luxury romantic escape or a budget solo adventure, take a look at our vacation packages today.
Can I choose my airline with a New Madrid County Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines around the world. Our vacation packages give you the flexibility to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my New Madrid County vacation package?
You sure can, and we're here to help. You may be able to change or cancel your New Madrid County vacation package for free within 24 hours of booking. But you may be charged a fee by your airline, hotel or car rental company for older bookings. If your circumstances suddenly change, visit our Customer Service Portal for further information.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.