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Our top choices for Rochester hotels

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic Scleanliness Convenient hotel near Mayo Clinic with free Wi-Fi, parking, and daily breakfast.

Spark by Hilton Rochester South
Spark by Hilton Rochester Southcleanliness Unwind in this modern Rochester hotel close to Mayo Clinic for medical visits.

Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHGcleanliness Enjoy a stay near Mayo Clinic with a refreshing hot tub and free breakfast.

Econo Lodge Mayo Clinic Area
Econo Lodge Mayo Clinic Areacleanliness Peaceful stay just 5 minutes from Mayo Clinic with free breakfast and parking.

Hampton Inn Rochester-South
Hampton Inn Rochester-Southcleanliness Peaceful haven 5 minutes from Mayo Clinic, with complimentary breakfast daily.

AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Cliniccleanliness Quiet retreat near Mayo Clinic with convenient dining and wellness amenities.

Cobblestone Hotel & Suites - Austin
Cobblestone Hotel & Suites - Austincleanliness Enjoy your stay in Austin with easy access to the park and indoor swimming.

Comfort Inn & Suites West - Medical Center
Comfort Inn & Suites West - Medical Centercleanliness Just a short drive from Mayo Clinic, with an indoor pool for year-round comfort.

Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Areacleanliness Relax close to Mayo Clinic with indoor pools and convenient dining options.

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary'scleanliness Convenient hotel near Mayo Clinic with pool, restaurant, and complimentary perks.

Comfort Inn & Suites Rochester South Mayo Clinic
Comfort Inn & Suites Rochester South Mayo Cliniccleanliness Experience comfort near Rochester International Airport with a complimentary shuttle.

Country Inn & Suites Rochester South Mayo Clinic
Country Inn & Suites Rochester South Mayo Cliniccleanliness Contemporary hotel near Mayo Clinic offers comfort with indoor pool and hot tub.

Days Inn by Wyndham Austin
Days Inn by Wyndham Austincleanliness Economical Austin stay with free breakfast, parking, and WiFi for business trips.

Sleep Inn & Suites West-Near Medical Center
Sleep Inn & Suites West-Near Medical Centercleanliness Convenient access to Mayo Clinic, with indoor pool and free breakfast for travelers.

Hampton Inn & Suites Rochester-North
Hampton Inn & Suites Rochester-Northcleanliness Explore Mayo Clinic then unwind in this modern Rochester hotel's heated pool.

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Areacleanliness Enjoy a peaceful retreat near Mayo Clinic with complimentary shuttle service.

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Microtel Inn & Suites by Wyndham Rochester North Mayo Cliniccleanliness Enjoy tranquility near Mayo Clinic with free breakfast and parking.

Aspen Select
Aspen Selectcleanliness Enjoy easy access to Mayo Clinic and fuel your stay with free breakfast.

Stone Mill Hotel & Suites
Stone Mill Hotel & Suitescleanliness Unwind at this charming hotel next to a scenic golf course in Lanesboro.

Residence Inn by Marriott Rochester Mayo Clinic Area South
Residence Inn by Marriott Rochester Mayo Clinic Area Southcleanliness Relax near Mayo Clinic with a hot tub and modern fitness center at your disposal.
Where to stay in Rochester

Downtown Rochester
Downtown Rochester pulses around Mayo Clinic's towering medical complex, where glass-walled hospitals create a modern healthcare cityscape. The Plummer Building's distinctive clock tower anchors the district. Medical shuttles weave between facilities as patients navigate tree-lined streets. Peace Plaza offers respite with fountains and sculptures. This medical hub features excellent walkability with the Mayo shuttle system connecting facilities every 10-15 minutes. Silver Lake Park nearby provides scenic walking paths. Downtown dining emphasizes quick, healthy options with extended hours. Most accommodations offer patient amenities and clinic shuttles.

Kutzky Park
Kutzky Park is a charming residential haven in Rochester with tree-lined streets and early 20th-century homes. Its namesake park offers walking paths, playgrounds, and green lawns perfect for picnics. History and architecture fans will appreciate the well-preserved Craftsman and Colonial Revival homes. The quiet neighborhood provides a peaceful retreat from city life. Tennis enthusiasts can visit Kutzky Park Tennis Center for a match. While dining options are limited within the area, downtown Rochester's attractions are just a short drive away.

Historic Southwest
Historic Southwest showcases Rochester's architectural heritage with grand early 1900s homes built by Mayo Clinic physicians. Colonial Revival, Tudor, and Prairie style mansions line tree-canopied streets, creating an elegant atmosphere. The quiet neighborhood offers peaceful strolls along uncrowded sidewalks. Visitors appreciate the area's authentic residential character and meticulously maintained properties. While dining and shopping require a short trip to downtown, the neighborhood's charm lies in its historic bed & breakfasts with period furnishings. Downtown Rochester's attractions remain just minutes away by car.
East Side Pioneers
East Side Pioneers offers Rochester visitors a peaceful suburban retreat away from the downtown bustle. Tree-lined streets and single-family homes create a calm atmosphere for those seeking quiet after busy days. Parks like Mayo and Silver Lake provide natural escapes within this family-oriented area. The neighborhood serves as an affordable base for Mayo Clinic patients needing extended stays. Though dining options are limited locally, downtown Rochester's restaurants are just a short drive away. Art enthusiasts can visit the nearby Rochester Art Center and Civic Theater for a taste of local culture.

Slatterly Park
Slatterly Park neighborhood offers a peaceful retreat with tree-lined streets and charming mid-century homes. Rochester locals walk their dogs along shaded sidewalks while children play in the central park. Historic architecture tells the story of this authentic residential area away from the medical center hustle. The namesake park serves as a community hub with open green lawns, playgrounds, and walking paths. Architecture enthusiasts will appreciate the diverse styles from Craftsman bungalows to Colonial Revival homes. Downtown attractions like the Rochester Art Center and Mayo Civic Center are just a short drive away.
Stay near popular Rochester attractions
Rochester and related destinations
Home to the world-famous Mayo Clinic, this city offers surprising cultural richness with its vibrant downtown art scene and Plummer Building tours. Explore the peaceful Quarry Hill Nature Center trails in morning hours, then sample local craft beers at one of the breweries along Historic 3rd Street.

Top Rochester Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic
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