South San Diego Vacations

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Where to stay in South San Diego

Find the best South San Diego areas and neighborhoods for the activities you enjoy most. Learn more about South San Diego
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Otay Mesa West

Even though there aren't top sights in Otay Mesa West, you can explore the larger area and take in top sights like San Ysidro Border Crossing. Jump on the metro at Iris Avenue Trolley Station to see more of the city.

Find hotels in Otay Mesa West

Find the Best South San Diego Vacation Packages

South San Diego Hotel Deals

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is ₩180,208 per night from Dec 29 to Dec 30
₩180,208
₩259,040 total
Dec 29 - Dec 30
includes taxes & fees
8.2/10 Very Good! (3,171 reviews)
Conveniently located to airport and town.

Reviewed on Dec 25, 2025

Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is ₩154,402 per night from Jan 5 to Jan 6
₩154,402
₩177,477 total
Jan 5 - Jan 6, 2026
includes taxes & fees
9/10 Wonderful! (3,209 reviews)
Everything was wonderful

Reviewed on Dec 24, 2025

Bay Club Hotel & Marina
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is ₩149,933 per night from Jan 4 to Jan 5
₩149,933
₩173,840 total
Jan 4 - Jan 5, 2026
includes taxes & fees
8.8/10 Excellent! (793 reviews)
Staff members were very helpful. Nice property.

Reviewed on Dec 25, 2025

The DEXTRO Little Italy, BW Premier Collection
See all 7,805 properties in South San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in South San Diego

Kaiser Permanente Otay Mesa Medical Offices

4.5/5(3 reviews)

Though Kaiser Permanente Otay Mesa Medical Offices might be what brings you to town, perhaps you'll have a chance to explore more of San Diego while you are here.

Kaiser Permanente Otay Mesa Medical Offices

Atlantis Laser Tag

You can take time to visit Atlantis Laser Tag during your travels to Chula Vista. Wander the waterfront and beautiful beaches in this family-friendly area.

Atlantis Laser Tag

Frequently asked questions

Can I cancel my flight booking to South San Diego due to COVID-19?
If you haven't booked yet, go over the terms and conditions of the airfare you're considering. If you've already secured your flight to South San Diego, visit our Customer Service Portal. It has information that will help determine which COVID-19 policies apply to your reservation and provide you with the next steps.
What's the best way to find cheap flights to South San Diego that have flexible change policies?
By using our helpful "No change fee" filter, that's how. Just type in your travel details, click the "Search" button, then tick the checkbox directly underneath the "Flexible change policies" subheading (it's on the left). Expedia makes it a cinch to find cheap, flexible tickets to South San Diego.
What are some of the general tips for travelers to South San Diego during the COVID-19 outbreak?
If it's your first time traveling during COVID-19, you'll notice a few more regulations and rules in place. Follow these tips and make your escape to South San Diego a smooth one:
  • Research what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so make sure you check before you lock in your flight.
  • You're required to wear a face mask throughout your travel experience, even at screening checkpoints. You should be prepared to lower your mask for ID purposes when asked.
  • You're no longer required to hand your boarding pass (paper or electronic) directly to a TSA officer. Rather, position the pass on the reader and then hold it up so the agent can inspect it.
  • TSA is now allowing passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on luggage. This will need to be removed from your bag for X-ray screening.
  • Put any personal items (phone, wallet and keys) in your carry-on rather than a bin to reduce handling during the screening process.
  • If you're taking food on the plane, place it in a clear plastic bag and then into a scanning bin. This reduces the likelihood that a TSA officer will need to touch your food container or carry-on bag for closer inspection.

Which airlines fly to South San Diego?
American Airlines is a top carrier servicing South San Diego. Search for airfares to San Diego Intl. Airport (SAN) and you'll have 759 American Airlines flights every month to pick from.
How can I find cheap tickets to South San Diego?
One of the best ways to snare cheap tickets to South San Diego is to be flexible with your travel dates. Search for your flights, then click "flexible dates" above the results. You'll see the cheapest prices for nearby days. The lowest price for a flight to South San Diego in the last seven days was . Booking ahead will usually help you get an even bigger bargain.
How much is a flight to South San Diego?
You could have snapped up a return air ticket to South San Diego from anywhere between and in the last seven days. For one-way journeys from (), the lowest price during this period was just .
What are the most popular airports to fly into in South San Diego?
Start organizing your South San Diego escape by booking a ticket on one of the 6709 monthly flights to San Diego Intl. Airport (SAN). This is the region's main point of entry.
When is the cheapest time to fly to South San Diego?
If you'd rather spend your vacation cash exploring South San Diego rather than on your journey there, jet off earlier in the week. The most affordable day to fly is normally Tuesday, with Monday close behind. With many people traveling over the weekend, Saturday typically has the costliest fares.
How much is a plane ticket to South San Diego?
In the last seven days, plane tickets to South San Diego varied between and . Prices generally depend on the departure time, seating class, airline and when the fare is booked.
Which airlines with flights to South San Diego employ COVID-19 cleanliness policies?
While traveling during the COVID-19 pandemic can be challenging, airlines are doing their utmost to protect the well-being of customers and crew. Here are a few carriers that have implemented changes:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Alaska Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.