The Best Resorts & Hotels with Spas in South Side, PA from ₩449,389 in 2026

A park with autumn trees, a bridge, and a building labeled UPMC in the background.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on South Side Resorts & Hotels with Spas

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for South Side hotels with a spa

Couples treatment rooms, sauna, steam room, body treatments

Suite, 1 Bedroom | Bathroom | Separate tub and shower, deep soaking tub, designer toiletries

Executive Suite, 1 King Bed with Sofa bed, River View | Minibar, in-room safe, desk, blackout drapes

1. Fairmont Pittsburgh

Downtown Pittsburgh

Rejuvenate at this downtown luxury hotel featuring 4 couples spa treatment rooms and full-service wellness facilities.

₩406,872

₩463,834 total

includes taxes & fees

Aug 20 - Aug 21

2. The Inn on Negley

Shadyside

Unwind at this Victorian inn with serene garden views and Swedish massages for a peaceful retreat in the heart of Pittsburgh.

₩394,201

₩449,389 total

includes taxes & fees

Aug 11 - Aug 12

View all properties

Choose what matters most at spa hotels in South Side

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top South Side Hotel Reviews

Omni William Penn Hotel

10/10 Excellent

"My wife and I were in town for our anniversary and our stay at the Omni Hotel was very pleasant. Staff was very friendly and helpful with directions and best ways to get around town. We stopped by the tavern to get a quick bite one late afternoon and the waitress did not only provide great service but was extremely knowledgeable about the history of Pittsburgh and the Omni hotel… oh yeah and the food was good as well :) We would definitely recommend the hotel as it is not too expensive and near many attractions. Well worth the stay!"