Southeast Minnesota Vacations

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Where to stay in Southeast Minnesota

Find the best Southeast Minnesota areas and neighborhoods for the activities you enjoy most. Learn more about Southeast Minnesota
Rochester showing skyline and a city

Downtown Rochester

2 out of top 10 points of interest in this area
4.5/5(250 area reviews)

If you're spending some time in Downtown Rochester, Mayo Civic Center and Rochester Art Center are top sights worth seeing.

Find hotels in Downtown Rochester

Find the Best Southeast Minnesota Vacation Packages

Southeast Minnesota Hotel Deals

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is ₩108,076 per night from Jul 27 to Jul 28
₩108,076
₩124,423 total
Jul 27 - Jul 28
includes taxes & fees
8/10 Very Good! (944 reviews)
"Nice large rooms, good dining options on site"

Reviewed on Jul 21, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is ₩176,459 per night from Jul 23 to Jul 24
₩176,459
₩203,148 total
Jul 23 - Jul 24
includes taxes & fees
8.2/10 Very Good! (1,459 reviews)
"Nice stay, convient. Very clean"

Reviewed on Jul 16, 2025

Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw, Rochester, MN
Fully refundableReserve now, pay when you stay
The price is ₩110,701 per night from Aug 8 to Aug 9
₩110,701
₩127,451 total
Aug 8 - Aug 9
includes taxes & fees
7.8/10 Good! (1,009 reviews)
"Staff were friendly and helpful."

Reviewed on Jul 19, 2025

Med City Inn & Suites - Mayo Clinic Area
See all 922 properties in Southeast Minnesota
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southeast Minnesota

Mayo Clinic Hospital - Saint Marys Campus

4.5/5(391 reviews)

Though Mayo Clinic Hospital - Saint Marys Campus might be what brings you to town, perhaps you'll have a chance to explore more of Rochester while you are here.

Mayo Clinic Hospital - Saint Marys Campus

Frequently asked questions

How much does a Southeast Minnesota vacation package cost?
Our Southeast Minnesota vacation packages, which start from as low as , are an ideal way to save. Select your favorite flights, hotels and rental cars to create a personalized itinerary.
How do I get a cheap travel package to Southeast Minnesota?
Bundle your flights and hotels with Expedia to save on your next exciting adventure. With more than 550 partner airlines and 1,000,000 properties across the globe, your Southeast Minnesota vacation package can be tailored exactly to suit your travel style. With all those extra dollars, why not add a few interesting activities and tours? It's an easy way to unlock even more discounts. The vacation you've always dreamed of in Southeast Minnesota is much closer than you thought!
What are the top hotels in Southeast Minnesota?
For hotels in Rochester with comfy beds and friendly service, you can't go past Kahler Inn and Suites - Mayo Clinic Area and Kahler Grand Hotel. If you plan to visit Lake City as well, you'll get a great night's sleep at Pet - Friendly Wabasha Studio: Boat or Peaceful Condo In Wabasha With Beautiful River Bluff Location - Lower Unit.
How far in advance should I book my Southeast Minnesota vacation?
Travelers are usually able to browse international airfares on Expedia within 12 months of the departure date. Booking last minute? With a little bit of luck, it's still possible to score an affordable ticket only weeks before your flight.
What does an Expedia Southeast Minnesota travel package include?
It's up to you! You can select from a range of Southeast Minnesota bundles, such as a flight, hotel and rental car. You can also book a hotel with a flight, or a rental car with a flight. Once you've made your booking, you can add the fun stuff like activities and experiences. Whatever your perfect Southeast Minnesota getaway looks like, you'll save!
What should I know before booking a Southeast Minnesota travel package?
Our prices are always low. However, you'll grab even more savings if you book your flights, hotels and car rentals together. With an Expedia travel package, you'll always get transparent pricing and lots of choice.
Can I choose my airline with a Southeast Minnesota Expedia vacation package?
Yes, you sure can. We have more than 550 partner airlines across the globe, so pick the carrier that fits your travel needs.
If I'm not able to travel, can I cancel my Southeast Minnesota vacation package?
It's impossible to predict what the future holds, so it's comforting to know that you can cancel or change your Southeast Minnesota vacation package. If your booking was made in the last 24 hours, you may be entitled to a refund. If it's an older booking, your hotel, airline or car rental company may charge a fee. Visit our Customer Service Portal for further details.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.