Plan, book, travel with confidence
Better together
Save up to ₩234,741 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Adventure Mesopotamia Hotels

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

9/10 Wonderful! (607 reviews)

Wow, room was wonderful. Property was clean , pools wonderful. Spa was great. Breakfast was awesome. But most of all. Staff were super. Every question answered! All requests granted and always courteous and professional!

Reviewed on Jan 23, 2026

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Book a stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff and the property ...

9.8/10 Exceptional! (1,005 reviews)

The hotel is in an amazing location, right near the falls and gives you access to the park out of hours to enjoy sunset over the falls or just to explore without the crowds.

Reviewed on Jan 25, 2026

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

9.2/10 Wonderful! (1,012 reviews)

This is an excellent hotel inside the national park. The staff is very friendly and provide top tier service. They also upgraded our room to water fall view room which has a stunning view of the fall. The experience is superior!

Reviewed on Jan 25, 2026

See all 494 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.