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Top Honeymoon Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (504 reviews)

Felt like i was being transported back in time. Great old world service from the moment you enter. Missed out on the 5 course breakfast but the owners graciously got up early to prepare me a breakfast and coffee to go.

Reviewed on May 11, 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.4/10 Very Good! (208 reviews)

Dan, the manager was so friendly and accommodating!

Reviewed on May 4, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,004 reviews)

Our sink didn't drain The shower didn't drain but the stopper didn't work, the cold water kept coming out of shower, so it didn't work to shower or take a bath

Reviewed on May 2, 2026

See all 1,205 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.