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Top Luxury Northeast Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Treat yourself to some luxurious accommodations at The Royal Sonesta Chase Park Plaza St. Louis, where you can enjoy amenities like pillowtop beds, designer ...

8.8/10 Excellent! (1,002 reviews)

Location is within walking distance of grocery stores, restaurants, and local shops. Valet is $50/day, self park is $40/day. On-site restaurants are great, steakhouse was excellent but very expensive. Only negatives were no full length mirror in the room, only mirror was behind sink in bathroom, ...

Reviewed on Dec 14, 2025

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay in the lap of luxury at Ameristar Casino Resort and Spa, where you can enjoy amenities like plush bedding, HDTVs, and more. Notable amenities include a ...

8.4/10 Very Good! (1,005 reviews)

Welp, it wasn’t spotless per say, however, I am not displeased at all.

Reviewed on Dec 12, 2025

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Be treated to a luxury stay at The Ritz-Carlton, St. Louis, where you can enjoy amenities like plush bedding, designer toiletries, and more. The 3 bars, fitness ...

9.2/10 Wonderful! (553 reviews)

Absolutely beautiful hotel!!! Highly recommend!

Reviewed on Nov 28, 2025

See all 2,789 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.