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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

9.8/10 Exceptional! (514 reviews)

"Richard was a wonderful host. The mansion was clean and the front porch was wonderful! (A little noisy as it is on a busy street). Breakfast was amazing!! Be prepared to spend some time at breakfast. Overall a great stay, and would stay again!"

Reviewed on Jun 16, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,011 reviews)

Couples like: full-service spa, bar

Travelers say...

"Loved it"

Reviewed on Jun 15, 2026

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (752 reviews)

"Everything was clean. Beds were a little soft for our liking, but still comfortable. Bathroom in 2 queen room was TINY."

Reviewed on Jun 13, 2026

See all 1,175 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.