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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

9.8/10 Exceptional! (564 reviews)

"Wonderful host Richard and the beautiful home"

Reviewed on Nov 2, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,003 reviews)

Couples like: full-service spa, bar

Travelers say...

"It was so full of history. Great location near small shops within walking distance. Doing some renovations and looking forward to return to see the outcome!"

Reviewed on Nov 2, 2026

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (810 reviews)

"The rooms were very dated and not very comfortable. The bed and pillows were very uncomfortable."

Reviewed on Nov 3, 2026

See all 1,247 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.