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Top Adventure Mesopotamia Hotels

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

9.2/10 Wonderful! (666 reviews)

"5-star property with well-maintained lush garden and pool and amazing staff. Special kudos to front desk staff (David and Gabriel), porters (Bruno and Gonzalo) and concierge (Fabio). Very satisfied with our 2-night stays."

Reviewed on May 30, 2026

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Book a stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff and the property ...

9.8/10 Exceptional! (1,022 reviews)

"The organisation and attentiveness of the staff was absolutely top rated. Even if they got something wrong they came over and apologised and made it clear they would try harder. I have never seen such a positive and open way to continually improve things. Room servicing was attentive and discrete. ..."

Reviewed on Jun 13, 2026

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...

9.4/10 Exceptional! (1,007 reviews)

"Una vez echo mi check in fui a la habitación y no me gustó, le pregunté si el hotel estaba completo y nos dijeron que un diez porciento, ahí vino mi pregunta que siendo miembro de Expedia golf teníamos acceso a un upgrade si está disponible obviamente lo cual negaron , les dije que mi hicieran igual ..."

Reviewed on Jun 13, 2026

See all 524 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.