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Top Luxury Mesopotamia Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...

9.8/10 Exceptional! (1,019 reviews)

This is the most enjoyable experience we have ever had in a hotel. The location by the Iguaçu Falls and the property, service and good were impeccable

Reviewed on May 1, 2026

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Pamper yourself with a luxury stay at Iguazu Grand Resort Spa & Casino, where you can enjoy amenities like Champagne service, massage services, and more. The ...

9/10 Wonderful! (655 reviews)

Relaxing, safe, very nice staff.

Reviewed on May 7, 2026

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Go for a luxurious stay at Gran Melia Iguazú, where you can enjoy amenities like massage services, Egyptian cotton sheets, and more. Deluxe amenities at this ...

9.4/10 Exceptional! (1,002 reviews)

The whole experience was perfect. The first things you see when entering the hotel are the waterfalls - such an amazing view. The staff was truly lovely as well. Being able to get up in the morning to be the first in the park was such a pleasure. Highly recommend this hotel.

Reviewed on May 10, 2026

See all 519 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.