Antofagasta Region Vacations & Trips

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Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460 San Pedro de Atacama Antofagasta
The price is ₩170,661 per night from Nov 18 to Nov 19
₩170,661
₩170,661 total
Nov 18 - Nov 19
8.2/10 Very Good! (414 reviews)
"excellent location, well maintained property. Rooms basic but good. Well stocked breakfasts. Recommend."

Reviewed on Nov 5, 2026

Diego de Almagro San Pedro de Atacama
Geotel Calama

Geotel Calama

3.5 out of 5
Cobija 2273 Calama Antofagasta
The price is ₩100,485 per night from Dec 5 to Dec 6
₩100,485
₩100,485 total
Dec 5 - Dec 6
8.8/10 Excellent! (244 reviews)
"Chambre très confortable, petit déjeuner complet et stationnement sécurisé. Tout etait parfait"

Reviewed on Nov 8, 2026

Geotel Calama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18 San Pedro de Atacama
9.2/10 Wonderful! (468 reviews)
"We spent 5 nights at El Refugio La Casa de Don Tomas and thoroughly enjoyed our stay. The entire property was exceptionally clean, with great facilities, a beautiful garden area, and a fantastic terrace that was perfect for viewing the night sky. The staff were remarkably friendly and welcoming, ..."

Reviewed on Nov 9, 2026

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Hotel La Casa de Don Tomas
See all 304 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Antofagasta Region vacation package cost?
From as low as . Yes, you read that right. Our Antofagasta Region packages are the best way to stretch your budget. Combine your hotels, flights and car rentals and discover this lively destination.
How do I get a cheap travel package to Antofagasta Region?
Our Antofagasta Region vacation packages promise plenty of savings for the savvy traveler. For the best deals, simply bundle your hotel, flights and activities into an affordable package. But impressive bargains are only the start of your next unforgettable adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 properties throughout the world to pick from. Whatever your budget, there's a package that's perfect for you.
What are the top hotels in Antofagasta Region?
Have a look at ibis Antofagasta and NH Antofagasta. They're the first choice for lots of travelers to Antofagasta. If San Pedro de Atacama is on your travel itinerary, Park Hotel Calama and Noi Casa Atacama are cozy options.
How far in advance should I book my Antofagasta Region vacation?
It can be tricky to know when is the ideal time to book your trip to Antofagasta Region. But typically the earlier you book, the better the prices. Sometimes, you can reserve your flights and hotels up to a year before your departure date. If you're considering a last-minute getaway, no need to stress! There are fabulous deals featured on Expedia every single day.
What does an Expedia Antofagasta Region travel package include?
From hotels and airfares to rental cars, Expedia can help you shape an Antofagasta Region package that's perfect for you. Vacationing for a week or two? Consider a rental car, hotel and flight bundle. If you're taking a short break, a flight and hotel deal could be more your style. Activities can also be added once you've made your booking. Our vacation packages make it simple to save and plan.
What should I know before booking an Antofagasta Region travel package?
Tailor deals to suit your budget with an Expedia package. Airfares, hotels, rental cars — we're a one-stop shop for all of them. You'll save precious dollars just for bundling your bookings. Whether you're embarking on a skiing adventure or drinking cocktails on a beach, your perfect getaway is just clicks away.
Can I choose my airline with an Antofagasta Region Expedia vacation package?
Expedia has access to more than 550 airline partners worldwide, so you sure can! Simply select your preferred carrier and put together the perfect Antofagasta Region trip.
If I'm not able to travel, can I cancel my Antofagasta Region vacation package?
Whether it's your flight or hotel, you can cancel and rebook it. Locked in your Antofagasta Region vacation package in the last 24 hours? You may be able to make changes at no cost. For bookings older than that, you may be charged a fee by your hotel, airline or car rental company. For further information, visit our Customer Service Portal. We'll help you every step of the way.

Stay near popular Antofagasta Region attractions

Valley of the Moon

9.2/10 (244 reviews)
Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.