What's it like in Lake Nona Medical City?

Lake Nona Medical City is a neighborhood that travelers like for its restaurants.

What's a favorite place to stay in Lake Nona Medical City?

Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favorite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona .

How many hotels are there in Lake Nona Medical City?

Expedia has 5 Lake Nona Medical City hotels and other accommodations, and one might make a good home base for venturing out into the greater Orlando area.

If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?

Yes, the majority of hotel reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to review the best options available in Lake Nona Medical City.

Where can I learn more about changing or cancelling my trip to Lake Nona Medical City?

For more information about changing or cancelling your trip to Lake Nona Medical City, click here .

What is there to do around this Orlando neighborhood?

Eagle Creek Golf Club, USTA National Campus, and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.

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Dates

March 2026

11

April 2026

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Our top choices for Lake Nona Medical City hotels

Courtyard Orlando Lake Nona

Lake Nona Medical City

Jana

₩281,522 total

includes taxes & fees

Apr 3 - Apr 4

Aloft Orlando Lake Nona

Lake Nona Medical City

Kendra

₩229,258 total

includes taxes & fees

Apr 5 - Apr 6

Residence Inn Orlando Lake Nona

Lake Nona Medical City

David

₩313,182 total

includes taxes & fees

Apr 5 - Apr 6

Meliá Orlando Celebration

26.1 km from Lake Nona Medical City

Brad

₩206,334 total

includes taxes & fees

Mar 30 - Mar 31

The Delaney Hotel

South Orange, 20.2 km from Lake Nona Medical City

Cate

Courtyard by Marriott Orlando Downtown

23.1 km from Lake Nona Medical City

John

₩237,504 total

includes taxes & fees

Mar 22 - Mar 23

Comfort Suites Downtown

24.8 km from Lake Nona Medical City

DWIGHT

₩196,896 total

includes taxes & fees

Apr 5 - Apr 6

Wyndham Lake Buena Vista – Disney Springs® Area

23.2 km from Lake Nona Medical City

Yukari

₩255,653 total

includes taxes & fees

Mar 22 - Mar 23

Wyndham Garden Lake Buena Vista – Disney Springs® Area

23.2 km from Lake Nona Medical City

Audrey Nou

₩222,989 total

includes taxes & fees

Mar 22 - Mar 23

Mini-fridge, microwave, coffee/tea maker

AC Hotel by Marriott Orlando Lake Buena Vista

22.5 km from Lake Nona Medical City

Michelle

₩187,859 total

includes taxes & fees

Mar 22 - Mar 23

Staybridge Suites Orlando at SeaWorld by IHG

19.7 km from Lake Nona Medical City

Dianne

₩192,972 total

includes taxes & fees

Mar 23 - Mar 24

Hilton Vacation Club Grand Beach Orlando

21.7 km from Lake Nona Medical City

Jeannette

₩271,322 total

includes taxes & fees

Mar 23 - Mar 24

Outdoor pool, sun loungers, lifeguards on site

Spectrum Resort Villas Orlando and Waterparks

33 km from Lake Nona Medical City

Donna

₩661,872 total

includes taxes & fees

Mar 22 - Mar 23

Westgate Vacation Villas Resort

31.4 km from Lake Nona Medical City

Jessica Latoya

₩197,868 total

includes taxes & fees

Mar 12 - Mar 13

Element Orlando Universal Blvd.

International Drive District, 20.7 km from Lake Nona Medical City

Sakinah

₩159,819 total

includes taxes & fees

Mar 22 - Mar 23

Days Inn by Wyndham Orlando Conv. Center/International Dr

International Drive District, 19.2 km from Lake Nona Medical City

Eva

₩127,659 total

includes taxes & fees

Mar 29 - Mar 30

Aloft Orlando Lake Buena Vista

21.7 km from Lake Nona Medical City

Terry

₩148,438 total

includes taxes & fees

Mar 22 - Mar 23

Fairfield Inn & Suites Orlando Lake Buena Vista

22.8 km from Lake Nona Medical City

Blenda

₩166,582 total

includes taxes & fees

Apr 5 - Apr 6

SPOT X Hotel Orlando/Intl Dr by The Red Collection

21 km from Lake Nona Medical City

Emel

₩145,274 total

includes taxes & fees

Mar 25 - Mar 26

Drury Plaza Hotel Orlando - Disney Springs Area

22.9 km from Lake Nona Medical City

BARRY

₩266,350 total

includes taxes & fees

Apr 5 - Apr 6

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Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most.

Visiting Aquatica water park in Orlando, Florida, enjoying thrilling water slides and attractions

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

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This is the third park built at the Walt Disney World Resort, opening on May 1, 1989 as Disney-MGM Studios. Today, it's known as Disney's Hollywood Studios.

Bay Lake

Home to all four Walt Disney World Resort theme parks and one water park, this city offers endless entertainment, including Disney's Fort Wilderness Resort & Campground and Magnolia and Palm Golf Courses.

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Champions Gate

Abundant dining options and pristine golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

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Hollywood Rip Ride Rock it at Universal Studios, Orlando.
Taken on a Sony a6000 with a 16 mm Sony lens.
# TroveonTuesday

Florida Center

While visiting Florida Center, you might make a stop by sights like Universal Orlando Resort and Universal Studios Florida.

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Orlando downtown welcome sign with tropical scene; Shutterstock ID 99801884

Downtown Orlando

Orlando's historic core boasts art galleries, retail, restaurants, and nightclubs, with attractions like Lake Eola Park, Linton E. Allen Memorial Fountain, and performing arts theaters, all accessible via public transportation.

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Top Lake Nona Medical City Hotel Reviews

Kompose Boutique Resort at Theme Parks

10/10 Excellent

"Yhe hotel was great. Highly recommend. "

CoCo Key Hotel and Water Resort

2/10 Terrible

"Only good thing about this place is that it’s close by to many things . But do not book this place , building is old . Found roaches in my room , loud music in the pool with drunk people dancing and hogging the pool as if they own the place . Weekend proved to be full of ratchet rats . Waterpark is fun for kids but do not stay here unless you want a roach infested room . Night staff at the front were very professional when addressing a problem. But morning staff could care less they stare at you like seeing roaches is normal here . I won’t stay here again . "

Universal's Cabana Bay Beach Resort

10/10 Excellent

"The property is such a beautiful place that brings you back to your childhood memories. They have all the amenities you need for your family which was very accommodating and a shuttle to take you to universal studios right outside the hotel. This is our second time at this hotel and would definitely recommend it to anyone."

Westgate Lakes Resort & Spa Universal Studios Area

10/10 Excellent

"I really enjoyed the property my mom used to work at Westgate lake resorts and I used to drop her off and pick her up but I never stayed on the property well she died in 2015 so my recent stay was very nostalgic for me I thought about her the entire time I enjoyed the room so much I didn't go anywhere"

Find hotels in Lake Nona Medical City, Orlando

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Treat yourself

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Our top choices for Lake Nona Medical City hotels

Courtyard Orlando Lake Nona

Aloft Orlando Lake Nona

Residence Inn Orlando Lake Nona

Meliá Orlando Celebration

The Delaney Hotel

Courtyard by Marriott Orlando Downtown

Comfort Suites Downtown

Wyndham Lake Buena Vista – Disney Springs® Area

Wyndham Garden Lake Buena Vista – Disney Springs® Area

AC Hotel by Marriott Orlando Lake Buena Vista

Staybridge Suites Orlando at SeaWorld by IHG

Hilton Vacation Club Grand Beach Orlando

Spectrum Resort Villas Orlando and Waterparks

Westgate Vacation Villas Resort

Element Orlando Universal Blvd.

Days Inn by Wyndham Orlando Conv. Center/International Dr

Aloft Orlando Lake Buena Vista

Fairfield Inn & Suites Orlando Lake Buena Vista

SPOT X Hotel Orlando/Intl Dr by The Red Collection

Drury Plaza Hotel Orlando - Disney Springs Area

Where to stay in Lake Nona Medical City

International Drive District

Bay Lake

Champions Gate

Florida Center

Downtown Orlando

Top Lake Nona Medical City Hotel Reviews

Kompose Boutique Resort at Theme Parks

Frequently asked questions

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