Downtown South San Francisco, CA

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Downtown South San Francisco Hotel Deals

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
Fully refundableReserve now, pay when you stay
The price is ₩160,507 per night from Sep 10 to Sep 11
₩160,507
₩187,918 total
Sep 10 - Sep 11
includes taxes & fees
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast ...
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ₩204,494 per night from Sep 7 to Sep 8
₩204,494
₩240,691 total
Sep 7 - Sep 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ₩202,404 per night from Sep 18 to Sep 19
₩202,404
₩294,189 total
Sep 18 - Sep 19
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (7,652 reviews)
"The hotel was clean and comfortable. The bathroom on the other hand was so small that you had to straddle the toilet just to close the door. But it was clean and functional. Would I stay there again? Sure if I ever come back to SF. Did we try the breakfast buffet that came with the room rate, no. ..."

Reviewed on Sep 3, 2026

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
The price is ₩228,321 per night from Oct 2 to Oct 3
₩228,321
₩268,723 total
Oct 2 - Oct 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful ...
Hilton San Francisco Union Square
The Pickwick Hotel

The Pickwick Hotel

3.5 out of 5
85 5th St San Francisco CA
The price is ₩131,435 per night from Sep 8 to Sep 9
₩131,435
₩154,436 total
Sep 8 - Sep 9
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
The Pickwick Hotel
Club Quarters Hotel Embarcadero, San Francisco

Club Quarters Hotel Embarcadero, San Francisco

4 out of 5
424 Clay St San Francisco CA
The price is ₩182,842 per night from Sep 7 to Sep 8
₩182,842
₩215,196 total
Sep 7 - Sep 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
Club Quarters Hotel Embarcadero, San Francisco
See all 4,220 properties in Downtown South San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most.
A street with shops, including a crystal shop and a crepes cafe.

Fisherman's Wharf

Pier 39 and San Francisco Bay are top sights in Fisherman's Wharf, and you should be sure to explore the popular shops. Hop aboard the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop to see more sights in the area.

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops, and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

A cityscape with modern skyscrapers, a central park with pathways, and a few people walking.

South of Market

Oracle Park and Chase Center are top sights in South of Market, and you should be sure to explore the popular shops. Hop aboard the metro at Yerba Buena-Moscone Station or Fourth-Brannan Station to see more sights in the area.

A street lined with historic buildings, parked cars, and a clear blue sky.

Nob Hill

Travelers love Nob Hill for its popular shops, and you can see more of San Francisco by jumping on the metro at Washington St & Leavenworth St Stop or Washington St & Jones St Stop. You might spend time checking out top sights like SF Masonic Auditorium and Cable Car Museum.

Downtown South San Francisco, CA