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Check prices for these dates

This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

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Our top choices for Downtown South San Francisco hotels

A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.2 out of 10, Very good, (2,140 reviews)
"Nice, clean hotel with a great breakfast very conveniently located near the airport."
United States
Justin
The price is ₩158,395
₩185,419 total
includes taxes & fees
Nov 14 - Nov 15
La Quinta Inn & Suites by Wyndham San Francisco Airport N
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.

2. Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
9.0 out of 10, Wonderful, (1,003 reviews)
"One of the best places I’ve stayed in SF area"
United States
Saikiran
The price is ₩153,271
₩179,206 total
includes taxes & fees
Nov 20 - Nov 21
Airport Inn
A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.

3. Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.2 out of 10, Good, (23 reviews)
"Old house, poorly maintained. I won’t be coming back"
United States
Lou
The price is ₩71,877
₩185,086 total
includes taxes & fees
Oct 22 - Oct 23
Miller Apartments
A hotel room with a bed, a desk, a chair, a TV, and a lamp.

4. Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.6 out of 10, Good, (1,000 reviews)
"Awesome place staff was very helpful and friendly room was clean and well organized 10 out of 10"
United States
desmon
Inn By The SFO
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
3.5 star property
The East Side, 1.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,820 reviews)
"This hotel is very clean and updated. We enjoyed the indoor pool and the breakfast was amazing. Would definitely stay here again."
United States
Tonya
The price is ₩184,162
₩216,394 total
includes taxes & fees
Nov 13 - Nov 14
Embassy Suites by Hilton San Francisco Airport Oyster Point
A courtyard with outdoor seating, a glass table, and potted plants.

6. Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
2.5 star property
The East Side, 1.1 km from Downtown South San Francisco
7.8 out of 10, Good, (1,003 reviews)
"Shuttle was very fast."
United States
Brenda
The price is ₩142,156
₩166,729 total
includes taxes & fees
Oct 31 - Nov 1
Comfort Inn and Suites San Francisco Airport North
A hotel room with a bed, desk, chair, television, and a microwave.

7. Hotel Nova SFO

Hotel Nova SFO
2.5 star property
1.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,008 reviews)
"Nice and simple stay! Great service and staff. Definitely recommend."
United States
Daniel
The price is ₩167,712
₩195,784 total
includes taxes & fees
Oct 24 - Oct 25
Hotel Nova SFO
A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.

8. Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
3.0 star property
1.8 km from Downtown South San Francisco
8.4 out of 10, Very good, (1,918 reviews)
"We enjoyed the hospitality of staff and the breakfast was great & always stocked !"
United States
Mechelle
The price is ₩151,686
₩178,525 total
includes taxes & fees
Nov 6 - Nov 7
Best Western Plus Grosvenor Airport Hotel
A hotel lobby with a central reception desk, large columns, and hanging pendant lights.

9. Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
3.0 star property
The East Side, 1.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,007 reviews)
"Staff were helpful, polite and made sure my stay was comfortable."
United States
kathrina
The price is ₩129,884
₩152,624 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Garden Inn San Francisco Arpt North
A hotel room with a bed, a sofa, a nightstand, and a desk. There are three framed pictures on the wall.

10. The Atrium Hotel

The Atrium Hotel
2.5 star property
3 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,025 reviews)
"The room was clean and comfortable, and the staff were friendly and welcoming with a smile. It was a great place to stay, especially with the convenient parking and complimentary breakfast. I would definitely recommend this place!"
United States
Arceli
The price is ₩147,575
₩178,659 total
includes taxes & fees
Oct 25 - Oct 26
The Atrium Hotel
Exterior

11. Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
3.0 star property
Oyster Point, 2.2 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2,395 reviews)
"Huge rooms - loved them. The staff was kind and helpful. Had a great time. Would stay again."
United States
Sakshi
The price is ₩150,409
₩177,344 total
includes taxes & fees
Nov 1 - Nov 2
Sonesta Select San Francisco Airport Oyster Point Waterfront
A modern lobby with a cityscape mural, a reception desk, seating area, and a door with blinds.

12. Hotel Skye SFO

Hotel Skye SFO
3.0 star property
3.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,060 reviews)
"Close to SFO Breakfast included Many nice restaurants nearby Friendly staff"
United States
Terry
The price is ₩154,534
₩184,964 total
includes taxes & fees
Oct 24 - Oct 25
Hotel Skye SFO
A modern interior with a wooden partition, a stone accent wall, and a bar area.

13. DoubleTree by Hilton San Francisco Airport North Bayfront

DoubleTree by Hilton San Francisco Airport North Bayfront
4.0 star property
3.1 km from Downtown South San Francisco
8.2 out of 10, Very good, (1,793 reviews)
"Rooms were clean and the staff were amazing"
United States
Luis Alberto
The price is ₩145,723
₩171,454 total
includes taxes & fees
Oct 24 - Oct 25
DoubleTree by Hilton San Francisco Airport North Bayfront
A reception area with a counter, two patterned chairs, a yellow ottoman, and a large blue potted plant.

14. Hotel Aura SFO

Hotel Aura SFO
3.0 star property
4.4 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,638 reviews)
"Great airport stay"
United States
Charles
The price is ₩149,743
₩178,486 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Aura SFO
A hotel room with a bed, bedside lamps, a framed picture on the wall, and a vase with flowers.

15. Hotel Focus SFO

Hotel Focus SFO
3.0 star property
The East Side, 1.3 km from Downtown South San Francisco
7.6 out of 10, Good, (1,680 reviews)
"Everything was super easy from check in to breakfast to airport bus."
United States
Laurel
The price is ₩117,518
₩138,409 total
includes taxes & fees
Nov 14 - Nov 15
Hotel Focus SFO
A hotel room with a bed, bedside tables, a desk, a chair, and a large window.

16. Gateway Inn & Suites San Francisco SFO Airport

Gateway Inn & Suites San Francisco SFO Airport
2.0 star property
3.7 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,156 reviews)
"Nice and close to airport very clean rooms a great little dive"
United States
Julian
The price is ₩113,350
₩136,724 total
includes taxes & fees
Nov 8 - Nov 9
Gateway Inn & Suites San Francisco SFO Airport
A spacious, well-lit atrium with a high ceiling and skylight, featuring a central seating area with a sofa and armchairs, surrounded by a patterned rug.

17. Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
3.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (3,000 reviews)
"Wonderful place"
United States
Yazell
The price is ₩128,299
₩154,841 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Aluxor SFO
An outdoor patio with wooden furniture, a chessboard, and hanging floral decorations.

18. The Millwood - A Boutique Hotel

The Millwood - A Boutique Hotel
3.0 star property
5.4 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (1,049 reviews)
"Clean, modern and quiet motel with breakfast included. Very impressed by the quality for a small motel and for a great price!"
Canada
Alissa
The price is ₩187,505
₩223,164 total
includes taxes & fees
Oct 25 - Oct 26
The Millwood - A Boutique Hotel
A modern hotel entrance with a covered waiting area, glass doors, and a clear sky.

19. Aloft by Marriott San Francisco Airport

Aloft by Marriott San Francisco Airport
3.0 star property
6.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,296 reviews)
"Very clean and proximity to airport"
United States
Scott
The price is ₩169,043
₩194,306 total
includes taxes & fees
Nov 20 - Nov 21
Aloft by Marriott San Francisco Airport
A modern hotel lobby with a seating area, a bar, and large windows.

20. Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
16.8 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (7,741 reviews)
"Great location, breakfast was excellent."
Canada
Richard
The price is ₩165,699
₩249,857 total
includes taxes & fees
Nov 8 - Nov 9
Hotel Riu Plaza Fisherman's Wharf
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most.
A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

A city street with tall buildings, flags, and cars.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

A vibrant mural on a building, depicting a large figure with a heart-shaped halo, surrounded by various characters in colorful attire.

Mission District

Mission District is a destination travelers like for its bars, and you might hop aboard the metro at 16th Street Mission Station or 24th Street Mission Station to explore sights like SOMA Pilipinas.

Top Downtown South San Francisco Hotel Reviews

Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

10/10 Excellent
"I was taken back buy the price of 2 glasses of Chardonnay, that the server said was considered a glass and half. I felt $54 was a little steep. Other than that I was very pleased with"
Cindy Lou 4-night trip
Posted less than an hour ago
Parc 55 San Francisco - A Hilton Hotel

Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun visiting South San Francisco's Downtown South San Francisco neighborhood.
What's a favorite place to stay in Downtown South San Francisco?
Based on our traveler data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.
How many hotels will I find in the Downtown South San Francisco area?
When you want to kick up your feet after a day of exploring the sights in South San Francisco, you can choose from 11 Expedia hotels and other accommodations in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, the majority of room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals available in Downtown South San Francisco.
Where can I learn more about changing or cancelling my trip to Downtown South San Francisco?
To find more details about picking new dates or cancelling your trip to Downtown South San Francisco, head over to our customer service page.
What can I see and do in this South San Francisco neighborhood?
South San Francisco Hillside Sign, Sign Hill Park, and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.