Top Downtown South San Francisco Hotels

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Compare popular hotels in Downtown South San Francisco

Property	Property class	Guest rating
Airport Inn	2.0 star property	9.0 Wonderful 1,005 reviews	View
La Quinta Inn & Suites by Wyndham San Francisco Airport N	3.0 star property	8.2 Very good 2,145 reviews	View
Miller Apartments	2.0 star property	7.2 Good 26 reviews	View
Inn By The SFO	2.0 star property	7.6 Good 1,001 reviews	View
Galleria Park Hotel	4.0 star property	9.6 Exceptional 1,060 reviews	View

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most.

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

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A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

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A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

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A city street with tall buildings, flags, and cars.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

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A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

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Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"It was the perfect stay for my son's birthday trip. It was the perfect location, rooms were clean, staff was helpful and friendly. I highly recommend this hotel and will stay again on future trips to San Francisco."

Bay Landing San Francisco Airport Hotel

8/10 Good

"The staff, room, and view were all excellent! One star deduction because of a shuttle no-show, and calls to the hotel were all routed though a stupid AI ‘helper’ that didn’t know when the last pickup at the airport should be and we missed it, then waited a half hour for it to show up. Last pickup is at 10:30, even though the shuttle “runs” until 11 pm. Frustrating!"

Holiday Inn Golden Gateway by IHG

8/10 Good

"Thank you , Holiday Inn San Francisco!! The view from my room was BREATH TAKING ! The Hotel was clean ! Staff were all polite and extremely helpful ! And I loved all of the amenities like the pool and the gym ! I truly enjoyed all of the surrounding restaurants and nightlife just outside of the hotel ! Definitely going to book again !"

Hilton San Francisco Union Square

8/10 Good

"A Comfortable and Spacious Room, but Some Maintenance Issues ⭐⭐⭐⭐ We stayed at Hilton San Francisco Union Square for the final night of our San Francisco vacation. Despite the hotel’s impressive size and the long check-in line, the process was surprisingly efficient and well organized. Our room was spacious, clean overall, and well equipped. The heating worked perfectly, and the in-room coffee-making facilities were a welcome convenience. We particularly appreciated the exceptionally comfortable lounge chair, which provided a wonderful place to relax after a long day exploring San Francisco. However, there were some disappointing details that deserve attention. The mattress was excessively soft and appeared worn out. More concerningly, both the bedsheets and duvet covers showed considerable signs of wear, including visible holes and deteriorating fabric. These are basic comfort and quality issues that should not be overlooked at a hotel of Hilton’s reputation. Another noticeable drawback was the condition of the windows. They were extremely dirty, which significantly detracted from the enjoyment of the room and its view. Despite these shortcomings, we appreciated the spacious accommodation, comfortable lounge chair, effective heating, and convenient amenities. Overall, we had a pleasant stay, but better maintenance, replacement of worn bedding, and more thorough window cleaning would make a significant difference. Four stars for a generally comfortable experience"

Frequently asked questions

What's it like in Downtown South San Francisco?

You'll be sure to have fun visiting South San Francisco's Downtown South San Francisco neighborhood.

What's a favorite place to stay in Downtown South San Francisco?

Based on our traveler data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.

How many hotels will I find in the Downtown South San Francisco area?

When you want to kick up your feet after a day of exploring the sights in South San Francisco, you can choose from 11 Expedia hotels and other accommodations in Downtown South San Francisco.

If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

Yes, the majority of room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals available in Downtown South San Francisco.

Where can I learn more about changing or cancelling my trip to Downtown South San Francisco?

To find more details about picking new dates or cancelling your trip to Downtown South San Francisco, head over to our customer service page.

What can I see and do in this South San Francisco neighborhood?

South San Francisco Hillside Sign, Sign Hill Park, and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.

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Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

2. Airport Inn

3. Miller Apartments

4. Inn By The SFO

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

6. Comfort Inn and Suites San Francisco Airport North

7. Hotel Nova SFO

8. Best Western Plus Grosvenor Airport Hotel

9. Home2 Suites by Hilton San Francisco Airport North

10. Hilton Garden Inn San Francisco Arpt North

11. Sonesta Select San Francisco Airport Oyster Point Waterfront

12. The Atrium Hotel

13. Hotel Skye SFO

14. Hotel Aura SFO

15. The Dylan at SFO

16. DoubleTree by Hilton San Francisco Airport North Bayfront

17. Hotel Nikko San Francisco

18. Hotel Focus SFO

19. LUMA Hotel San Francisco

20. Hotel Aluxor SFO

Compare popular hotels in Downtown South San Francisco

Where to stay in Downtown South San Francisco

Union Square

Downtown San Francisco

Fisherman's Wharf

South of Market

Nob Hill

Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

Frequently asked questions

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