Downtown South San Francisco Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ₩234,741 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown South San Francisco
Union Square which includes a high rise building and a city

Union Square

4/5(5,164 area reviews)

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Find hotels in Union Square

Downtown South San Francisco Hotel Deals

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is ₩143,990 per night from Jan 5 to Jan 6
₩143,990
₩228,987 total
Jan 5 - Jan 6
includes taxes & fees
8.8/10 Excellent! (7,251 reviews)
Clean room comfortable bed and the breakfast buffet were great. It’s the holiday so it’s very busy and noisy. The walls are so thin that you can hear everything and it distrusted our sleep. And the people upstairs were stumping their feet. Good thing we were only there for 1 night.

Reviewed on Dec 29, 2025

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is ₩128,674 per night from Jan 8 to Jan 9
₩128,674
₩151,443 total
Jan 8 - Jan 9
includes taxes & fees
8.6/10 Excellent! (2,180 reviews)
Good spacious room. Very clean . Staff was very courteous. We had wonderful stay at Hilton Financial district SFO.

Reviewed on Dec 26, 2025

Hilton San Francisco Financial District
Fairmont San Francisco

Fairmont San Francisco

5 out of 5
950 Mason Street Atop Nob Hill San Francisco CA
The price is ₩325,039 per night from Jan 4 to Jan 5
₩325,039
₩450,566 total
Jan 4 - Jan 5
includes taxes & fees
9/10 Wonderful! (1,442 reviews)
It is a beautiful place to visit around the holidays, for he was a bit busy but still enjoyed our stay and the galleries inside, the Tonga Room, customer service was excellent and very kind From the lady checking us in to the valet , everyone was very helpful and cordial They make you feel like a ...

Reviewed on Dec 29, 2025

Fairmont San Francisco
See all 4,830 properties in Downtown South San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Downtown South San Francisco vacation package cost?
From just . Yes, you read that right. Our Downtown South San Francisco vacation packages are a simple way to make your dollar go further. Combine your favorite hotels, flights and car rentals and get to know this popular destination.
How do I get a cheap travel package to Downtown South San Francisco?
Bundle your bookings with Expedia to save on your next big adventure. With more than 550 airlines and 1,000,000 properties globally, your Downtown South San Francisco vacation package can be tailored exactly to suit your travel style. With all those extra dollars, why not add one or two interesting tours and activities? It's an easy way to unlock even more bargains. That dream vacation to Downtown South San Francisco is much closer than you thought!
Where should I stay in Downtown South San Francisco?
A trip to Downtown South San Francisco wouldn't be complete without seeing South San Francisco Convention Center, Sees Candies and K1 Speed San Francisco. Spend your nights close to these top attractions and make sightseeing easy.
What are the top hotels in Downtown South San Francisco?
Book a stay at Airport Inn. It's one of this area's most sought-after hotels. Another well-known option in Downtown South San Francisco is Rustic/modern Design, Oasis City Getaway.
How far in advance should I book my Downtown South San Francisco vacation?
Travelers are generally able to look up international airfares on Expedia up to a year in advance of departure. Booking at the last minute? With a stroke of luck, it's still possible to purchase a cheaper ticket only weeks before your journey.
What does an Expedia Downtown South San Francisco travel package include?
With Expedia, you can choose a combination of hotels, flights and car rentals to build your perfect Downtown South San Francisco travel package. Once you've made your booking, you can add on all the fun stuff like activities and tours. Don't forget, the more you bundle, the more cash you'll save!
What should I know before booking a Downtown South San Francisco travel package?
When you book your hotels, flights and car rentals together, you'll land great discounts. Whether you're organizing an outdoor getaway in a chalet or prefer to stay in a ritzy city hotel, Expedia can help make it happen.
Can I choose my airline with a Downtown South San Francisco Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to select from all over the world. With all that choice, finding the ideal carrier to whisk you away to Downtown South San Francisco will be a cinch.
If I'm not able to travel, can I cancel my Downtown South San Francisco vacation package?
It's impossible to predict what tomorrow might bring, so it's comforting to know that you can change or cancel your Downtown South San Francisco vacation package. If you booked in the last 24 hours, you may be entitled to a refund. If it's an older booking, your hotel, airline or car rental company may charge a fee. Visit our Customer Service Portal for more information.

Discover the most popular places to visit in Downtown South San Francisco

Golden Gate Bridge illuminated at night with city lights in the background in California, USA

Golden Gate Bridge

4.5/5(7,244 reviews)

Cars trundle across it and ships sail under it, but the best way to experience this iconic bridge is on foot.

Golden Gate Bridge
Pier 39 which includes a city, signage and street scenes

Pier 39

4.5/5(6,817 reviews)

This waterfront attraction offers thrilling rides, innovative street performers and colorful souvenir shops, but it’s the sea lions that win the day.

Pier 39
Moscone Convention Center

Moscone Convention Center

4/5(598 reviews)

During your trip, find out what's happening at Moscone Convention Center, a top convention center in San Francisco. Discover the fascinating museums and notable monuments in this vibrant area.

Moscone Convention Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.