Weather is probably a major factor when you plan your trip to Santa Cruz del Quiché, and keep in mind that cheaper options are usually available when the weather isn't as good. The hottest months are usually March and April with an average temp of 61°F, while the coldest months are January and December with an average of 60°F. The rainiest months in Santa Cruz del Quiché are June, September, May, and August, with each month seeing an average of 19 inches of rainfall.