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Our top choices for Southeast Missouri hotels

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

1. Madison Inn Lodge

Fredericktown

Bawan

₩126,960 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with two beds, a sofa, a small table, and a telephone.

2. Shepherd Mountain Inn

Ironton

Jonathan

₩179,603 total

includes taxes & fees

Nov 16 - Nov 17

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Shanna

₩173,810 total

includes taxes & fees

Nov 29 - Nov 30

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

4. Holiday Inn Express & Suites Farmington by IHG

Farmington

January

₩169,558 total

includes taxes & fees

Dec 13 - Dec 14

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

5. Fort Davidson Hotel

Ironton

richard

₩182,056 total

includes taxes & fees

Nov 14 - Nov 15

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

6. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

₩139,826 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

₩82,955 total

includes taxes & fees

Nov 29 - Nov 30

An indoor swimming pool with a clear view of the outside through large windows.

8. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Alan

₩141,602 total

includes taxes & fees

Nov 20 - Nov 21

A hotel room with two beds, a large wall-mounted picture of a waterfall, a bedside table with a lamp, and a door.

9. Super 8 by Wyndham Farmington

Farmington

Marisa

₩90,749 total

includes taxes & fees

Nov 27 - Nov 28

A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

10. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

₩133,302 total

includes taxes & fees

Nov 29 - Nov 30

A brick building with a sign reading "Mercantile & Hotel".

11. EC Reed's Mercantile and Hotel

Marble Hill

Jan

₩152,614 total

includes taxes & fees

Dec 13 - Dec 14

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

12. Crown Pointe Lodge, BW Signature Collection

Farmington

christopher

₩154,245 total

includes taxes & fees

Nov 27 - Nov 28

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a landscaped entrance area.

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

richard

₩115,316 total

includes taxes & fees

Nov 16 - Nov 17

A Holiday Inn Express & Suites building with a gas station in front.

14. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Megnauth

₩143,591 total

includes taxes & fees

Dec 13 - Dec 14

A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

15. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Julie

₩128,321 total

includes taxes & fees

Nov 23 - Nov 24

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

16. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

₩166,825 total

includes taxes & fees

Nov 19 - Nov 20

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

17. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Melody

₩150,428 total

includes taxes & fees

Nov 24 - Nov 25

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

18. Drury Inn & Suites Hayti Caruthersville

Hayti

Philip

₩148,937 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

19. Super 8 by Wyndham Perryville

Perryville

Matthew

₩101,389 total

includes taxes & fees

Nov 24 - Nov 25

A modern hotel lobby with a reception desk, seating area, and a large rug.

20. Hampton Inn Farmington

Farmington

Charlie

₩158,408 total

includes taxes & fees

Dec 13 - Dec 14

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Vacation Rentals in Southeast Missouri

Aparthotel

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

The Atrium - A Boutique Hotel

Perryville

"Great place to stay"

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A wooden deck with chairs and a small table, surrounded by lush green trees.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A covered outdoor seating area with a hot tub, a chair, and a table, overlooking a cornfield.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

Cottage

A spacious kitchen with wooden cabinets, a stone fireplace, and a dining area with chairs.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

Cottage

A log cabin with a glass door leading to an outdoor patio, a grill, and a table with chairs.

Peaceful 2-cabin Property: 1 Mi to Current River!

Van Buren

"We had the best time. We had plenty of room for our families that were in town for a wedding. The rental had everything we needed."

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Hampton Inn Poplar Bluff

10/10 Excellent

"Breakfast very good!"

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

8/10 Good

"The room was clean and fresh. But I couldn’t say that about the breakfast area. The food was cold, no coffee, the juice machine was gross, the floor was wet and sticky. Kept running out of food. The trash area stunk around the food. Also the elevator floors were always wet and sticky as well."

Lake Wappapello

10/10 Excellent

"This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from the park. We ordered deli sandwiches from here and picked up some icecream. The sandwiches were delicious and the store had pretty much whatever you might need. The checkin process was great with good communication about which cabin to go to, what the door code was etc... We plan to come back for a longer stay so we can have another evening around the firepit and see all of the stars. Great place to stay."