Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from ₩84,478
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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,017 reviews)
The price is ₩138,678
₩159,445 total
includes taxes & fees
Mar 15 - Mar 16

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (524 reviews)
The price is ₩142,087
₩160,279 total
includes taxes & fees
Mar 16 - Mar 17

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (164 reviews)
The price is ₩149,243
₩168,367 total
includes taxes & fees
Mar 15 - Mar 16

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,019 reviews)
The price is ₩147,531
₩166,436 total
includes taxes & fees
Mar 24 - Mar 25

Days Inn & Suites By Wyndham Festus
Days Inn & Suites By Wyndham FestusFestus
The price is ₩139,431
₩159,439 total
includes taxes & fees
Mar 15 - Mar 16

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,003 reviews)
The price is ₩138,678
₩156,672 total
includes taxes & fees
Mar 15 - Mar 16

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (720 reviews)
The price is ₩124,160
₩134,372 total
includes taxes & fees
Mar 15 - Mar 16

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (876 reviews)
The price is ₩162,301
₩183,359 total
includes taxes & fees
Mar 15 - Mar 16

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (563 reviews)
The price is ₩151,972
₩173,971 total
includes taxes & fees
Apr 5 - Apr 6

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (498 reviews)
The price is ₩137,114
₩155,248 total
includes taxes & fees
Mar 29 - Mar 30

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,009 reviews)
The price is ₩118,022
₩124,779 total
includes taxes & fees
Mar 15 - Mar 16

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (227 reviews)
The price is ₩271,485
₩287,028 total
includes taxes & fees
Mar 17 - Mar 18

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (63 reviews)
The price is ₩149,021
₩168,730 total
includes taxes & fees
Mar 29 - Mar 30

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,007 reviews)
The price is ₩132,777
₩149,790 total
includes taxes & fees
Mar 24 - Mar 25

Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
8.2 out of 10, Very Good, (50 reviews)
The price is ₩95,610
₩109,211 total
includes taxes & fees
Mar 15 - Mar 16

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (56 reviews)
The price is ₩138,693
₩212,737 total
includes taxes & fees
Mar 16 - Mar 17

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (508 reviews)
The price is ₩112,135
₩127,526 total
includes taxes & fees
Mar 11 - Mar 12

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (114 reviews)
The price is ₩140,611
₩160,036 total
includes taxes & fees
Apr 5 - Apr 6

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,007 reviews)
The price is ₩146,071
₩164,789 total
includes taxes & fees
Mar 29 - Mar 30

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (592 reviews)
The price is ₩137,449
₩156,485 total
includes taxes & fees
Mar 16 - Mar 17
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (56 reviews)
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Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO
10/10 Excellent
More cheap stays in Southeast Missouri

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
The price is ₩87,790 per night from Mar 15 to Mar 16
₩87,790
per night
Mar 15 - Mar 16
8/10 Very Good! (1,007 reviews)
Hotels in Southeast Missouri with star-rating

4 Star Hotels
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