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Find hotels in Southeast Missouri, MO from ₩82,939
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Our top choices for Southeast Missouri hotels

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,008 reviews)
The price is ₩132,294
₩149,230 total
includes taxes & fees
Jan 21 - Jan 22

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,002 reviews)
The price is ₩122,004
₩128,987 total
includes taxes & fees
Jan 20 - Jan 21

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.2 out of 10, Wonderful, (49 reviews)
The price is ₩148,480
₩168,115 total
includes taxes & fees
Jan 23 - Jan 24

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (472 reviews)
The price is ₩111,994
₩127,365 total
includes taxes & fees
Jan 30 - Jan 31

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (219 reviews)
The price is ₩241,672
₩255,508 total
includes taxes & fees
Jan 18 - Jan 19

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (980 reviews)
The price is ₩154,714
₩174,785 total
includes taxes & fees
Feb 6 - Feb 7

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (491 reviews)
The price is ₩141,571
₩159,712 total
includes taxes & fees
Jan 20 - Jan 21

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (105 reviews)
The price is ₩131,711
₩149,905 total
includes taxes & fees
Jan 27 - Jan 28

Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
8.8 out of 10, Excellent, (714 reviews)
The price is ₩162,097
₩183,155 total
includes taxes & fees
Jan 24 - Jan 25

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.0 out of 10, Wonderful, (1,000 reviews)
The price is ₩102,892
₩117,108 total
includes taxes & fees
Jan 21 - Jan 22

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
7.8 out of 10, Good, (1,000 reviews)
The price is ₩83,796
₩88,383 total
includes taxes & fees
Jan 22 - Jan 23

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,003 reviews)
The price is ₩138,175
₩158,859 total
includes taxes & fees
Jan 25 - Jan 26

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (151 reviews)
The price is ₩129,369
₩145,946 total
includes taxes & fees
Jan 25 - Jan 26

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (551 reviews)
The price is ₩133,779
₩153,144 total
includes taxes & fees
Jan 29 - Jan 30

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (336 reviews)
The price is ₩132,294
₩143,423 total
includes taxes & fees
Jan 18 - Jan 19

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (463 reviews)
The price is ₩147,891
₩167,449 total
includes taxes & fees
Jan 25 - Jan 26

Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
8.0 out of 10, Very Good, (43 reviews)
The price is ₩82,031
₩93,700 total
includes taxes & fees
Jan 27 - Jan 28

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (865 reviews)
The price is ₩152,449
₩172,229 total
includes taxes & fees
Jan 31 - Feb 1

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (798 reviews)
The price is ₩159,607
₩178,720 total
includes taxes & fees
Feb 14 - Feb 15

Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (480 reviews)
The price is ₩184,201
₩208,726 total
includes taxes & fees
Feb 1 - Feb 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cottage

40-acre Poplar Bluff Nature Lovers Paradise!
40-acre Poplar Bluff Nature Lovers Paradise!Poplar Bluff
10.0 out of 10, Exceptional, (3 reviews)
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
More cheap stays in Southeast Missouri

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
The price is ₩83,796 per night from Jan 22 to Jan 23
₩83,796
₩88,383 total
Jan 22 - Jan 23
includes taxes & fees
7.8/10 Good! (1,005 reviews)
Hotels in Southeast Missouri with star-rating

4 Star Hotels
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