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Our top choices for Southeast Missouri hotels

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (605 reviews)
"Beautiful new hotel didn’t disappoint! Rey comfortable beds. Great breakfast and attentive staff keeping things filed for the best guest experience. I would definitely stop there again on my next trip through Perryville!"
United States
Cheryl
The price is ₩155,282
₩177,760 total
includes taxes & fees
Jul 19 - Jul 20
Holiday Inn Express & Suites Perryville by IHG

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"Wonderful room and food offerings were extra thoughtful."
United States
Jonna
The price is ₩153,730
₩173,429 total
includes taxes & fees
Aug 2 - Aug 3
Drury Plaza Hotel Cape Girardeau Conference Center

Perryville RV Resort

Perryville RV Resort
2.0 star property
Perryville
The price is ₩113,433
₩129,852 total
includes taxes & fees
Jul 6 - Jul 7
Perryville RV Resort

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1,004 reviews)
"It was a great stay"
United States
Daisy
The price is ₩94,707
₩103,089 total
includes taxes & fees
Aug 2 - Aug 3
Baymont Inn and Suites by Wyndham Farmington, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place!"
United States
Jennifer
The price is ₩170,642
₩196,194 total
includes taxes & fees
Jul 29 - Jul 30
Drury Inn & Suites Sikeston, MO

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (617 reviews)
"Always a great place to stay in downtown Cape. Easy access to the local hangouts like Speck Pizza on Broadway."
United States
John
The price is ₩175,730
₩198,248 total
includes taxes & fees
Aug 3 - Aug 4
The Riverview

Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.2 out of 10, Good, (403 reviews)
"Owner was very kind. He knew we were running a long trail race the next morning and got up an hour early so he could make coffee and put out breakfast for us at 5:30 am. We were so grateful!"
United States
Julie
The price is ₩89,510
₩97,767 total
includes taxes & fees
Jul 19 - Jul 20
Super 8 by Wyndham Potosi

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (97 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is ₩184,463
₩208,858 total
includes taxes & fees
Jul 5 - Jul 6
Fairfield Inn & Suites by Marriott Sikeston

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (639 reviews)
"Excellent staff and location was nice and quiet "
United States
Colleen
The price is ₩168,581
₩183,499 total
includes taxes & fees
Jul 19 - Jul 20
Crown Pointe Lodge, BW Signature Collection

Madison Inn Lodge

Madison Inn Lodge
2.5 star property
Fredericktown
7.6 out of 10, Good, (304 reviews)
"Rooms were clean! Beds were comfortable, and the staff were very accommodating."
United States
Ashley
The price is ₩134,542
₩146,965 total
includes taxes & fees
Jul 8 - Jul 9
Madison Inn Lodge

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Staff and breakfast were excellent."
United States
James
The price is ₩169,120
₩190,791 total
includes taxes & fees
Jul 30 - Jul 31
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,003 reviews)
"Great hotel"
United States
mason
The price is ₩110,681
₩124,864 total
includes taxes & fees
Jul 26 - Jul 27
Pear Tree Inn Cape Girardeau West

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,002 reviews)
"Clean room and convenient location."
United States
Morgan
The price is ₩121,459
₩136,019 total
includes taxes & fees
Jul 6 - Jul 7
Motel 6 Poplar Bluff, MO

Deerfield Inn & Suites Steele Near Blytheville I 55

Deerfield Inn & Suites Steele Near Blytheville I 55
2.5 star property
Steele
8.0 out of 10, Very Good, (2 reviews)
The price is ₩73,967
₩85,590 total
includes taxes & fees
Jul 6 - Jul 7
Deerfield Inn & Suites Steele Near Blytheville I 55

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"I will definitely be staying here next time I visit SEMO."
United States
Lee
The price is ₩147,580
₩166,491 total
includes taxes & fees
Jul 26 - Jul 27
Drury Inn & Suites Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (792 reviews)
"Beautiful hotel at a very good price."
United States
Sheldon
The price is ₩142,445
₩154,161 total
includes taxes & fees
Jul 6 - Jul 7
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very Good, (660 reviews)
"Will stay here when I return"
United States
Sarah
The price is ₩99,319
₩108,110 total
includes taxes & fees
Jul 19 - Jul 20
Super 8 by Wyndham Farmington

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (525 reviews)
"Great stay!!"
United States
Taylor
The price is ₩192,335
₩217,941 total
includes taxes & fees
Aug 2 - Aug 3
Courtyard by Marriott Cape Girardeau Downtown

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (367 reviews)
"Simple no frills hotel that we've stayed at a few times while traveling."
United States
Monica
The price is ₩153,576
₩166,506 total
includes taxes & fees
Jul 26 - Jul 27
Honeysuckle Inn - Mountain View

Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (317 reviews)
"Breakfast was good and rooms were clean"
United States
Shannon
The price is ₩189,568
₩207,064 total
includes taxes & fees
Jul 22 - Jul 23
Shepherd Mountain Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Walnut Hollow Lake to K Bridge Recreation Area.

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

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