Southeast Missouri Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to ₩234,741 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Find the Best Southeast Missouri Vacation Packages

Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is ₩77,771 per night from Aug 17 to Aug 18
₩77,771
₩88,543 total
Aug 17 - Aug 18
includes taxes & fees
8/10 Very Good! (1,004 reviews)
"Fair prices and nice staff well taken care ofby the Baymont family"

Reviewed on Jul 30, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is ₩146,237 per night from Aug 17 to Aug 18
₩146,237
₩164,977 total
Aug 17 - Aug 18
includes taxes & fees
9.2/10 Wonderful! (374 reviews)
Definitely recommend.
"This is my 2nd stay and each time has been flawless. Parking is convenient, lobby is clean and check in is a breeze. The rooms are spacious, clean and comfortable. I don't stay here for the casino life but that entertainment option is also very convenient. The availability of having Starbucks downstairs ..."

Reviewed on Aug 9, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is ₩141,641 per night from Aug 14 to Aug 15
₩141,641
₩159,792 total
Aug 14 - Aug 15
includes taxes & fees
9.4/10 Exceptional! (1,005 reviews)
"I always like Drurys because you can count on the breakfast and pool and clean rooms."

Reviewed on Aug 7, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
See all 589 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just . Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.