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Our top choices for Southeast Missouri hotels

A motel with a covered entrance, a flag, and a phone number.

1. Madison Inn Lodge

Fredericktown

Bawan

₩123,860 total

includes taxes & fees

Nov 2 - Nov 3

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

2. Shepherd Mountain Inn

Ironton

Jonathan

₩179,661 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

3. Fort Davidson Hotel

Ironton

richard

₩182,142 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

4. Hampton Inn & Suites By Hilton Festus

Festus

Misty

₩173,866 total

includes taxes & fees

Nov 8 - Nov 9

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

5. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

₩146,034 total

includes taxes & fees

Nov 8 - Nov 9

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

6. Super 8 by Wyndham Farmington

Farmington

Marisa

₩90,777 total

includes taxes & fees

Nov 8 - Nov 9

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

7. Holiday Inn Express & Suites Farmington by IHG

Farmington

January

₩171,173 total

includes taxes & fees

Nov 29 - Nov 30

A bathroom with a white vanity, a black-framed mirror, and a lighted vanity mirror.

8. EC Reed's Mercantile and Hotel

Marble Hill

Jan

₩152,664 total

includes taxes & fees

Nov 2 - Nov 3

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

9. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

₩82,983 total

includes taxes & fees

Nov 8 - Nov 9

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

10. Hampton Inn Farmington

Farmington

Charlie

₩152,998 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

11. Drury Inn & Suites Hayti Caruthersville

Hayti

Philip

₩148,986 total

includes taxes & fees

Nov 8 - Nov 9

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

12. Crown Pointe Lodge, BW Signature Collection

Farmington

christopher

₩154,295 total

includes taxes & fees

Nov 19 - Nov 20

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

13. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Ronald

₩128,362 total

includes taxes & fees

Nov 4 - Nov 5

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

14. The Riverview

Cape Girardeau

Renee

₩172,011 total

includes taxes & fees

Nov 2 - Nov 3

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

15. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

₩135,682 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

16. Super 8 by Wyndham Perryville

Perryville

Matthew

₩105,139 total

includes taxes & fees

Nov 8 - Nov 9

A hotel lobby with a reception desk, seating area, and a patterned carpet.

17. Holiday Inn Express & Suites Perryville by IHG

Perryville

allan p.

₩145,072 total

includes taxes & fees

Nov 29 - Nov 30

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

18. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

J

₩115,351 total

includes taxes & fees

Nov 8 - Nov 9

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

19. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

₩152,222 total

includes taxes & fees

Nov 5 - Nov 6

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

20. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

₩134,599 total

includes taxes & fees

Nov 8 - Nov 9

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Vacation Rentals in Southeast Missouri

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A wooden deck with a hot tub, a small table, and a bench.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A log cabin with a glass door leading to an outdoor patio, a grill, and a table with chairs.

Peaceful 2-cabin Property: 1 Mi to Current River!

Van Buren

"We had the best time. We had plenty of room for our families that were in town for a wedding. The rental had everything we needed."

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

See all vacation rentals