Name: Drury Plaza Hotel Cape Girardeau Conference Center
Price range: ₩132,979
Rating: 9.4

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

₩79,205

₩90,175 total

Dec 21 - Dec 22

includes taxes & fees

Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...

7.8/10 Good! (1,003 reviews)

The rooms where clean, the water was hot in the showers. The staff was family oriented and friendly felt like my family was safe.

Reviewed on Dec 7, 2025

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

₩132,979

₩150,002 total

Dec 18 - Dec 19

includes taxes & fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.4/10 Exceptional! (1,000 reviews)

Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife.

Reviewed on Dec 8, 2025

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

₩112,306

₩118,453 total

Dec 15 - Dec 16

includes taxes & fees

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

7.8/10 Good! (1,004 reviews)

Staff was amazing and super nice. Room was very clean.

Reviewed on Dec 11, 2025

See all 620 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

7555 State Hwy Y French Village MO

Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.

9.8/10 Exceptional! (44 reviews)

The cabin was cozy and very peaceful such a good experience

Reviewed on Nov 11, 2025

Sam A Baker State Park

5732 State Hwy Missouri 143 Patterson MO

Stay at this cabin in Patterson. Enjoy free parking, a picnic area, and furnished patios. Popular attraction Sam A. Baker State Park is located nearby.

9.2/10 Wonderful! (5 reviews)

We stayed two nights and we loved it. The property grounds and cabins are well maintained we will be back

Reviewed on Oct 5, 2025

See all properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Check Southeast Missouri hotel availability

Popular places to visit

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Breathtaking view at the dam by the road and some small trails for walking as well!

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Beautiful area. Easy to get up close and not too far off the main road. 🏞 #waterfalls #nature #explore #missouri

Rocky Falls

4.5/5(2 reviews)

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Southeast Missouri State University

4.5/5(76 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Century Casino Caruthersville

3/5(17 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Isle Casino Cape Girardeau

4.5/5(48 reviews)

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.