Southeastern Indiana Vacations

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Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana
The entrance to the Kentucky Science Center with a large circular structure in the foreground.

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

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Find the Best Southeastern Indiana Vacation Packages

Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundableReserve now, pay when you stay
7/10 Good! (3,305 reviews)
"This is a nice hotel, but VERY weirdly laid out. You enter at one end and need COMPLICATED directions to take SEVERAL halls to get to your room in what appears to be another building (but all under one roof). It seemed a long way to drag in a suitcase. The TV cable would go out while I was watching ..."

Reviewed on Aug 6, 2026

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Radisson Hotel Louisville North
Derby Hotel & Suites

Derby Hotel & Suites

2 out of 5
505 K Marriot Dr Clarksville IN
Fully refundable
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Derby Hotel & Suites
Big Splash Adventure Indoor Water Park & Resort

Big Splash Adventure Indoor Water Park & Resort

3.5 out of 5
8505 W State Road 56 French Lick IN
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Big Splash Adventure Indoor Water Park & Resort
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeastern Indiana attractions

A wall of wooden baseball bats organized by size and weight.

Louisville Slugger Museum

9.2/10 (2,299 reviews)
You can spend an afternoon browsing the exhibits at Louisville Slugger Museum during your travels in Louisville. Amble around the area's riverfront or attend a sporting event.
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Frequently asked questions

How much does a Southeastern Indiana vacation package cost?
Our Southeastern Indiana vacation packages, which start from just , are an ideal way to save loads of cash. Pick and choose your preferred flights, hotels and rental cars to create a custom-built escape.
How do I get a cheap travel package to Southeastern Indiana?
If you love landing a bargain, bundle your bookings into a Southeastern Indiana vacation package. Whether you need flights, hotels, activities or rental cars, you can browse and book everything in one place. You'll have loads of choice at your fingertips too. Expedia has over 550 partner airlines and 1,000,000 hotel options throughout the world to choose from. Fly with who you want, stay wherever you like and save your hard-earned money — now that's the ideal escape!
Where should I stay in Southeastern Indiana?
You'll adore Louisville. Well-known attractions, such as Churchill Downs and Muhammad Ali Center, will keep you entertained in this happening city.
What are the top hotels in Southeastern Indiana?
Galt House Hotel Trademark Collection by Wyndham and Radisson Hotel Louisville Jeffersonville know how to make their guests feel at home in Louisville. If you also plan to stay in Jeffersonville - Clarksville, have a look at Radisson Hotel Louisville Jeffersonville and JW Marriott Indianapolis. Both are top picks with travelers.
How far in advance should I book my Southeastern Indiana vacation?
It can be difficult to know when is the perfect time to book your Southeastern Indiana vacation. But usually the earlier you book, the more affordable the prices. In some cases, you can book your flights and hotels up to 12 months prior to your departure date. If you're thinking of a last-minute getaway, no need to fret! There are fabulous deals posted on Expedia every single day.
What does an Expedia Southeastern Indiana travel package include?
Packages include rental cars, flights and hotels, but you can mix and match them to create your perfect Southeastern Indiana vacation. You can also add on fun things like experiences and activities once you've made your booking. You're in the driver's seat! When you bundle your bookings with Expedia, you'll get access to deals you won't find anywhere else.
What should I know before booking a Southeastern Indiana travel package?
Whether it's adventure or relaxation you're craving, a Southeastern Indiana vacation package lets you organize your escape your way. Plus, you'll get access to great discounts just for combining your hotel with your rental car and flights. The more you bundle, the bigger the savings!
Can I choose my airline with a Southeastern Indiana Expedia vacation package?
Expedia has access to more than 550 partner airlines globally, so you definitely can. Just select your preferred carrier and craft your ideal Southeastern Indiana escape.
If I'm not able to travel, can I cancel my Southeastern Indiana vacation package?
Whether it's your hotel, flight or rental car, you can cancel or alter it. Booked your Southeastern Indiana vacation package in the last 24 hours? You may be able to make changes at no cost. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For further information, look up our Customer Service Portal. We'll help you each step of the way.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.