The Best Business Hotels in Southern Minnesota, MN from ₩118,698 in 2026

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Our top choices for Southern Minnesota business-friendly hotels

Deluxe Suite, 1 King Bed, Non Smoking (One-Bedroom) | Desk, blackout drapes, soundproofing, iron/ironing board

Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, soundproofing, iron/ironing board

1. AmericInn by Wyndham Sleepy Eye

Sleepy Eye

James

₩140,487

₩157,872 total

includes taxes & fees

Sep 27 - Sep 28

In-room safe, desk, iron/ironing board (on request), WiFi (free)

2. Microtel Inn & Suites by Wyndham New Ulm

New Ulm

Cathy

₩107,056

₩118,698 total

includes taxes & fees

Sep 23 - Sep 24

3. Best Western Plus New Ulm

New Ulm

Dolly

₩165,265

₩183,237 total

includes taxes & fees

Oct 11 - Oct 12

Minibar (free items), desk, iron/ironing board, cribs (free)

4. Super 8 by Wyndham St. James

Saint James

Jon

₩125,001

₩136,720 total

includes taxes & fees

Oct 4 - Oct 5

Indoor pool, cabanas (surcharge), sun loungers

Buffalo Tower Non-Smoking King Accessible | In-room safe, desk, laptop workspace, iron/ironing board

5. Treasure Island Resort & Casino

Welch

Gina

₩113,542

₩142,050 total

includes taxes & fees

Sep 22 - Sep 23

Premium bedding, desk, iron/ironing board, rollaway beds (surcharge)

6. Comfort Inn Albert Lea at Trails Travel Center

Albert Lea

Nikolai

₩117,765

₩133,862 total

includes taxes & fees

Oct 18 - Oct 19

Suite (Buffalo Bill Suite) | Living area | Flat-screen TV

7. Stone Mill Hotel & Suites

Lanesboro

Jenifer

₩145,835

₩156,599 total

includes taxes & fees

Oct 18 - Oct 19

8. Country Inn & Suites by Radisson, Albert Lea - Austin

Albert Lea

Moss

₩122,779

₩136,131 total

includes taxes & fees

Oct 11 - Oct 12

View all properties

Top Southern Minnesota Hotel Reviews

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"Wonderful stay, our kids loved the pool, water slide and hot tub!"

Brentwood Inn & Suites

10/10 Excellent

"Parking is free which is a wonderful amenity and we always are so grateful for the easy access to the pedestrian subway at Mayo Clinic."

AmericInn by Wyndham Mankato Event Center

10/10 Excellent

"Easy to drive up to and park...Very friendly staff..."

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"Was there for a surgery at the Mayo and they were so helpful and accommodating. Very grateful for the facility and the staff"

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Could have stayed one more day, but the food was so gross, it dragged everything else down. Biscuits had green mold and white fuzz growing on them. Coffee was terrible all three days I tried to drink it. Too many grounds were used, by as much as 30-40% guessing on how black and syrupy it was (probably from sitting too long). Hot tub and kiddie pool were not working."

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10/10 Excellent

"Yes I would recommend this Hotel"

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"There was a very large (by the sound of his bark) dog just down the hall from us. He had been barking for some time before we called the front desk about it. We were told that it is a dog friendly hotel and nothing they could do and she was very short with us. It took about an hour and the poor dog stopped barking. We understand that people are there because someone they love is sick. We also know that pets are family. If it was my dog, I would have wanted to know. And she didn't need to make us feel bad...."

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Everything was great. My only feedback is the black out curtains were an inch short from blocking light and the shower pressure was fine to get the job done but not excellent."

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Clean. Safe. Warm shower. Nice bed."

Frequently asked questions

How much do business-friendly hotels in Southern Minnesota cost?

Prepare to pay between ₩118,698 and ₩183,237 per night for business-friendly hotels in Southern Minnesota. Terrific deals on stays that cater to corporate travelers are just a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the best business-friendly hotels in Southern Minnesota?

That depends on your destination in Southern Minnesota. Many business travelers to Rochester like staying at Hilton Rochester Mayo Clinic Area. This 3.5-stars property comes with pool sun loungers and a spa. Home2 Suites by Hilton Rochester Mayo Clinic Area is another excellent option if you're attending a conference or working remotely in Rochester. Private winery tours and pool sun loungers are among the useful amenities at this 3-stars getaway. You can choose from multiple business-friendly hotels in Southern Minnesota that have a total average guest review rating of 8.4.

How many business-friendly hotels are there in Southern Minnesota?

When work takes you on the road in Southern Minnesota, you'll have 126 business-friendly hotels to select from.

What are the best cheap business-friendly hotels in Southern Minnesota?

Keep your accountant happy with our business-friendly hotels in Southern Minnesota that start at only ₩118,698 per night. An economical option in Rochester is Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys. Corporate travelers recommend it for its many amenities, such as a tennis court and a swimming pool. If you're headed to Mankato, check out Fairfield Inn & Suites Mankato. A swimming pool and pillow top mattresses are among the conveniences that make it easy to both work and feel at home here. There are tons of fabulous and free attractions around Southern Minnesota. If you have a meeting or conference in Rochester, try to find time in your schedule for Cascade Lake Beach. You can also see the sights without spending your dollars in Mankato. Minneopa State Park is one of the best free things to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the top business-friendly motels in Southern Minnesota?

Expedia's business-friendly motels in Southern Minnesota come with amenities that let you mix work and play. One of our best options is Med City Inn & Suites - Mayo Clinic Area in Rochester. Located around 2 kilometers west of the downtown area, pool sun loungers and a swimming pool are the start of its many conveniences. Another stay that caters to corporate travelers is Baymont by Wyndham Rochester Mayo Clinic Area. It's approximately 2 kilometers south of central Rochester and includes a swimming pool, WiFi and more.Rochester offers a wide range of terrific attractions. Visit Mayowood Mansion and Rochester Civic Theater if you find yourself with some free time.

Are there any family-friendly hotels in Southern Minnesota that are also business friendly?

Certainly. You'll find some wonderful family-friendly hotels that are also business friendly in Southern Minnesota. If you're traveling to Rochester, check out Comfort Inn & Suites West - Medical Center. It comes with amenities such as pillow top mattresses and housekeeping services and has a 3-stars rating. Another property worth considering is DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area. This 4-stars stay in Rochester is ideal for both leisure and business travelers and offers a playground, a sauna and plenty more. Rochester has tons of family-friendly attractions when you're ready to see the sights. Mayowood Mansion and Minnesota Children's Museum promise fun for the whole crew.

Are there any 5-star business-friendly hotels in Southern Minnesota?

While there aren't any 5-star business-friendly hotels in Southern Minnesota, there are still stylish properties to choose from. Heading to Rochester for work? DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area is a popular option that has everything you need and more when you're away on business. Amenities at this 4-star property include designer toiletries and a sauna. The Towers At Kahler Grand Hotel is another recommendation that caters to corporate guests in Rochester. Also with a 4-star rating and offering designer toiletries and concierge services, it'll feel like your home away from home.

Why book your business-friendly hotel in Southern Minnesota with Expedia?

Here at Expedia, our top task is to help you find an ideal stay at the right price. From fancy, corporate-friendly retreats to affordable hotels loaded with conveniences, you'll have your next work trip booked in just a few clicks.

How can I find cheap business-friendly hotels in Southern Minnesota?

Click on the "business friendly" filter, located under the "traveler experience" heading, to find cheap business-friendly hotels in Southern Minnesota. Then fine-tune your search by your per-night budget. Staying in a less popular neighborhood is another easy way to save.

What is there to do in Southern Minnesota near my business-friendly hotel?

Whether you're into shopping, sightseeing, relaxation or adventure, Southern Minnesota offers it all, and then some! The fabulous city of Rochester is home to lots of things to do and see, including Rochester Civic Theater, Minnesota Children's Museum and Cascade Lake Beach. If you're planning a business trip to Mankato, Mount Kato Ski Area, WOW Zone Family Entertainment Center and Betsy & Tacy's House Tours & Gift Shop have to be on your itinerary.

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Check availability on Southern Minnesota Business Hotels

Our top choices for Southern Minnesota business-friendly hotels

1. AmericInn by Wyndham Sleepy Eye

2. Microtel Inn & Suites by Wyndham New Ulm

3. Best Western Plus New Ulm

4. Super 8 by Wyndham St. James

5. Treasure Island Resort & Casino

6. Comfort Inn Albert Lea at Trails Travel Center

7. Stone Mill Hotel & Suites

8. Country Inn & Suites by Radisson, Albert Lea - Austin

9. Comfort Inn & Suites Rochester South Mayo Clinic

10. AmericInn by Wyndham Jackson

Top Southern Minnesota Hotel Reviews

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Brentwood Inn & Suites

AmericInn by Wyndham Mankato Event Center

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Med City Inn & Suites - Mayo Clinic Area

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Kahler Inn and Suites - Mayo Clinic Area

Hotel Indigo Rochester – Mayo Clinic Area by IHG

AmericInn by Wyndham Rochester Near Mayo Clinic

Frequently asked questions

Explore a world of travel with Expedia

Find Business Hotels in Southern Minnesota, MN

Change your mind

Treat yourself

Be picky

Check availability on Southern Minnesota Business Hotels

Our top choices for Southern Minnesota business-friendly hotels

1. AmericInn by Wyndham Sleepy Eye

2. Microtel Inn & Suites by Wyndham New Ulm

3. Best Western Plus New Ulm

4. Super 8 by Wyndham St. James

5. Treasure Island Resort & Casino

6. Comfort Inn Albert Lea at Trails Travel Center

7. Stone Mill Hotel & Suites

8. Country Inn & Suites by Radisson, Albert Lea - Austin

9. Comfort Inn & Suites Rochester South Mayo Clinic

10. AmericInn by Wyndham Jackson

Top Southern Minnesota Hotel Reviews

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Brentwood Inn & Suites

AmericInn by Wyndham Mankato Event Center

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Med City Inn & Suites - Mayo Clinic Area

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Kahler Inn and Suites - Mayo Clinic Area

Hotel Indigo Rochester – Mayo Clinic Area by IHG

AmericInn by Wyndham Rochester Near Mayo Clinic

Frequently asked questions

Explore a world of travel with Expedia