Our top choices for Upstate South Carolina hotels

Carolina Inn Anderson Clemson Area

Anderson

Trevor

₩91,177 total

includes taxes & fees

Jun 4 - Jun 5

Quality Inn Seneca Clemson Area US-123

Downtown

Cheryl

₩156,323 total

includes taxes & fees

Jun 3 - Jun 4

Hampton Inn Gaffney

Gaffney

Theresa

₩131,546 total

includes taxes & fees

Jun 14 - Jun 15

Best Western Plus Clemson Hotel & Conference Center

Clemson

Janis

₩181,774 total

includes taxes & fees

Jun 17 - Jun 18

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Katlynn

₩404,494 total

includes taxes & fees

Jun 1 - Jun 2

Lakeside Lodge Clemson

Seneca

Lynzee

₩202,083 total

includes taxes & fees

Jun 1 - Jun 2

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Sarah

₩212,366 total

includes taxes & fees

Jun 4 - Jun 5

Single Room, 1 King Bed, Non Smoking | Desk, laptop workspace, free WiFi

Deluxe Inn

Mauldin

₩103,498 total

includes taxes & fees

May 30 - May 31

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

₩131,860 total

includes taxes & fees

Jun 14 - Jun 15

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

₩194,265 total

includes taxes & fees

Jun 4 - Jun 5

Tru by Hilton Seneca Clemson

Seneca

James

₩184,325 total

includes taxes & fees

Jun 15 - Jun 16

Urban Boutique Hotel, BW Signature Collection

Greenville

William

₩110,861 total

includes taxes & fees

May 31 - Jun 1

Hampton Inn Greer Greenville, SC

Greer

Alberto

₩192,331 total

includes taxes & fees

Jun 14 - Jun 15

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Charles

₩149,498 total

includes taxes & fees

May 31 - Jun 1

Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix

Clemson Memorabilia House

Clemson

Ashley

₩371,339 total

includes taxes & fees

Jun 9 - Jun 10

Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

₩115,909 total

includes taxes & fees

May 31 - Jun 1

Microtel Inn & Suites by Wyndham Anderson/Clemson

Anderson

Sharon

₩132,471 total

includes taxes & fees

Jun 12 - Jun 13

Hampton Inn & Suites Seneca-Clemson Area

Seneca

Daren

₩180,136 total

includes taxes & fees

Jun 18 - Jun 19

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Gina

₩182,354 total

includes taxes & fees

Jun 5 - Jun 6

The Shepherd Hotel Downtown Clemson

Clemson

Jennifer

₩246,543 total

includes taxes & fees

May 31 - Jun 1

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Vacation Rentals in Upstate South Carolina

Cottage

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"The place was great! The location is very quiet and no problem with parking. Love the bed super comfortable. The staff was very nice we had a great time."

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great spot"

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

Clemson University

4.8/5 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Drury Inn & Suites Greenville

10/10 Excellent

"Stayed three nights, staff was great room was clean."

Hilton Greenville

8/10 Good

"Tv wasn’t connected to wifi so couldn’t use it staff offered suggestions that weren’t equal to what we paid for which isn’t their fault just didn’t want to switch rooms after long travel besides from that room was tidy and clean staff was nice the bathroom fixtures and room ceiling are coming apart"

Embassy Suites Greenville Golf Resort & Conference Center

8/10 Good

"Overall this hotel is nice. We liked the things available at the hotel to do- cornhole, connect 4, dining, firepit, pools….. The indoor pool was down our whole time- it was raining our whole trip so this was something we were looking forward to. The bed was not that comfortable. There was mis communication- we ended up having to pay $100+ security deposit when we arrived although we thought we had paid for everything prior during booking. I wish they would have just done that at booking and then refunded later. Not everything in the room is free (but it’s labeled) $7 for water ! So if you have kids just make sure they don’t open it. All staff were helpful and kind! This was a nice hotel to rest for the night but I don’t think we will go out of our way to stay again."