Our top choices for Upstate South Carolina hotels

Carolina Inn Anderson Clemson Area

Anderson

Trevor

₩91,847 total

includes taxes & fees

Jun 2 - Jun 3

Quality Inn Seneca Clemson Area US-123

Downtown

Cheryl

₩149,464 total

includes taxes & fees

Jun 21 - Jun 22

Hampton Inn Gaffney

Gaffney

Theresa

₩135,131 total

includes taxes & fees

Jun 14 - Jun 15

Best Western Plus Clemson Hotel & Conference Center

Clemson

Greg

₩183,109 total

includes taxes & fees

Jun 14 - Jun 15

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Katlynn

₩407,470 total

includes taxes & fees

Jun 1 - Jun 2

Lakeside Lodge Clemson

Seneca

Lynzee

₩203,570 total

includes taxes & fees

Jun 2 - Jun 3

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Sarah

₩213,931 total

includes taxes & fees

Jun 4 - Jun 5

Single Room, 1 King Bed, Non Smoking | Desk, laptop workspace, free WiFi

Deluxe Inn

Mauldin

₩104,260 total

includes taxes & fees

Jun 1 - Jun 2

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

₩132,831 total

includes taxes & fees

Jun 14 - Jun 15

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

₩192,714 total

includes taxes & fees

Jun 14 - Jun 15

Tru by Hilton Seneca Clemson

Seneca

Jason

₩185,681 total

includes taxes & fees

Jun 15 - Jun 16

Urban Boutique Hotel, BW Signature Collection

Greenville

Kelleylynn

₩116,490 total

includes taxes & fees

Jun 3 - Jun 4

Hampton Inn Greer Greenville, SC

Greer

Alberto

₩193,751 total

includes taxes & fees

Jun 7 - Jun 8

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Charles

₩135,554 total

includes taxes & fees

Jun 14 - Jun 15

Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix

Clemson Memorabilia House

Clemson

Ashley

₩357,373 total

includes taxes & fees

Jun 1 - Jun 2

Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

₩122,389 total

includes taxes & fees

Jun 14 - Jun 15

Microtel Inn & Suites by Wyndham Anderson/Clemson

Anderson

atlantis

₩136,270 total

includes taxes & fees

Jun 19 - Jun 20

Hampton Inn & Suites Seneca-Clemson Area

Seneca

Daren

₩181,439 total

includes taxes & fees

Jun 18 - Jun 19

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Gina

₩183,696 total

includes taxes & fees

Jun 7 - Jun 8

The Shepherd Hotel Downtown Clemson

Clemson

Jennifer

₩248,356 total

includes taxes & fees

Jun 2 - Jun 3

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Stay near popular Upstate South Carolina attractions

Clemson University

4.8/5 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

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Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent

"Amazing spot! We loved the hotel. It was super clean and close to everything that we wanted to see in Greenville. It’s great architecture ace interior design in a wonderful spot on the river- it made it an incredibly peaceful place."

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

10/10 Excellent

"We were surprised at the size of the hotel. It was unassuming from the outside. It was updated and we slept well. It was conveniently close to Furman University, shops, sites, downtown Greenville. We had a lovely stay and would come back again."

Best Western Plus Clemson Hotel & Conference Center

2/10 Terrible

"Save your money and stay elsewhere. The air-conditioning in my room was broken upon arrival. I was told to "give it time to cool down," but after sweating it out for three hours, I finally had to demand a new room. Things didn't get better at the gym—the Peloton bike lacked a power cord and was completely useless, and the fitness area was sparse and dirty. The entire property is severely run-down and in desperate need of maintenance. Very disappointed."

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

6/10 Okay

"The rooms were very dated. Like you had to insert the card in the door instead of just swiping. The French doors in the bathroom did not close all the way so there was no privacy while in the bathroom. The carpet in the room needs replacing or removed. There was just an old carpet smell in the room. The towels in the bathroom had hair on them like maybe the cleaning staff didn’t have their hair tied up."

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"We stayed as a family, and overall were pleased with our visit. They have two pools, one indoor and one outdoor. Both pools were simple but nice. Closes at 10pm for kids, and 10-11pm is adult swim only. They have a nice exercise room available 24/7. Breakfast spread was good. There were hot food items, fruit, yogurts, breads, coffee, juice, etc…, as well as make your own omelette. The hotel staff was friendly and helpful to meet all our needs. There are tennis courts and basketball court on site for use. FYI, if booking through a third party you will need to pay for your parking pass upon arrival. Overall, we would stay again."