Our top choices for Upstate South Carolina hotels

Comfort Inn & Suites Greer - Greenville

Greer

Paula

₩149,081 total

includes taxes & fees

May 24 - May 25

Single Room, 1 King Bed, Non Smoking | Desk, laptop workspace, free WiFi

Deluxe Inn

Mauldin

₩115,266 total

includes taxes & fees

May 31 - Jun 1

Hampton Inn Gaffney

Gaffney

Theresa

₩134,171 total

includes taxes & fees

May 31 - Jun 1

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

₩139,769 total

includes taxes & fees

May 31 - Jun 1

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

Greenville

Melissia

₩123,004 total

includes taxes & fees

May 26 - May 27

Microtel Inn & Suites by Wyndham Anderson/Clemson

Anderson

Sharon

₩139,826 total

includes taxes & fees

Jun 2 - Jun 3

Quality Inn Seneca Clemson Area US-123

Downtown

Cheryl

₩156,332 total

includes taxes & fees

Jun 16 - Jun 17

Carolina Inn Anderson Clemson Area

Anderson

Trevor

₩91,388 total

includes taxes & fees

May 25 - May 26

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Charles

₩151,006 total

includes taxes & fees

May 31 - Jun 1

Wingate by Wyndham - Greenville-Airport

Greenville

Derrick

₩131,897 total

includes taxes & fees

Jun 2 - Jun 3

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

₩181,954 total

includes taxes & fees

May 28 - May 29

Best Western Spartanburg Northwest

Spartanburg

Ashvani

₩146,885 total

includes taxes & fees

Jun 4 - Jun 5

Hampton Inn Anderson/ Alliance Business Park

Anderson

osiry

₩190,087 total

includes taxes & fees

Jun 7 - Jun 8

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

JAY

₩158,240 total

includes taxes & fees

May 31 - Jun 1

Urban Boutique Hotel, BW Signature Collection

Greenville

Jane

₩111,980 total

includes taxes & fees

May 24 - May 25

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Faithann

₩159,558 total

includes taxes & fees

Jun 12 - Jun 13

Quality Inn Clinton - Laurens I-26

Clinton

Christine

₩110,146 total

includes taxes & fees

Jun 14 - Jun 15

Comfort Suites At WestGate Mall

Spartanburg

Brandon

₩163,004 total

includes taxes & fees

Jun 4 - Jun 5

Best Western Plus Spartanburg

Spartanburg

Paul

₩154,568 total

includes taxes & fees

Jun 3 - Jun 4

Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

₩117,078 total

includes taxes & fees

May 24 - May 25

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great place, clean and quiet."

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great spot"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Arrived after office closing, getting pack with key was no problem. The gate code was not on packet, had to call emergency number to get it and got quite the attitude with whom answered."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

Cottage

Wooded Cottage - 3 Mi to Clemson University

Clemson

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Stay near popular Upstate South Carolina attractions

Clemson University

4.8/5 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Best Western Plus Clemson Hotel & Conference Center

6/10 Okay

"The lighting throughout the hotel and in the room are so harsh and bright it is hard to relax. Otherwise, it is a clean and convenient hotel with friendly staff."

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

4/10 Poor

"I wrote an email and it seems like not much will become of it. So I stayed here for 2 days. The staff was fine. I like the location and the breakfast was good and many options. Unfortunately I had some issues with the room. My door stuck to open on the first night. The T.V. remote did not work. Some of the lamps did not turn on. The water pressure in the toilet was not strong. Then the next morning one of the elevators were out of order so I had to take the stairs or go on the other side of the hotel to use that elevator. Also the fitness center was closed for maintenance. Lastly, which was the worse is the AC on my last night did not blow cold. It was barley cool. I did not sleep well. This La Quinta needs a remodel and or repairs. Because of those and no email response from customer service, I have to give it low ratings."

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"Embassy Suites will now be our go-to stay while in the area. The staff was super friendly and helpful, and the hotel felt clean and fresh—from the lobby to the room. Little touches, like the personalized welcome message on the TV and the mint chocolates on the side tables, made it feel especially welcoming. We loved relaxing in the atrium by the water feature and enjoying a delicious made-to-order omelet. Our stay was just what we would expect and recommend staying here."

Best Western Plus Greenville I-385 Inn & Suites

10/10 Excellent

"The ladies running the breakfast were the best I’ve ever seen. Better than any high dollar hotel. Front desk was great as well. It was a busy graduation weekend and they were gracious and polite. This is where we will stay again in the future"