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Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1002)
"Great location, spotless rooms, attentive and friendly staff, great value."
United States
David
The price is ₩531,601
₩598,052 total
includes taxes & fees
Dec 22 - Dec 23
Almond Tree Inn Hotel - Adults Only
Exterior
Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1000)
"Staff awesome, good breakfast great location"
United States
Carin helen
The price is ₩531,601
₩598,052 total
includes taxes & fees
Dec 22 - Dec 23
Orchid Key Inn - Adults Only
Carriage House | Terrace/patio
The Gardens Hotel

The Gardens Hotel

The Gardens Hotel
4.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1001)
"Amazing hotel, the perfect Key West vibe. Clean rooms, delicious breakfast. We will come back again"
United States
Isis
The price is ₩663,208
₩746,108 total
includes taxes & fees
Dec 22 - Dec 23
The Gardens Hotel
King Room D | Balcony
Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (883)
"The staff was really nice"
United States
doug
The price is ₩486,094
₩546,856 total
includes taxes & fees
Dec 22 - Dec 23
Simonton Court Historic Inn & Cottages
Outdoor pool, sun loungers
The Conch House Heritage Inn

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (145)
"Fantastic location "
United States
ANDREW
The price is ₩507,429
₩570,858 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Conch House Heritage Inn
Exterior
The Marquesa Hotel

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1000)
"Perfect place to stay. "
United States
Paulette
The price is ₩781,592
₩962,407 total
includes taxes & fees
Dec 22 - Dec 23
The Marquesa Hotel
Deluxe Suite, 1 King Bed, Private Pool | View from room
H2O Suites - Adults Only

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (581)
"Great place!!"
United States
Joel
The price is ₩648,618
₩829,426 total
includes taxes & fees
Dec 23 - Dec 24
H2O Suites - Adults Only
Signature Apartment, 1 Bedroom, Kitchen, Poolside (Room 17) | Terrace/patio
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
3.5 star property
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (134)
"We absolutely loved finding this gem to stay on our first visit to Key West. Great location, wonderful staff, and excellent room. "
United States
Sammy
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Exterior
Coco Plum Inn

Coco Plum Inn

Coco Plum Inn
3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (467)
"Love the place convenient, clean and really nice"
United States
Matthew
The price is ₩450,782
₩507,148 total
includes taxes & fees
Dec 22 - Dec 23
Coco Plum Inn
11 Gecko's Garden - Adults Only | Premium bedding, pillowtop beds, individually decorated
Tropical Inn

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (363)
"The place was excellent and the service amazing "
United States
Janae
The price is ₩362,635
₩444,901 total
includes taxes & fees
Dec 23 - Dec 24
Tropical Inn
Garden
Douglas House

Douglas House

Douglas House
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (229)
"We were very pleased with everything and great location."
United States
Lynn
The price is ₩326,650
₩404,230 total
includes taxes & fees
Dec 23 - Dec 24
Douglas House
Fountain
Island City House Hotel

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1001)
"Excellent stay"
United States
Emily Barbara
The price is ₩505,301
₩568,463 total
includes taxes & fees
Dec 23 - Dec 24
Island City House Hotel
Courtyard
Santa Maria Suites

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1000)
"Awesome place we loved it"
United States
Josh
The price is ₩781,592
₩979,022 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Santa Maria Suites
Exterior
The Grand Guesthouse

The Grand Guesthouse

The Grand Guesthouse
2.5 star property
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1000)
"Great stay"
United States
Ginger
The price is ₩273,829
₩344,994 total
includes taxes & fees
Dec 22 - Dec 23
The Grand Guesthouse
Premium bedding, iron/ironing board, free WiFi, bed sheets
Weatherstation Inn

Weatherstation Inn

Weatherstation Inn
2.5 star property
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (995)
"Wonderful property safe neighborhood convenient to all activities would stay here again."
United States
William
The price is ₩441,770
₩496,991 total
includes taxes & fees
Dec 22 - Dec 23
Weatherstation Inn
View from property
Duval House

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1001)
"I loved this place the location was absolutely perfect "
United States
Frank
The price is ₩294,021
₩362,539 total
includes taxes & fees
Dec 23 - Dec 24
Duval House
Front of property
L'Habitation Guest House

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (924)
"A great no hassle stay."
United States
Gary
The price is ₩259,181
₩291,582 total
includes taxes & fees
Dec 23 - Dec 24
L'Habitation Guest House
Outdoor pool, pool umbrellas, sun loungers
Marrero's Guest Mansion

Marrero's Guest Mansion

Marrero's Guest Mansion
3.5 star property
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (335)
"Location very good Staff friendly Pool not well maintained Breakfast and happy hour lacking compared to others"
United States
Scott
The price is ₩480,184
₩540,214 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Marrero's Guest Mansion
3 outdoor pools, a heated pool, sun loungers
Ambrosia Key West

Ambrosia Key West

Ambrosia Key West
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1001)
"Great location and clean room. Pool was relaxing; breakfast was good!"
United States
Jennifer
The price is ₩375,505
₩422,444 total
includes taxes & fees
Dec 24 - Dec 25
Ambrosia Key West
Outdoor pool, open 8:00 AM to 10:00 PM, sun loungers
Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
3.5 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (411)
"The cottage was perfect, centrally located and a wonderful place to stay!"
United States
Claudia
The price is ₩536,082
₩677,897 total
includes taxes & fees
Dec 23 - Dec 24
Ella's Cottages - Key West Historic Inns
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Florida Keys National Marine Sanctuary Hotel Reviews

Pegasus International Hotel

Pegasus International Hotel

10/10 Excellent
"Ja"
Chris 1-night trip
Posted 13 hours ago
Pegasus International Hotel

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center which includes interior views

Florida Keys Eco - Discovery Center

4.3/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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Fort Zachary Taylor Park, Key West. State Park in Florida, USA., Shutterstock ID 761867707, Purchase Order: SP-1891 Wave 0, Client/Licensee: Hotels.com

Fort Zachary Taylor Historic State Park

4.4/5 (1,160 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1604 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and private balconies. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I be able to find near Florida Keys National Marine Sanctuary?
Expedia has 1604 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.
Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?
To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Key West Film Society, Red Barn Theater, and Waterfront Playhouse if you're interested in local theater.