South Main, TX
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
Angela at the front desk was the only bright spot in our stay!! The parking attendants were rude and we had a reservation!! It was like we were trying to take advantage of the parking. I showed them our reservation on Expedia and they were still rude. The front desk had two people checking in during ...
Reviewed on Mar 22, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Everything was good. No complaints
Reviewed on Mar 23, 2026
Hotel Zaza Houston Museum District
Great vibe
Reviewed on Mar 22, 2026
The Royal Sonesta Houston Galleria
Comfortable and conveniently located
Reviewed on Mar 22, 2026
Club Quarters Hotel Downtown, Houston
I was expecting it to be much better given the (previous) reviews but it was just average/ok!
Reviewed on Mar 22, 2026
Blossom Hotel Houston, Curio Collection by Hilton
The room was nice and clean staff super friendly
Reviewed on Mar 22, 2026
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
