South Central Houston, TX

Houston

The Houston Garden Center with a central fountain, surrounded by vibrant flower beds and a well-maintained garden.
A large historic building with a red roof and arched windows, surrounded by a well-maintained garden and a clear blue sky.
A city skyline at night with illuminated skyscrapers and a large brick plaza in the foreground.
An aerial view of a park with a large dome structure, surrounded by trees and a body of water.
A fountain in front of a building with multiple water jets.

Stay near popular South Central Houston attractions

A large historic building with a red roof and arched windows, surrounded by a well-maintained garden and a clear blue sky.

Rice University

8.6/10 (1,772 reviews)
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed theater scene and fascinating museums.
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South Central Houston Hotel Deals

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
The price is ₩130,688 per night from Nov 29 to Nov 30
₩130,688
₩154,451 total
Nov 29 - Nov 30
includes taxes & fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our ...
Hilton Houston Plaza/Medical Center
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
The price is ₩257,268 per night from Nov 23 to Nov 24
₩257,268
₩364,218 total
Nov 23 - Nov 24
includes taxes & fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,017 reviews)
"The hotel staff are friendly and helpful. Especially the car service people. The location is perfect if you are visiting Rice University. I have now stayed at this hotel twice. The only issue is the hotel is a a little tired. One elevator was not working. Water leaking on bathroom floor. Iron board ..."

Reviewed on Nov 13, 2026

Hotel Zaza Houston Museum District
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
The price is ₩150,385 per night from Nov 21 to Nov 22
₩150,385
₩187,184 total
Nov 21 - Nov 22
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
The Westin Houston Medical Center/Museum District
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
The price is ₩203,197 per night from Nov 22 to Nov 23
₩203,197
₩264,476 total
Nov 22 - Nov 23
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
InterContinental Houston by IHG
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
The price is ₩90,001 per night from Dec 13 to Dec 14
₩90,001
₩105,670 total
Dec 13 - Dec 14
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
The price is ₩203,397 per night from Nov 22 to Nov 23
₩203,397
₩280,782 total
Nov 22 - Nov 23
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9/10 Wonderful! (1,000 reviews)
"Location was best"

Reviewed on Nov 8, 2026

Houston Marriott Medical Center/Museum District
See all 1,294 properties in South Central Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

South Central Houston, TX