South Central Houston, TX

Houston

A water feature with multiple tiers and a circular viewing platform at the top.
A city skyline at night with illuminated skyscrapers and a large brick plaza in the foreground.
A train on tracks with graffiti on a nearby building.
A park with a gazebo, a fountain, and tall buildings in the background.
A water feature with a cascading waterfall, a grassy hill, and a tall building in the background.

Stay near popular South Central Houston attractions

A large historic building with a red roof and arched windows, surrounded by a well-maintained garden and a clear blue sky.

Rice University

8.6/10 (1,772 reviews)
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed theater scene and lively festivals.
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South Central Houston Hotel Deals

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
The price is ₩328,215 per night from Aug 14 to Aug 15
₩328,215
₩439,996 total
Aug 14 - Aug 15
includes taxes & fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Hotel Zaza Houston Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
The price is ₩125,498 per night from Aug 30 to Aug 31
₩125,498
₩148,476 total
Aug 30 - Aug 31
includes taxes & fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our ...
Hilton Houston Plaza/Medical Center
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
The price is ₩203,566 per night from Sep 6 to Sep 7
₩203,566
₩253,377 total
Sep 6 - Sep 7
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
The Westin Houston Medical Center/Museum District
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
The price is ₩233,680 per night from Aug 16 to Aug 17
₩233,680
₩301,747 total
Aug 16 - Aug 17
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
InterContinental Houston by IHG
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
The price is ₩191,521 per night from Aug 21 to Aug 22
₩191,521
₩269,013 total
Aug 21 - Aug 22
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9/10 Wonderful! (1,000 reviews)
"Always my go to for stays during medical issues with parents."

Reviewed on Aug 11, 2026

Houston Marriott Medical Center/Museum District
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
The price is ₩173,141 per night from Aug 21 to Aug 22
₩173,141
₩202,574 total
Aug 21 - Aug 22
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
DoubleTree by Hilton Houston Medical Center Hotel & Suites
See all 1,251 properties in South Central Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.

South Central Houston, TX