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Find hotels in South Central Houston, Houston from ₩92,574

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Our top choices for South Central Houston hotels

Sundeck
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very Good, (1739)
"Loved the room, clean, friendly staff. Would reccomend :)"
United States
Rolando
The price is ₩129,527
₩153,246 total
includes taxes & fees
Dec 29 - Dec 30
Hilton Houston Plaza/Medical Center
Exterior
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
7.8 out of 10, Good, (34)
"Clean room and amenities. The grounds are clean as well. There is free parking available for one car."
United States
Erika
The price is ₩125,278
₩146,583 total
includes taxes & fees
Dec 12 - Dec 13
Downtowner Inns - Houston Downtown
Daily buffet breakfast for a fee
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very Good, (471)
"Solid hotel and amenities"
United States
Kenneth
The price is ₩127,842
₩149,574 total
includes taxes & fees
Dec 22 - Dec 23
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Lobby
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1003)
"Comfortable bed, very clean, very good food, quite, friendly stuff and hotel shuttle works easy."
United States
Elena
The price is ₩209,676
₩291,986 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Houston Marriott Medical Center/Museum District
Reception
InterContinental Houston by IHG

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1002)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is ₩209,529
₩274,454 total
includes taxes & fees
Dec 22 - Dec 23
InterContinental Houston by IHG
Outdoor pool, free cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1003)
"Clean room close to food, coffee and hospitals. "
United States
Patrick
The price is ₩200,642
₩249,738 total
includes taxes & fees
Dec 19 - Dec 20
The Westin Houston Medical Center/Museum District
Desk, free WiFi, bed sheets, alarm clocks
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very Good, (1001)
"Nice hotel"
United States
Robert Jeanmard
The price is ₩123,300
₩144,261 total
includes taxes & fees
Dec 22 - Dec 23
Americas Best Value Inn Medical Center Downtown
House | 3 bedrooms, Internet
Luxurious 3 Bed3 Bath Near Downtown Houston

Luxurious 3 Bed3 Bath Near Downtown Houston

Luxurious 3 Bed3 Bath Near Downtown Houston
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1)
"This was made for a perfect family vacation… super clean kid friendly with an awesome view of Houston for the adults on rooftop "
United States
Ebony
The price is ₩128,653
₩483,791 total
includes taxes & fees
Dec 15 - Dec 16
Luxurious 3 Bed3 Bath Near Downtown Houston
Premium bedding, pillowtop beds, minibar, in-room safe
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1843)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District
Double Room, 1 Queen Bed with Sofa bed | In-room safe, individually decorated, individually furnished, desk
Wanderstay Boutique Hotel

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (57)
"Great location will stay again "
United States
Jason
The price is ₩164,840
₩192,870 total
includes taxes & fees
Dec 19 - Dec 20
Wanderstay Boutique Hotel
Premium bedding, down comforters, pillowtop beds, in-room safe
Hilton University of Houston

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (885)
"Nice place to stay"
United States
Alexandra
The price is ₩215,799
₩252,485 total
includes taxes & fees
Dec 20 - Dec 21
Hilton University of Houston
Exterior
La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (542)
"great neighborhood, friendly staff, and delicious breakfast"
United States
Anna
The price is ₩262,278
₩306,865 total
includes taxes & fees
Dec 16 - Dec 17
La Maison in Midtown an urban B&B
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (201)
" Beautiful relaxing love this place best I seen thank you"
United States
James
The price is ₩303,305
₩376,846 total
includes taxes & fees
Dec 22 - Dec 23
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
House, 3 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker, electric kettle
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
3.0 star property
South Central Houston
The price is ₩312,580
₩874,075 total
includes taxes & fees
Dec 14 - Dec 15
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
Comfort Townhome | Private kitchen | Full-size fridge, microwave, oven, dishwasher
Modern Cozy Home with King Bed

Modern Cozy Home with King Bed

Modern Cozy Home with King Bed
3.5 star property
South Central Houston
9.4 out of 10, Exceptional, (22)
"Very spacious and close to just about everything. The view is amazing too"
United States
Brenden
The price is ₩197,807
₩509,830 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Modern Cozy Home with King Bed
Standard Room, 1 King Bed | 1 bedroom, premium bedding, blackout drapes, free WiFi
Southmore Boulevard Motel

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (226)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is ₩79,123
₩92,574 total
includes taxes & fees
Dec 21 - Dec 22
Southmore Boulevard Motel
Lobby
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1000)
"Room was very large…"
United States
Veronica
The price is ₩110,757
₩130,025 total
includes taxes & fees
Dec 14 - Dec 15
Extended Stay America Suites Houston Med Ctr Braeswood Bl
House | 6 bedrooms, Internet
Perfect Houston Group Stay for 12 With 6 Beds 6 Baths

Perfect Houston Group Stay for 12 With 6 Beds 6 Baths

Perfect Houston Group Stay for 12 With 6 Beds 6 Baths
2.0 star property
South Central Houston
The price is ₩446,998
₩1,189,520 total
includes taxes & fees
Dec 16 - Dec 17
Perfect Houston Group Stay for 12 With 6 Beds 6 Baths
Interior
Wanderstay Houston Hostel

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.4 out of 10, Very Good, (188)
"This is an amazing place to stay."
United States
Darius
The price is ₩84,134
₩98,449 total
includes taxes & fees
Dec 12 - Dec 13
Wanderstay Houston Hostel
Apartment | 4 bedrooms, desk, Internet
The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1)
The price is ₩427,199
₩999,720 total
includes taxes & fees
Dec 18 - Dec 19
The Green Haus Luxxe Cabana Rooftop Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Menil Collection which includes art and interior views

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Top South Central Houston Hotel Reviews

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

10/10 Excellent
"yes"
Zoe 1-night trip
Posted 3 days ago
Hilton Houston Plaza/Medical Center

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Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out Midtown Arts and Theater Center Houston and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, La Maison in Midtown an urban B&B is the highest ranked property in South Central Houston. This B&B is a short 4-minute walk from Westheimer Road, and it offers free breakfast and free parking. Other favorite options in the area include Wanderstay Boutique Hotel and MyCrib Houston Hostel.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1150 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and James Turrell's Twilight Epiphany Skyscape. Midtown Arts and Theater Center Houston and Children's Museum of Houston are some other stops to visit in the neighborhood. Toyota Center, Shape Community Center, and Project Row Houses are just a few of the places to visit in and around South Central Houston. H&PE Arena and Eldorado Ballroom are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station.