The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

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Our top choices for Mayo Clinic Scottsdale hotels

A cluster of modern, multi-story buildings with a river in the foreground.

A golf course with a pond, a clubhouse, and a hilly backdrop.

An outdoor patio with a stone wall, wooden pergola, and a cactus.

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

1. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Shelby

₩177,693

₩202,871 total

includes taxes & fees

Oct 25 - Oct 26

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A modern living room with a fireplace, a large flat-screen TV, and comfortable seating.

A hotel courtyard with a paved walkway, palm trees, and a building with multiple balconies and a glass facade.

2. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

Michael

₩119,594

₩136,301 total

includes taxes & fees

Oct 18 - Oct 19

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel room with a sofa, a desk, a chair, a bed, and a door leading to another room.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

A hotel room with a sofa, a TV, a desk, and a chair. There are framed pictures on the wall.

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Paul

₩112,984

₩128,774 total

includes taxes & fees

Oct 25 - Oct 26

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

A multi-story hotel with a central courtyard, parking, and a mountainous backdrop.

A spacious living area with a sofa, chairs, a coffee table, and a TV mounted on the wall.

A bar area with a long counter, multiple stools, and overhead pendant lighting.

4. Hyatt House North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Slyqavious

₩181,406

₩206,749 total

includes taxes & fees

Oct 21 - Oct 22

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A dining area with a large table set for six, surrounded by chairs, with a view of cacti and a stone wall outside.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

A golf course with a mountain backdrop, surrounded by desert vegetation.

5. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

jennifer

₩120,265

₩177,319 total

includes taxes & fees

Oct 19 - Oct 20

A wooden door with a glass panel, a doormat, and a small window above it.

A modern kitchen with white cabinets, a built-in oven, and a large window.

A bedroom with a desk, a bed, a ceiling fan, and a window with blinds.

6. Close to Hiking! Family-friendly Mesa Retreat

13.6 km from Mayo Clinic Scottsdale

₩241,677

₩1,051,295 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern living room with a sectional sofa, orange ottomans, a dining area, and a kitchen with a stone accent wall.

A modern lobby with a seating area, a kitchen, and a reception desk.

A modern kitchen area with a dining table and chairs, a stone accent wall, and various kitchen appliances and storage cabinets.

7. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Damon

₩211,296

₩241,447 total

includes taxes & fees

Nov 1 - Nov 2

A modern infinity pool with a view of mountains and a sunset.

A modern bar area with a unique ceiling design, a bar counter with multiple screens, and a patterned carpet.

A poolside lounge with a view of a hotel building, a TV, and a bar area with a bottle of champagne.

An outdoor seating area with fire pits and lounge chairs, surrounded by trees and a building with illuminated windows in the background.

8. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Jessica

₩274,528

₩351,295 total

includes taxes & fees

Nov 9 - Nov 10

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A reception area with a stone wall, a wooden reception desk, and a modern elevator.

A modern hotel lobby with a fireplace, seating area, kitchen, and a large TV.

9. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

LAURA

₩146,334

₩166,851 total

includes taxes & fees

Oct 25 - Oct 26

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A modern hotel lobby with a bar area, seating, a coffee machine, and a TV.

A bar area with a bar counter, multiple chairs, and a sofa.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

10. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

PATRICK

₩137,367

₩156,558 total

includes taxes & fees

Oct 26 - Oct 27

A landscaped garden with a fountain, palm trees, and a building with a red roof.

A courtyard with palm trees, a fountain, and a bench.

A modern kitchen with a glass dining table, bar stools, and a built-in island with a microwave and oven.

A tranquil pond with a fountain, surrounded by lush greenery and a large building in the background.

11. Westgate Painted Mountain Golf Resort

17.4 km from Mayo Clinic Scottsdale

Tammie

₩134,874

₩154,129 total

includes taxes & fees

Nov 9 - Nov 10

A spacious living area with a kitchen, modern furniture, and a fireplace.

A hotel room with a large bed, a dresser with drawers, a wardrobe, and a wall-mounted TV displaying a pool view.

A spacious lobby with a high ceiling, modern chandeliers, a fire feature, and a large TV screen.

A modern kitchen with blue cabinets, a stainless steel refrigerator, and a white countertop.

12. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

Guadalupe

₩146,349

₩167,093 total

includes taxes & fees

Oct 19 - Oct 20

A hotel room with two beds, a TV, a desk, and a window with a view.

A hotel room with two beds, a desk, a TV, and a balcony with a view.

A modern office space with multiple desks, chairs, and a meeting area.

A modern hotel room with a large window, a desk with a lamp, a microwave, and a chair.

13. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Herlyn

₩109,086

₩124,545 total

includes taxes & fees

Oct 21 - Oct 22

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

A Courtyard by Marriott hotel with a modern design, featuring a covered entrance and stone pillars.

A modern lobby with a central water feature, seating area, and a stone pillar.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and outdoor seating.

14. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

₩208,111

₩237,185 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

A hotel room with two beds, a desk, a sofa, and a TV.

A spacious living area with a sofa, armchairs, and a coffee table. There is a TV mounted on the wall and a balcony with outdoor seating.

A bar area with a long counter, multiple bar stools, and overhead lighting.

15. Hyatt Place Scottsdale - North

14.1 km from Mayo Clinic Scottsdale

Ted

₩194,844

₩222,065 total

includes taxes & fees

Oct 25 - Oct 26

A resort with multiple buildings, a large pool area, and surrounding mountains.

A dining area with a table set for six, overlooking a scenic landscape.

An outdoor wedding reception with round tables set with white chairs, floral centerpieces, and a view of the city in the background.

A dining area with a table and chairs, a view of a cityscape, and decorative wall panels.

16. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Garrett

₩245,503

₩333,989 total

includes taxes & fees

Oct 18 - Oct 19

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

A hotel pool area with multiple lounge chairs, a small pool, and a building with a sign.

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

A modern hotel lobby with a curved reception desk, seating area with sofas and chairs, and a large wall with a 'HOME2' sign.

17. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

₩153,053

₩174,511 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a large bed, a dining table with chairs, a sofa, a television, and a kitchenette.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and palm trees.

A hotel gym with dumbbells on racks, a bench, and a mirror.

A hotel room with a desk, chair, television, lamp, and a framed artwork on the wall.

18. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Melanie

₩140,978

₩160,673 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor patio area with round tables and chairs, a pool in the background, and a covered seating area.

A hotel room with a bed, a desk, a chair, a sofa, a small table, and a TV.

A multi-story hotel with illuminated signage reading "Talking Stick" and "Resort".

A hotel reception area with a large bridge mural, a reception desk, and a snack bar.

19. Staybridge Suites Scottsdale - Talking Stick by IHG

9.7 km from Mayo Clinic Scottsdale

Gentry

₩221,537

₩252,596 total

includes taxes & fees

Oct 26 - Oct 27

A modern hotel lobby with a long bar area, multiple seating options, and large windows offering views of palm trees and a pool.

A modern kitchen with dark wooden cabinets, a white countertop, and a black refrigerator.

A swimming pool with lounge chairs and palm trees, surrounded by a building with multiple windows and a covered patio area.

An outdoor patio area with stone pillars, fire pit seating, and tables.

20. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

Central Scottsdale, 12.3 km from Mayo Clinic Scottsdale

Dana

₩218,158

₩248,635 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Inn at Eagle Mountain	9.0 Wonderful 1,028 reviews	View
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very good 1,088 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	8.8 Excellent 1,871 reviews	View
Hyatt House North Scottsdale	9.6 Exceptional 1,007 reviews	View
Wekopa Casino Resort	9.2 Wonderful 1,000 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

Talking Stick Resort

8/10 Good

"Room was dated bathroom socket didn't work"

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

10/10 Excellent

"Awesome"

Aiden by Best Western Scottsdale North

10/10 Excellent

"This hotel was really nice. I didn't get to utilize the pool or bar as I wanted. While on our visit the hotel was fully booked with teenagers for a sports event. Our room was the only quiet place. I would recommend this place for any stay in Scottsdale."

Inn at Eagle Mountain

10/10 Excellent

"Great place to stay beautiful"

Tru By Hilton Scottsdale Salt River

10/10 Excellent

"Very clean rooms and the staff very polite and friendly,"

Fountain Park Hotel, BW Signature Collection

8/10 Good

"Hotel was conveniently located to the shops at Fountain Hills. Busy street. Room had a slightly musty smell but was clean. Breakfast was offered (coffee, pastries), but was not extensive. Overall, excellent value for the price paid."

Staybridge Suites Scottsdale - Talking Stick by IHG

8/10 Good

"All was clean."

Wekopa Casino Resort

10/10 Excellent

"The hotel staff was very accommodating and helped us check in a little early as we had spa appointments. The beds were comfortable. The room is spacious. The bathroom products have a slight scent that was very pleasing and not overwhelming. There are numerous places to eat - from grab and go to a fine dining restaurant. We had dinner and breakfast in the new Sports Entertainment restaurant, and both meals were very good. This was great for a "staycation" - spa treatments, meal, bingo and gambling. It was raining so we did not try the pool, but it looked inviting."

Hampton Inn & Suites Scottsdale at Talking Stick

10/10 Excellent

"Love it here super clean and friendly. especially the white guy at night he was supper nice and helpful."

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

Find hotels near Mayo Clinic Scottsdale, Phoenix from ₩124,545

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Our top choices for Mayo Clinic Scottsdale hotels

1. Inn at Eagle Mountain

2. Sonesta Select Scottsdale at Mayo Clinic Campus

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

4. Hyatt House North Scottsdale

5. Wekopa Casino Resort

6. Close to Hiking! Family-friendly Mesa Retreat

7. Home2 Suites by Hilton Mesa Longbow, AZ

8. Talking Stick Resort

9. Comfort Suites Scottsdale Talking Stick Entertainment District

10. Aiden by Best Western Scottsdale North

11. Westgate Painted Mountain Golf Resort

12. Fountain Park Hotel, BW Signature Collection

13. Spark by Hilton Fountain Hills Scottsdale

14. Courtyard Scottsdale Salt River

15. Hyatt Place Scottsdale - North

16. ADERO Scottsdale Resort, Autograph Collection

17. Tru By Hilton Scottsdale Salt River

18. Holiday Inn Express Scottsdale North by IHG

19. Staybridge Suites Scottsdale - Talking Stick by IHG

20. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Talking Stick Resort

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Aiden by Best Western Scottsdale North

Inn at Eagle Mountain

Tru By Hilton Scottsdale Salt River

Fountain Park Hotel, BW Signature Collection

Staybridge Suites Scottsdale - Talking Stick by IHG

Wekopa Casino Resort

Hampton Inn & Suites Scottsdale at Talking Stick

Frequently asked questions