The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

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Our top choices for Mayo Clinic Scottsdale hotels

A cluster of modern, multi-story buildings with a river in the foreground.

A dining area with a glass table, wooden chairs, and potted plants.

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

An outdoor patio with a stone wall, wooden pergola, and a cactus.

1. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Andrei

₩226,482

₩258,572 total

includes taxes & fees

Oct 7 - Oct 8

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A breakfast buffet area with various pastries and a sign indicating the price of a cheese danish.

A modern living room with a fireplace, a large flat-screen TV, and comfortable seating.

A hotel courtyard with a paved walkway, palm trees, and a building with multiple balconies and a glass facade.

2. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

Michael

₩144,877

₩165,116 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor dining table set with chairs, string lights, and a sunset view.

A modern living room with a sectional sofa, orange ottomans, a dining area, and a kitchen with a stone accent wall.

A multi-story hotel with a prominent entrance, large windows, and a well-lit facade.

A modern lobby with a seating area, a kitchen, and a reception desk.

3. Home2 Suites by Hilton Mesa Longbow, AZ

14.8 km from Mayo Clinic Scottsdale

Damon

₩211,499

₩241,679 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A modern hotel lobby with a fireplace, seating area, kitchen, and a large TV.

A modern hotel lobby with a central bar area, seating arrangements, and a clean, contemporary design.

4. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

William

₩140,138

₩159,786 total

includes taxes & fees

Oct 11 - Oct 12

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel room with a sofa, a desk, a chair, a bed, and a door leading to another room.

A hotel room with two beds, a desk, a lamp, and a window with curtains.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

5. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Cathleen

₩113,899

₩129,810 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a TV, a desk, and a window with a view.

A pool area with a clear blue pool, lounge chairs, and a multi-story building with balconies.

A modern hotel room with a large window, a desk with a lamp, a microwave, and a chair.

A hotel room with two beds, a desk, a TV, and a balcony with a view.

6. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Peyton

₩104,366

₩119,153 total

includes taxes & fees

Oct 8 - Oct 9

A spacious living area with a kitchen, modern furniture, and a fireplace.

A modern kitchen with blue cabinets, a stainless steel refrigerator, and a white countertop.

A spacious lobby with a high ceiling, modern chandeliers, a fire feature, and a large TV screen.

A modern lobby with a pool view, orange seating, and a wooden accent wall.

7. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

Guadalupe

₩140,815

₩160,773 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A golf course with a mountain backdrop, surrounded by desert vegetation.

A lounge area with a grand piano, blue seating, and a stone wall.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

8. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

Darrick

₩148,736

₩249,326 total

includes taxes & fees

Oct 4 - Oct 5

A modern infinity pool with a view of mountains and a sunset.

A poolside lounge with a view of a hotel building, a TV, and a bar area with a bottle of champagne.

A modern bar area with a unique ceiling design, a bar counter with multiple screens, and a patterned carpet.

A restaurant with high tables and booths, floral wall decorations, and a view of the mountains.

9. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Meghan Rebbecca

₩278,299

₩355,919 total

includes taxes & fees

Oct 5 - Oct 6

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

A modern hotel lobby with a bar area, seating, a coffee machine, and a TV.

A bar area with a bar counter, multiple chairs, and a sofa.

10. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

cody

₩136,374

₩155,426 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, desk, chair, television, fireplace, and a dining area.

A hotel room with a bed, a desk with a TV, a sofa, and a coffee table.

A breakfast buffet with various food items and a coffee machine.

A reception area with a counter, two armchairs, and a round table.

11. Sonesta ES Suites Scottsdale Paradise Valley

14 km from Mayo Clinic Scottsdale

Michael

₩163,833

₩186,721 total

includes taxes & fees

Oct 14 - Oct 15

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

A Courtyard by Marriott hotel with a modern design, featuring a covered entrance and stone pillars.

A modern bar area with seating, a digital menu display, and a beverage refrigerator.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and outdoor seating.

12. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

₩197,683

₩225,299 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a large bed, a dining table with chairs, a sofa, a television, and a kitchenette.

A hotel room with a desk, chair, television, lamp, and a framed artwork on the wall.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and palm trees.

A hotel gym with dumbbells on racks, a bench, and a mirror.

13. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Melanie

₩123,533

₩140,791 total

includes taxes & fees

Nov 1 - Nov 2

A hotel dining area with a table and chairs, patterned curtains, and a view through large windows.

A golf course with sand bunkers, a flagstick, and mountains in the background.

A building entrance with a stone facade, large glass doors, and potted plants.

A hotel room with a large window, a desk, a bed, a TV, and a chair.

14. Hampton Inn & Suites Scottsdale at Talking Stick

9.1 km from Mayo Clinic Scottsdale

Mark

₩156,954

₩178,958 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio area with round tables and chairs, a pool in the background, and a covered seating area.

A hotel room with a desk, a bed, a TV, a sofa, a small table, and a view of the outdoors.

A hotel reception area with a large bridge mural, a reception desk, and a snack bar.

A hotel room with a bed, a desk, a chair, a sofa, a small table, and a TV.

15. Staybridge Suites Scottsdale - Talking Stick by IHG

9.7 km from Mayo Clinic Scottsdale

Gentry

₩223,408

₩254,729 total

includes taxes & fees

Oct 26 - Oct 27

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

A modern hotel lobby with a curved reception desk, seating area with sofas and chairs, and a large wall with a 'HOME2' sign.

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

A hotel pool area with multiple lounge chairs, a small pool, and a building with a sign.

16. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

₩162,642

₩185,443 total

includes taxes & fees

Nov 1 - Nov 2

A resort with multiple buildings, a large pool area, and surrounding mountains.

Three people in a swimming pool with rocks and a red umbrella in the background.

A dining area with a table and chairs, a view of a cityscape, and decorative wall panels.

A dining area with a table set for six, overlooking a scenic landscape.

17. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Karen

₩314,126

₩412,750 total

includes taxes & fees

Oct 2 - Oct 3

A breakfast bar with a variety of baked goods and a sign indicating fresh baked items.

A Holiday Inn & Suites building with a curved facade, multiple balconies, and a well-lit entrance.

A hotel room with a sofa, a chair, a desk with a television, a lamp, and a framed artwork on the wall.

A hotel room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a large window with a view.

18. Holiday Inn & Suites Scottsdale North - Airpark by IHG

9.7 km from Mayo Clinic Scottsdale

Ally Marie

₩188,205

₩214,499 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with stone walls, comfortable seating, and a large window offering a mountain view.

A spacious outdoor lounge area with a fire feature, comfortable seating, a bar with a view, and a stone wall.

A spacious lobby with a central table set for a small gathering, flanked by seating and a modern ceiling design.

A spacious living area with a large sectional sofa, wooden coffee tables, and a stone wall.

19. Hilton North Scottsdale At Cavasson

13.4 km from Mayo Clinic Scottsdale

Marcos

₩372,456

₩424,490 total

includes taxes & fees

Oct 9 - Oct 10

A modern hotel lobby with a long bar area, multiple seating options, and large windows offering views of palm trees and a pool.

A swimming pool with lounge chairs and palm trees, surrounded by a building with multiple windows and a covered patio area.

A modern kitchen with dark wooden cabinets, a white countertop, and a black refrigerator.

A Hampton Inn & Suites with a stone facade, a welcoming entrance, and a clear sky at dusk.

20. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

Central Scottsdale, 12.3 km from Mayo Clinic Scottsdale

Dana

₩215,393

₩245,483 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Inn at Eagle Mountain	9.0 Wonderful 1,019 reviews	View
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very good 1,103 reviews	View
Home2 Suites by Hilton Mesa Longbow, AZ	9.6 Exceptional 906 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	9.2 Wonderful 2,034 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	8.8 Excellent 1,864 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

ADERO Scottsdale Resort, Autograph Collection

10/10 Excellent

"Great rooms and hotel, staff very helpful at all times and the relaxation was perfect."

Inn at Eagle Mountain

8/10 Good

"This was the perfect respite for days of appointments at Mayo."

Spark by Hilton Fountain Hills Scottsdale

10/10 Excellent

"Great parking."

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

10/10 Excellent

"Quality service"

Wekopa Casino Resort

10/10 Excellent

"Prompt valet, quick check-in, clean room with everything you need and a comfy bed. Convenient food/bev downstairs any time, good casino, worth the extra drive time to get there."

Great Wolf Lodge Arizona

10/10 Excellent

"Facilities are amazing for families with kids. Please note there’s no in-room safe for your money,passports belonging."

Aiden by Best Western Scottsdale North

8/10 Good

"Hot tub was not working, 11 dollars for typical breakfast that is usually free."

Fountain Park Hotel, BW Signature Collection

10/10 Excellent

"We will return to this hotel."

Hampton Inn & Suites Scottsdale at Talking Stick

10/10 Excellent

"It’s what I usually expect for a Hampton Inn. Clean, cheap, easy quiet. No surprises. The free waffles closed the deal."

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 22 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 22 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

Find hotels near Mayo Clinic Scottsdale, Phoenix from ₩119,153

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Our top choices for Mayo Clinic Scottsdale hotels

1. Inn at Eagle Mountain

2. Sonesta Select Scottsdale at Mayo Clinic Campus

3. Home2 Suites by Hilton Mesa Longbow, AZ

4. Comfort Suites Scottsdale Talking Stick Entertainment District

5. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

6. Spark by Hilton Fountain Hills Scottsdale

7. Fountain Park Hotel, BW Signature Collection

8. Wekopa Casino Resort

9. Talking Stick Resort

10. Aiden by Best Western Scottsdale North

11. Sonesta ES Suites Scottsdale Paradise Valley

12. Courtyard Scottsdale Salt River

13. Holiday Inn Express Scottsdale North by IHG

14. Hampton Inn & Suites Scottsdale at Talking Stick

15. Staybridge Suites Scottsdale - Talking Stick by IHG

16. Tru By Hilton Scottsdale Salt River

17. ADERO Scottsdale Resort, Autograph Collection

18. Holiday Inn & Suites Scottsdale North - Airpark by IHG

19. Hilton North Scottsdale At Cavasson

20. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

ADERO Scottsdale Resort, Autograph Collection

Inn at Eagle Mountain

Spark by Hilton Fountain Hills Scottsdale

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Wekopa Casino Resort

Great Wolf Lodge Arizona

Aiden by Best Western Scottsdale North

Fountain Park Hotel, BW Signature Collection

Hampton Inn & Suites Scottsdale at Talking Stick

Frequently asked questions