The Best Hotels Closest to Mayo Clinic Scottsdale in Phoenix for 2026

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Our top choices for Mayo Clinic Scottsdale hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

A modern living room with a fireplace, a large flat-screen TV, and comfortable seating.

A hotel courtyard with a paved walkway, palm trees, and a building with multiple balconies and a glass facade.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

0.3 km from Mayo Clinic Scottsdale

Michael

₩111,463

₩127,035 total

includes taxes & fees

Oct 1 - Oct 2

A cluster of modern, multi-story buildings with a river in the foreground.

A golf course with a pond, a clubhouse, and a hilly backdrop.

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

A dining area with a glass table, wooden chairs, and potted plants.

2. Inn at Eagle Mountain

3.1 km from Mayo Clinic Scottsdale

Andrei

₩152,603

₩174,227 total

includes taxes & fees

Sep 27 - Sep 28

A hotel lobby with a reception desk, seating area, and a large wall mural.

A hotel lobby with multiple seating areas, a reception desk, and a kitchen in the background.

A hotel room with a sofa, a desk, a chair, a bed, and a door leading to another room.

A hotel room with two beds, a desk, a lamp, and a window with curtains.

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 8.9 km from Mayo Clinic Scottsdale

Cathleen

₩96,369

₩109,837 total

includes taxes & fees

Sep 27 - Sep 28

A modern infinity pool with a view of mountains and a sunset.

A restaurant with high tables and booths, floral wall decorations, and a view of the mountains.

A modern bar area with a unique ceiling design, a bar counter with multiple screens, and a patterned carpet.

A poolside lounge with a view of a hotel building, a TV, and a bar area with a bottle of champagne.

4. Talking Stick Resort

8.8 km from Mayo Clinic Scottsdale

Meghan Rebbecca

₩287,577

₩366,501 total

includes taxes & fees

Oct 1 - Oct 2

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

A modern hotel lobby with a fireplace, seating area, kitchen, and a large TV.

A modern hotel lobby with a central bar area, seating arrangements, and a clean, contemporary design.

A reception area with a stone wall, a wooden reception desk, and a modern elevator.

5. Comfort Suites Scottsdale Talking Stick Entertainment District

9.6 km from Mayo Clinic Scottsdale

William

₩121,571

₩138,615 total

includes taxes & fees

Sep 27 - Sep 28

A wooden door with a glass panel, a doormat, and a small window above it.

A modern kitchen with white cabinets, a built-in oven, and a large window.

6. Close to Hiking! Family-friendly Mesa Retreat

13.6 km from Mayo Clinic Scottsdale

₩243,733

₩1,060,237 total

includes taxes & fees

Oct 1 - Oct 2

A hotel room with two beds, a TV, a desk, and a window with a view.

A modern office space with multiple desks, chairs, and a meeting area.

A modern hotel room with a large window, a desk with a lamp, a microwave, and a chair.

A pool area with a clear blue pool, lounge chairs, and a multi-story building with balconies.

7. Spark by Hilton Fountain Hills Scottsdale

7.6 km from Mayo Clinic Scottsdale

Peyton

₩104,372

₩119,162 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

A golf course with a mountain backdrop, surrounded by desert vegetation.

A dining area with a large table set for six, surrounded by chairs, with a view of cacti and a stone wall outside.

A historic building with arched entrances and a bell tower, surrounded by cacti and desert landscaping.

8. Wekopa Casino Resort

10.3 km from Mayo Clinic Scottsdale

Darrick

₩148,745

₩249,340 total

includes taxes & fees

Oct 4 - Oct 5

A spacious living area with a kitchen, modern furniture, and a fireplace.

A modern kitchen with blue cabinets, a stainless steel refrigerator, and a white countertop.

A modern lobby with a pool view, orange seating, and a wooden accent wall.

A spacious lobby with a high ceiling, modern chandeliers, a fire feature, and a large TV screen.

9. Fountain Park Hotel, BW Signature Collection

7.3 km from Mayo Clinic Scottsdale

Guadalupe

₩127,283

₩145,320 total

includes taxes & fees

Sep 27 - Sep 28

A circular fire feature with a stone border, surrounded by a landscaped garden with cacti and shrubs, under a sunset sky.

A Courtyard by Marriott hotel with a modern design, featuring a covered entrance and stone pillars.

A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and outdoor seating.

A modern bar area with seating, a digital menu display, and a beverage refrigerator.

10. Courtyard Scottsdale Salt River

12.2 km from Mayo Clinic Scottsdale

Karl

₩197,694

₩225,312 total

includes taxes & fees

Oct 4 - Oct 5

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

A modern hotel lobby with a reception desk, marble counter, and a seating area with tables and chairs.

A bar area with a bar counter, multiple chairs, and a sofa.

A swimming pool with a tiled edge, lounge chairs, and a fitness area with treadmills and exercise equipment.

11. Aiden by Best Western Scottsdale North

8.7 km from Mayo Clinic Scottsdale

cody

₩117,624

₩134,057 total

includes taxes & fees

Sep 27 - Sep 28

A resort with multiple buildings, a large pool area, and surrounding mountains.

A dining area with a table and chairs, a view of a cityscape, and decorative wall panels.

Three people in a swimming pool with rocks and a red umbrella in the background.

An outdoor wedding reception with round tables set with white chairs, floral centerpieces, and a view of the city in the background.

12. ADERO Scottsdale Resort, Autograph Collection

3.6 km from Mayo Clinic Scottsdale

Karen

₩313,806

₩412,380 total

includes taxes & fees

Sep 27 - Sep 28

A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

A hotel pool area with multiple lounge chairs, a small pool, and a building with a sign.

An outdoor patio with round tables and white wicker chairs, red umbrellas, and a brick building in the background.

A modern hotel lobby with a curved reception desk, seating area with sofas and chairs, and a large wall with a 'HOME2' sign.

13. Tru By Hilton Scottsdale Salt River

8.9 km from Mayo Clinic Scottsdale

Colleen

₩148,891

₩169,766 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, a dining table with chairs, a sofa, a television, and a kitchenette.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and palm trees.

A hotel room with a desk, chair, television, lamp, and a framed artwork on the wall.

A hotel breakfast area with a self-serve station, seating, and a trash bin.

14. Holiday Inn Express Scottsdale North by IHG

Central Scottsdale, 12 km from Mayo Clinic Scottsdale

Melanie

₩114,741

₩130,770 total

includes taxes & fees

Sep 30 - Oct 1

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

A multi-story hotel with a parking lot and a road leading to a roundabout.

A bar area with a long counter, multiple bar stools, and overhead lighting.

A hotel room with two beds, a desk, a sofa, and a TV.

15. Hyatt Place North Scottsdale

14.1 km from Mayo Clinic Scottsdale

Ana

₩145,156

₩165,435 total

includes taxes & fees

Sep 27 - Sep 28

A hotel pool area with sun loungers, a children's play area, and a building with a sign.

A hotel room with a bed, a green sofa, a TV, a desk, and a green carpet.

A modern kitchen with a central island, bar stools, and a sign that reads "inspired table".

16. Home2 Suites by Hilton Scottsdale Salt River

9.6 km from Mayo Clinic Scottsdale

Kate

₩162,550

₩185,339 total

includes taxes & fees

Sep 27 - Sep 28

A breakfast bar with a variety of baked goods and a sign indicating fresh baked items.

A Holiday Inn & Suites building with a curved facade, multiple balconies, and a well-lit entrance.

A hotel room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a large window with a view.

A hotel room with a sofa, a chair, a desk with a television, a lamp, and a framed artwork on the wall.

17. Holiday Inn & Suites Scottsdale North - Airpark by IHG

9.7 km from Mayo Clinic Scottsdale

Ally Marie

₩173,478

₩197,712 total

includes taxes & fees

Sep 29 - Sep 30

A spacious lobby with a high ceiling, multiple seating areas, a reception desk, and a television screen.

A spacious hotel lobby with a reception desk, seating areas, and a view of the dining and kitchen areas.

A multi-story hotel with a flat roof and balconies, surrounded by well-maintained grass and trees.

An outdoor seating area with a fire feature, surrounded by a fence and palm trees, under a sunset sky.

18. Embassy Suites by Hilton Phoenix Scottsdale

17.8 km from Mayo Clinic Scottsdale

Maria Antoinette

₩187,647

₩212,172 total

includes taxes & fees

Oct 4 - Oct 5

A modern hotel lobby with a long bar area, multiple seating options, and large windows offering views of palm trees and a pool.

A swimming pool with lounge chairs and palm trees, surrounded by a building with multiple windows and a covered patio area.

A modern kitchen with dark wooden cabinets, a white countertop, and a black refrigerator.

A Hampton Inn & Suites with a stone facade, a welcoming entrance, and a clear sky at dusk.

19. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

Central Scottsdale, 12.3 km from Mayo Clinic Scottsdale

Dana

₩187,247

₩213,405 total

includes taxes & fees

Oct 1 - Oct 2

A hotel dining area with a table and chairs, patterned curtains, and a view through large windows.

A building entrance with a stone facade, large glass doors, and potted plants.

A hotel room with a large window, a desk, a bed, a TV, and a chair.

A hotel lobby with a bar area, seating, and a reception desk.

20. Hampton Inn & Suites Scottsdale at Talking Stick

9.1 km from Mayo Clinic Scottsdale

Mark

₩147,594

₩168,287 total

includes taxes & fees

Sep 27 - Sep 28

View all properties

Compare popular hotels close to Mayo Clinic Scottsdale

Property	Property class	Guest rating
Sonesta Select Scottsdale at Mayo Clinic Campus	8.4 Very good 1,101 reviews	View
Inn at Eagle Mountain	9.0 Wonderful 1,016 reviews	View
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale	8.8 Excellent 1,857 reviews	View
Talking Stick Resort	9.4 Exceptional 5,114 reviews	View
Comfort Suites Scottsdale Talking Stick Entertainment District	9.2 Wonderful 2,028 reviews	View

Top Mayo Clinic Scottsdale Hotel Reviews

Staybridge Suites Scottsdale - Talking Stick by IHG

10/10 Excellent

"The breakfast was fantastic!!"

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

10/10 Excellent

"Room very clean"

Hampton Inn & Suites Scottsdale at Talking Stick

10/10 Excellent

"Wonderfull Breakfast!!! Quiet and friendly!!! Thank you!!"

Holiday Inn & Suites Scottsdale North - Airpark by IHG

10/10 Excellent

"Clean room and helpful staff. Definitely would stay again"

Sonesta Select Scottsdale at Mayo Clinic Campus

8/10 Good

"Beds where comfortable, but the air conditioning unit in our room was so loud, my earplugs hardly drowned out the sound"

Inn at Eagle Mountain

8/10 Good

"Clean room staff was helpful balcony was nice and the parking was convenient"

Wekopa Casino Resort

10/10 Excellent

"It was a very nice stay."

ADERO Scottsdale Resort, Autograph Collection

10/10 Excellent

"."

Great Wolf Lodge Arizona

8/10 Good

"It was an amazing time but had one staff member be a bit rude while buying alcohol clearly paid for special cup and gave me whatever she wanted and still charged me. Didn’t want to make a big deal but other than that it’s was nice clean fun"

Frequently asked questions

What's the area like around Mayo Clinic Scottsdale?

Mayo Clinic Scottsdale is located in a welcoming area of Scottsdale known for its array of dining options and sporting events. If you're looking for a convenient place to stay, check out the 21 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mayo Clinic Scottsdale?

Adjacent to Mayo Clinic Scottsdale, Sonesta Select Scottsdale at Mayo Clinic Campus is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices within 5 miles include ADERO Scottsdale Resort, Autograph Collection and Inn at Eagle Mountain.

How many hotels will I be able to find close to Mayo Clinic Scottsdale?

Expedia has 21 hotels and other accommodations within a mile from Mayo Clinic Scottsdale.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Scottsdale, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to view top deals close to Mayo Clinic Scottsdale.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Scottsdale?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Scottsdale, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Scottsdale?

You might spend a leisurely day outdoors at Scottsdale Ranch Park and Fountain Hills Botanical Garden. Explore nature at Desert Sonoran Botanical Garden Trailhead and Golden Eagle Trailhead. Eagle Mountain Golf Course, Golf Club at Eagle Mountain, or SunRidge Canyon Golf Club are some local sights worth checking out.

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Our top choices for Mayo Clinic Scottsdale hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Inn at Eagle Mountain

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

4. Talking Stick Resort

5. Comfort Suites Scottsdale Talking Stick Entertainment District

6. Close to Hiking! Family-friendly Mesa Retreat

7. Spark by Hilton Fountain Hills Scottsdale

8. Wekopa Casino Resort

9. Fountain Park Hotel, BW Signature Collection

10. Courtyard Scottsdale Salt River

11. Aiden by Best Western Scottsdale North

12. ADERO Scottsdale Resort, Autograph Collection

13. Tru By Hilton Scottsdale Salt River

14. Holiday Inn Express Scottsdale North by IHG

15. Hyatt Place North Scottsdale

16. Home2 Suites by Hilton Scottsdale Salt River

17. Holiday Inn & Suites Scottsdale North - Airpark by IHG

18. Embassy Suites by Hilton Phoenix Scottsdale

19. Hampton Inn & Suites Phoenix/Scottsdale on Shea Boulevard

20. Hampton Inn & Suites Scottsdale at Talking Stick

Compare popular hotels close to Mayo Clinic Scottsdale

Top Mayo Clinic Scottsdale Hotel Reviews

Staybridge Suites Scottsdale - Talking Stick by IHG

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Hampton Inn & Suites Scottsdale at Talking Stick

Holiday Inn & Suites Scottsdale North - Airpark by IHG

Sonesta Select Scottsdale at Mayo Clinic Campus

Inn at Eagle Mountain

Wekopa Casino Resort

ADERO Scottsdale Resort, Autograph Collection

Great Wolf Lodge Arizona

Frequently asked questions