Find hotels in Medical District, Greenville

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Dec 19 - Dec 20
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Dec 20 - Dec 21
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Dec 19 - Dec 21
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Dec 26 - Dec 28

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Our top choices for Medical District hotels

Reception
Courtyard Marriott Greenville

Courtyard Marriott Greenville

Courtyard Marriott Greenville
3.0 star property
Medical District
8.8 out of 10, Excellent, (881)
"Clean rooms, friendly staff and great location. Enjoyed our stay."
United States
Frederick
The price is ₩174,201
₩196,847 total
includes taxes & fees
Dec 28 - Dec 29
Courtyard Marriott Greenville
Suite, 1 Bedroom, Non Smoking, Jetted Tub | Down comforters, desk, iron/ironing board, free WiFi
Country Inn & Suites by Radisson, Greenville, NC

Country Inn & Suites by Radisson, Greenville, NC

Country Inn & Suites by Radisson, Greenville, NC
3.0 star property
5.8 km from Medical District
7.6 out of 10, Good, (820)
"Staff was very friendly and property was in a convenient location "
United States
Michele
The price is ₩138,047
₩157,469 total
includes taxes & fees
Dec 25 - Dec 26
Country Inn & Suites by Radisson, Greenville, NC
Exterior
Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG
3.0 star property
0.8 km from Medical District
9.4 out of 10, Exceptional, (242)
"I enjoyed my stay very clean and comfortable "
United States
LATONYA
The price is ₩147,628
₩166,820 total
includes taxes & fees
Dec 21 - Dec 22
Staybridge Suites Greenville Medical Center by IHG
Terrace/patio
Residence Inn by Marriott Greenville

Residence Inn by Marriott Greenville

Residence Inn by Marriott Greenville
3.0 star property
0.6 km from Medical District
8.8 out of 10, Excellent, (466)
"Rooms are very nice, quiet "
United States
David
The price is ₩163,867
₩185,170 total
includes taxes & fees
Dec 23 - Dec 24
Residence Inn by Marriott Greenville
Terrace/patio
Hilton Greenville

Hilton Greenville

Hilton Greenville
4.0 star property
Convention District, 4.2 km from Medical District
8.8 out of 10, Excellent, (532)
"Hotel was very nice and clean. "
United States
Marcie
The price is ₩204,583
₩231,178 total
includes taxes & fees
Dec 28 - Dec 29
Hilton Greenville
Property amenity
Fairfield Inn & Suites by Marriott Greenville

Fairfield Inn & Suites by Marriott Greenville

Fairfield Inn & Suites by Marriott Greenville
2.5 star property
0.9 km from Medical District
8.6 out of 10, Excellent, (457)
"Convenient to Maynard children’s hospital. Friendly staff. Safe environment "
United States
DARLENE
The price is ₩174,201
₩196,846 total
includes taxes & fees
Dec 21 - Dec 22
Fairfield Inn & Suites by Marriott Greenville
Terrace/patio
Hampton Inn Greenville

Hampton Inn Greenville

Hampton Inn Greenville
2.5 star property
Convention District, 4.1 km from Medical District
9.0 out of 10, Wonderful, (572)
"Great stay."
United States
Mario
The price is ₩175,205
₩197,982 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn Greenville
Exterior
Hilton Garden INN Greenville University

Hilton Garden INN Greenville University

Hilton Garden INN Greenville University
3.0 star property
Uptown Greenville, 2.9 km from Medical District
9.4 out of 10, Exceptional, (92)
"Great location. Rooftop bar and restaurant was nice and convenient."
United States
GEORGE
The price is ₩180,372
₩203,820 total
includes taxes & fees
Dec 28 - Dec 29
Hilton Garden INN Greenville University
Property amenity
Candlewood Suites Greenville NC by IHG

Candlewood Suites Greenville NC by IHG

Candlewood Suites Greenville NC by IHG
2.5 star property
2 km from Medical District
8.6 out of 10, Excellent, (586)
"I loved it will visit again "
United States
natalie
The price is ₩128,436
₩145,133 total
includes taxes & fees
Dec 28 - Dec 29
Candlewood Suites Greenville NC by IHG
Exterior
Holiday Inn Greenville by IHG

Holiday Inn Greenville by IHG

Holiday Inn Greenville by IHG
3.0 star property
Convention District, 4.2 km from Medical District
8.8 out of 10, Excellent, (1002)
"Nice clean room. Very friendly staff."
United States
Jennifer
The price is ₩143,052
₩161,648 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Greenville by IHG
Exterior
Holiday Inn Express Greenville by IHG

Holiday Inn Express Greenville by IHG

Holiday Inn Express Greenville by IHG
2.5 star property
0.9 km from Medical District
8.4 out of 10, Very Good, (967)
"Great location and breakfast menu "
United States
Angela
The price is ₩157,962
₩178,497 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Express Greenville by IHG
In-room safe, blackout drapes, free WiFi, bed sheets
Microtel Inn & Suites by Wyndham Greenville/University Medic

Microtel Inn & Suites by Wyndham Greenville/University Medic

Microtel Inn & Suites by Wyndham Greenville/University Medic
2.0 star property
0.6 km from Medical District
7.2 out of 10, Good, (1001)
"Staff is nice and friendly "
United States
Tonya
The price is ₩95,368
₩107,766 total
includes taxes & fees
Dec 21 - Dec 22
Microtel Inn & Suites by Wyndham Greenville/University Medic
Exterior
Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville
2.0 star property
1.1 km from Medical District
6.6 out of 10, (581)
"Staff was nice, room was clean. Had a great experience."
United States
Lashonda
The price is ₩96,623
₩109,184 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Super 8 by Wyndham Greenville
Exterior
Homewood Suites By Hilton Greenville, NC

Homewood Suites By Hilton Greenville, NC

Homewood Suites By Hilton Greenville, NC
3.0 star property
0.7 km from Medical District
9.4 out of 10, Exceptional, (307)
"Room was perfect. We really appreciate our stay. "
United States
Carol
The price is ₩170,067
₩192,175 total
includes taxes & fees
Dec 26 - Dec 27
Homewood Suites By Hilton Greenville, NC
Exterior
Quality Inn Greenville near University

Quality Inn Greenville near University

Quality Inn Greenville near University
2.5 star property
0.9 km from Medical District
7.4 out of 10, Good, (1003)
"room clean, staff check in was efficient and helpful."
United States
Lynn
The price is ₩99,649
₩112,603 total
includes taxes & fees
Dec 21 - Dec 22
Quality Inn Greenville near University
Property amenity
Fairfield Inn and Suites by Marriott Washington

Fairfield Inn and Suites by Marriott Washington

Fairfield Inn and Suites by Marriott Washington
2.5 star property
29.7 km from Medical District
9.4 out of 10, Exceptional, (627)
"Great staff, room was perfect!!"
United States
Teresa G
The price is ₩174,201
₩196,412 total
includes taxes & fees
Dec 23 - Dec 24
Fairfield Inn and Suites by Marriott Washington
Exterior
Red Roof Inn Greenville, NC

Red Roof Inn Greenville, NC

Red Roof Inn Greenville, NC
2.0 star property
4 km from Medical District
4.8 out of 10, (259)
"It was great for the price. Our room and bathroom were clean. Very close to tailgate field. Short Uber drive. We felt safe. "
United States
Stacy
The price is ₩94,100
₩106,332 total
includes taxes & fees
Dec 23 - Dec 24
Red Roof Inn Greenville, NC
Lobby
Comfort Inn & Suites Greenville Near East Carolina University

Comfort Inn & Suites Greenville Near East Carolina University

Comfort Inn & Suites Greenville Near East Carolina University
2.5 star property
4 km from Medical District
8.6 out of 10, Excellent, (393)
"I highly recomend and the staff is very friendly & helpful!"
United States
Carmen
The price is ₩164,162
₩185,504 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Inn & Suites Greenville Near East Carolina University
Standard Suite, 1 Queen Bed | Private kitchen | Microwave, oven, stovetop, coffee/tea maker
Affordable Suites Greenville

Affordable Suites Greenville

Affordable Suites Greenville
2.0 star property
2 km from Medical District
8.4 out of 10, Very Good, (579)
"Yes kitchen is fully equipped for cooking. Great hotel, quiet, clean and safe. "
United States
Susan
Affordable Suites Greenville
Free daily continental breakfast
Baymont by Wyndham Greenville

Baymont by Wyndham Greenville

Baymont by Wyndham Greenville
2.5 star property
4.6 km from Medical District
6.4 out of 10, (1003)
"Friendly staff. Nicer than other cheaper motels located in this area. Plus you got food options all around you "
United States
Ashley
The price is ₩77,926
₩88,056 total
includes taxes & fees
Jan 17 - Jan 18, 2026
Baymont by Wyndham Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Medical District

Find the best Medical District areas and neighborhoods for the activities you enjoy most.

Uptown Greenville

While visiting Uptown Greenville, you might make a stop by sights like Town Common and Greenville Museum of Art.

Westhaven

While Westhaven isn't home to many top sights, 11 Galleria and Arlington Crossing are some notable places to visit nearby.

College View Historic District

When in College View Historic District, you can plan a visit to Williams Arena at Minges Coliseum and Dowdy–Ficklen Stadium, some noteworthy sights in the nearby area.

Greenville Heights

When in Greenville Heights, you can plan a visit to North Pines and Town Common, some noteworthy sights in the nearby area.

Top Medical District Hotel Reviews

Comfort Inn & Suites Greenville Near East Carolina University

Comfort Inn & Suites Greenville Near East Carolina University

10/10 Excellent
"Clean, convenient. Staff throughout hotel very friendly. "
David 2-night trip
Posted 4 days ago
Comfort Inn & Suites Greenville Near East Carolina University

Frequently asked questions

What is Medical District like?
Travelers are sure to enjoy a stay in Greenville's Medical District neighborhood. Consider a visit to Laupus Health Sciences Library as part of your Medical District travel plans.
Where is the best place to stay in Medical District?
Based on Expedia customer reviews, Courtyard Marriott Greenville is the highest ranked property in Medical District. This hotel offers a restaurant and free parking.
If I need to cancel my hotel reservation in Medical District, will I receive a refund?
Yes, most hotel room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then filter by "fully refundable" to get top deals in Medical District.
Where can I learn more about changing or cancelling my trip to Medical District?
To access more information about updating your trip to Medical District or cancelling it, go to https://www.expedia.com/service/.
What can I see and do in this Greenville neighborhood?
Laupus Health Sciences Library is an attraction you might want to check out while you're in Medical District. When you're sightseeing in Greenville, North Pines and Guy Smith Stadium are also worth a stop.