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Compare hotels close to Museum of Life and Science with room rates, reviews, and availability. Most hotels are fully refundable.

Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

2.5 star property
1.4 km from Museum of Life and Science
9.0 out of 10, Wonderful, (1012)
"Nice place to stay and close to everything. "
United States
Christy
The price is ₩151,466
₩171,915 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

2.5 star property
2.2 km from Museum of Life and Science
8.8 out of 10, Excellent, (944)
"Love my stay , great staff"
United States
Oscar
The price is ₩139,725
₩158,589 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Express Durham by IHG
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

2.0 star property
2.2 km from Museum of Life and Science
6.8 out of 10, (1005)
"Good motel...clean, easy acess "
United States
Howard
The price is ₩85,187
₩99,186 total
includes taxes & fees
Dec 8 - Dec 9
Red Roof Inn Durham - Duke Univ Medical Center
Premium bedding, desk, blackout drapes, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

2.5 star property
Croasdaile Farm Master, 3.2 km from Museum of Life and Science
8.6 out of 10, Excellent, (1012)
"Loved our stay"
United States
Brian
The price is ₩132,314
₩150,178 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Inn & Suites Durham near Duke University
Miscellaneous
Super 8 by Wyndham Durham/University Area NC

Super 8 by Wyndham Durham/University Area NC

2.0 star property
2.1 km from Museum of Life and Science
5.0 out of 10, (344)
"The environment was not pleasant "
United States
Denise
The price is ₩93,566
₩106,203 total
includes taxes & fees
Dec 3 - Dec 4
Super 8 by Wyndham Durham/University Area NC
Apartment | 3 bedrooms
Walk to Duke Campus 3 Bedroom in Trinity Park

Walk to Duke Campus 3 Bedroom in Trinity Park

2.0 star property
Trinity Park, 2.9 km from Museum of Life and Science
The price is ₩114,859
₩310,716 total
includes taxes & fees
Dec 7 - Dec 8
Walk to Duke Campus 3 Bedroom in Trinity Park
Apartment | 2 bedrooms
Renovated 2 Bed Walltown Home Walk to Duke A

Renovated 2 Bed Walltown Home Walk to Duke A

2.0 star property
2.2 km from Museum of Life and Science
The price is ₩121,631
₩290,976 total
includes taxes & fees
Dec 8 - Dec 9
Renovated 2 Bed Walltown Home Walk to Duke A
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

3.0 star property
Trinity Park, 3.3 km from Museum of Life and Science
9.2 out of 10, Wonderful, (458)
"Hotel was great - very friendly staff."
United States
Lisa
The price is ₩168,606
₩191,368 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Residence Inn Durham McPherson/Duke University Medical Cntr
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

3.0 star property
9th Street District, 3.4 km from Museum of Life and Science
9.2 out of 10, Wonderful, (1007)
"Clean rooms, nice staff. Clean hotel. Ample parking. "
United States
Emana
The price is ₩179,691
₩203,951 total
includes taxes & fees
Dec 21 - Dec 22
Hilton Garden Inn Durham/University Medical Center
BBQ/picnic area
Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown

3.0 star property
Croasdaile Farm Master, 3.3 km from Museum of Life and Science
8.2 out of 10, Very Good, (1011)
"Staff was wonderful, hotel clean, & location was perfect!"
United States
Gena
The price is ₩154,696
₩175,580 total
includes taxes & fees
Dec 14 - Dec 15
Courtyard Durham Near Duke University/Downtown
Outdoor pool
Royal Inn

Royal Inn

2.0 star property
4.4 km from Museum of Life and Science
5.8 out of 10, (1030)
"Awful “hotel”"
United Kingdom
Andrew
The price is ₩117,401
₩133,252 total
includes taxes & fees
Dec 3 - Dec 4
Royal Inn
Exterior
SureStay Plus Hotel by Best Western Durham Medical Center

SureStay Plus Hotel by Best Western Durham Medical Center

2.5 star property
5.1 km from Museum of Life and Science
5.8 out of 10, (1001)
"Staff was nice & breakfast was good."
United States
Zelma
The price is ₩97,749
₩110,944 total
includes taxes & fees
Dec 8 - Dec 9
SureStay Plus Hotel by Best Western Durham Medical Center
Premium bedding, desk, blackout drapes, iron/ironing board
The Durham Hotel

The Durham Hotel

4.0 star property
Downtown Durham, 3.6 km from Museum of Life and Science
9.0 out of 10, Wonderful, (635)
"Perfect place to stay for an easy walk to see a show at the charming Carolina Theater. Food, service and atmosphere were outstanding. "
United States
Jo
The price is ₩273,007
₩309,863 total
includes taxes & fees
Dec 14 - Dec 15
The Durham Hotel
Daily cooked-to-order breakfast (USD 19.95 per person)
Durham Marriott City Center

Durham Marriott City Center

3.5 star property
Downtown Durham, 3.6 km from Museum of Life and Science
8.8 out of 10, Excellent, (821)
"The room was clean. The staff was very helpful and the food was good. "
United States
Tia
The price is ₩185,884
₩210,980 total
includes taxes & fees
Dec 15 - Dec 16
Durham Marriott City Center
Exterior
Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt

3.5 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.2 out of 10, Very Good, (1007)
"Staff was nice, room was large and very clean, location was excellent"
United States
Janice
The price is ₩186,398
₩236,528 total
includes taxes & fees
Dec 14 - Dec 15
Unscripted Durham, Part of JDV by Hyatt
Interior entrance
21c Museum Hotel Durham

21c Museum Hotel Durham

4.0 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.4 out of 10, Very Good, (1014)
"Overall good hotel and friendly staff. Building and rooms show some age but that is part of the charm. Enjoyable stay. "
United States
Lisa H
The price is ₩237,026
₩276,382 total
includes taxes & fees
Dec 19 - Dec 20
21c Museum Hotel Durham
Front of property - evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

2.0 star property
4 km from Museum of Life and Science
8.8 out of 10, Excellent, (1010)
"Courteous staff, clean room"
United States
Bruce
The price is ₩157,576
₩178,866 total
includes taxes & fees
Dec 24 - Dec 25
University Inn Durham next to Duke University Medical Center
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

3.0 star property
American Tobacco District, 4.1 km from Museum of Life and Science
9.0 out of 10, Wonderful, (730)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is ₩248,041
₩281,527 total
includes taxes & fees
Dec 21 - Dec 22
Aloft Durham Downtown
Desk, iron/ironing board, free WiFi, bed sheets
Extended Stay America Suites Durham University

Extended Stay America Suites Durham University

2.5 star property
8.3 km from Museum of Life and Science
5.0 out of 10, (818)
"I would not recommend this place unless you are on a really tight budget. The only nice thing about it was the kind person who checked us in. The room was dingy and smelled faintly of smoke. The smoke alarm was chirping and I had to borrow tools to disconnect it so we could sleep. There was constant noise throughout the night from other guests, and the whole place smelled like weed."
United States
Derek
The price is ₩110,416
₩125,321 total
includes taxes & fees
Dec 15 - Dec 16
Extended Stay America Suites Durham University
Front of property
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

3.0 star property
4 km from Museum of Life and Science
8.4 out of 10, Very Good, (1008)
"Older property but very convenient and clean for our quick trip. "
United States
Stacie
The price is ₩189,333
₩214,893 total
includes taxes & fees
Dec 14 - Dec 15
The Lodge at Duke Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Museum of Life and Science Hotel Reviews

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

10/10 Excellent
"Short stay but very sayisfying"
PATIE 2-night trip
Posted 7 days ago
Hampton Inn & Suites Durham/North I-85

Hotels near other Museum of Life and Science attractions

Brightleaf Square

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Vietnam Veterans Living Memorial

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Frequently asked questions

What's the area like around Museum of Life and Science?
Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 9 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Museum of Life and Science?
Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.8 mi (1.4 km) from Museum of Life and Science. Other good options within 5 miles include Red Roof Inn Durham - Duke Univ Medical Center and Holiday Inn Express Durham by IHG.
How many hotels will I find close to Museum of Life and Science?
Expedia has 9 hotels and other accommodations within a mile from Museum of Life and Science.
If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?
Yes, most hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view the best deals near Museum of Life and Science.
Where can I learn more about changing or cancelling my trip in the area near Museum of Life and Science?
To access more information about picking new dates or cancelling your stay near Museum of Life and Science, go to https://www.expedia.com/service/.
What can I see and do near Museum of Life and Science?
You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium. You can watch performances at Carolina Theatre, Durham Performing Arts Center, and Manbites Dog Theater if you're interested in local theater.

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