Find hotels in Otay Mesa West, San Diego from ₩104,326

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 7 - Dec 8
Tomorrow
Dec 8 - Dec 9
Next weekend
Dec 12 - Dec 14
In two weeks
Dec 19 - Dec 21

Filter by

Guest rating
Guest rating
Star rating

Discover 6,858 Otay Mesa West hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
10.5 km from Otay Mesa West
9.2 out of 10, Wonderful, (3491)
"Clean room nice staff right off of the freeway. "
United States
Olivia
The price is ₩171,031
₩188,467 total
includes taxes & fees
Dec 14 - Dec 15
Best Western Plus Marina Gateway Hotel
Rooftop terrace
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 18.1 km from Otay Mesa West
8.8 out of 10, Excellent, (2085)
"Room was spotless and location great. "
United States
James
The price is ₩204,748
₩237,390 total
includes taxes & fees
Dec 14 - Dec 15
Palihotel San Diego Gaslamp Quarter
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
Marina District, 17.8 km from Otay Mesa West
9.0 out of 10, Wonderful, (2697)
"Clean facilities and friendly staff!"
United States
EMMA
The Horton Grand, Downtown/Gaslamp Quarter
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
19.2 km from Otay Mesa West
8.4 out of 10, Very Good, (6069)
"Always an amazing stay"
United States
Jana
The price is ₩199,077
₩273,537 total
includes taxes & fees
Dec 9 - Dec 10
Wyndham San Diego Bayside
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1228)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is ₩201,920
₩234,116 total
includes taxes & fees
Dec 14 - Dec 15
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 17.5 km from Otay Mesa West
9.0 out of 10, Wonderful, (3141)
"Great stay"
United States
Laurence
The price is ₩222,719
₩325,992 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hard Rock Hotel San Diego
Outdoor pool, sun loungers
Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island

2.5 star property
17.3 km from Otay Mesa West
8.8 out of 10, Excellent, (1001)
"Good to spend a night or two-- nice staff-- friendly ad awesome breakfast"
United States
MICHELE
The price is ₩231,071
₩254,178 total
includes taxes & fees
Dec 14 - Dec 15
Best Western Plus Suites Hotel Coronado Island
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 18.2 km from Otay Mesa West
9.0 out of 10, Wonderful, (1006)
"Great room, clean, spacious and quiet. "
United States
Maria
The price is ₩163,504
₩185,985 total
includes taxes & fees
Dec 9 - Dec 10
Gaslamp Plaza Suites
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
18.5 km from Otay Mesa West
8.6 out of 10, Excellent, (1443)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
18.5 km from Otay Mesa West
8.4 out of 10, Very Good, (1652)
"Great location and history to the hotel "
United States
Stephanie
The Sofia Hotel
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 17.8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1007)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is ₩178,970
₩250,077 total
includes taxes & fees
Dec 26 - Dec 27
Staypineapple, Hotel Z, Gaslamp San Diego
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 star property
22.1 km from Otay Mesa West
9.2 out of 10, Wonderful, (3171)
"Great stay and location!"
United States
Jason
The price is ₩157,759
₩181,335 total
includes taxes & fees
Dec 8 - Dec 9
Bay Club Hotel & Marina
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

3.0 star property
North Pacific Beach, 29.8 km from Otay Mesa West
8.0 out of 10, Very Good, (1425)
"Great place We will stay here again. "
United States
Derek
The price is ₩142,587
₩163,931 total
includes taxes & fees
Dec 14 - Dec 15
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Front of property - evening/night
Glorietta Bay Inn Coronado Island

Glorietta Bay Inn Coronado Island

3.5 star property
16.3 km from Otay Mesa West
8.6 out of 10, Excellent, (1000)
"Great location Main Street. Orange ave is literally to the right of hotel walking to everything beautiful setting cozy rooms feels like your in a villa with small little outside rooms with patio or balcony Breakfast on the patio nice pool and professional staff "
United States
Diane
The price is ₩299,242
₩398,261 total
includes taxes & fees
Dec 8 - Dec 9
Glorietta Bay Inn Coronado Island
2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
Marina District, 17.9 km from Otay Mesa West
9.2 out of 10, Wonderful, (1939)
"Great hotel"
United States
Farzana
The price is ₩234,209
₩349,019 total
includes taxes & fees
Dec 18 - Dec 19
Marriott Marquis San Diego Marina
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1159)
"Amenities and location were great. "
United States
Julie
The price is ₩237,302
₩334,915 total
includes taxes & fees
Dec 14 - Dec 15
Margaritaville Hotel San Diego Gaslamp Quarter
Outdoor pool, pool umbrellas, sun loungers
Heritage Inn La Mesa

Heritage Inn La Mesa

2.0 star property
21.9 km from Otay Mesa West
7.0 out of 10, Good, (1190)
"room was clean and staff very friendly"
United States
Charles
The price is ₩93,266
₩102,887 total
includes taxes & fees
Dec 9 - Dec 10
Heritage Inn La Mesa
Check-in/check-out kiosk
Urban Boutique Hotel

Urban Boutique Hotel

3.0 star property
Little Italy, 19.3 km from Otay Mesa West
8.6 out of 10, Excellent, (1277)
"Locations is excellent and the front desk lady was friendly "
Canada
Ju
Urban Boutique Hotel
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillowtop beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
19.1 km from Otay Mesa West
8.8 out of 10, Excellent, (717)
"Great staff, great location, great value. "
United States
Juan
The price is ₩152,015
₩176,254 total
includes taxes & fees
Dec 15 - Dec 16
The DEXTRO Little Italy, BW Premier Collection
Exterior
La Pensione Hotel

La Pensione Hotel

3.0 star property
Little Italy, 19.4 km from Otay Mesa West
8.6 out of 10, Excellent, (1903)
"Friendly staff, very nice room, great location!"
United States
Lisa
La Pensione Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most.
US Grant Hotel

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Pacific Beach Park showing a beach

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Belmont Park showing rides and a garden

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Ocean Beach

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa West Hotel Reviews

The Dana on Mission Bay

The Dana on Mission Bay

10/10 Excellent
"The room was very clean and the staff was friendly and helpful. The restaurant had good food. The waitstaff were very responsive to requests and very professional."
Elizabeth 4-night trip
Posted 2 days ago
The Dana on Mission Bay

Explore a world of travel with Expedia

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighborhood that travelers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes, you'll find most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the top deals on offer in Otay Mesa West.
Where can I learn more about changing or cancelling my trip to Otay Mesa West?
To find more details about rescheduling or cancelling your trip to Otay Mesa West, click here.
What is there to do around this San Diego neighborhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets, and Sesame Place San Diego. While you're out sightseeing in San Diego, be sure to visit other sights like Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.