What is Otay Mesa West like?

Otay Mesa West is a neighborhood that travelers like for its cathedral.

How many hotels can I expect to find in the Otay Mesa West area?

When you want to find places to stay in San Diego, start by booking one of Expedia's 5 hotels and other accommodations in Otay Mesa West.

If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?

Yes, you'll find most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the top deals on offer in Otay Mesa West.

Where can I learn more about changing or cancelling my trip to Otay Mesa West?

To find more details about rescheduling or cancelling your trip to Otay Mesa West, click here .

What is there to do around this San Diego neighborhood?

A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets, and Sesame Place San Diego. While you're out sightseeing in San Diego, be sure to visit other sights like Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.

How can I get around Otay Mesa West and the greater San Diego area?

Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.

Top Otay Mesa West Hotels from ₩105,311

Discover 6,555 Otay Mesa West hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Relax by the resort pool surrounded by palm trees and a pebble bed.

"Great place to stay beautiful casino! "

₩191,596 total

includes taxes & fees

Aug 18 - Aug 19

Relax in this serene space with a large bed, ocean-inspired artwork, and a cozy reading nook by the window.

"Cozy bed, very quiet and convenient"

₩169,923 total

includes taxes & fees

Aug 17 - Aug 18

Welcome to the reception area, where a friendly staff is available to assist with your stay. A staircase leads to additional floors, and a clock keeps perfect time.

"Convenient, one night stay."

₩156,764 total

includes taxes & fees

Jul 29 - Jul 30

Relax in the stylish lobby, featuring a reception desk, comfortable seating area, and decorative shelving unit.

"Staff was friendly, hotel was clean and breakfast was great"

₩186,584 total

includes taxes & fees

Aug 17 - Aug 18

Relax by the ocean with a clear view from this pool area, surrounded by lounge chairs and tables under the shade of palm trees.

"Enjoyed our stay. Pool, breakfast and room was amazing."

₩247,298 total

includes taxes & fees

Aug 10 - Aug 11

Relax in a comfortable seating area surrounded by lush greenery and a bar.

"Very nice hotel"

₩236,301 total

includes taxes & fees

Aug 3 - Aug 4

Relax by the pool surrounded by a deck with comfortable seating and umbrellas.

"Familiar stay"

₩116,119 total

includes taxes & fees

Jul 28 - Jul 29

Relax by the pool surrounded by lounge chairs and umbrellas, with a lifeguard on duty.

"Clean rooms, simple checkin, plenty of parking"

₩256,415 total

includes taxes & fees

Aug 24 - Aug 25

Relax in a well-appointed room with a comfortable seating area, desk, and coffee station.

"Clean, great staff. "

₩178,936 total

includes taxes & fees

Aug 24 - Aug 25

Experience the charm of this historic hotel, featuring a striking bell tower and sheltered entrance.

"Love the breakfast and convenient location. "

₩184,009 total

includes taxes & fees

Jul 28 - Jul 29

Two single beds with geometric-patterned bedding and a dark headboard, set against a backdrop of white and blue walls.

"Great stay"

₩130,191 total

includes taxes & fees

Jul 28 - Jul 29

Relax in a spacious room with a large bed, wooden desk, and comfortable seating area.

"Staff was friendly hotel was clean and easy day trips back and forth throughout San Diego area."

₩141,205 total

includes taxes & fees

Jul 28 - Jul 29

Two large beds with white linens and wooden headboards, a flat-screen TV, and a desk with a lamp.

"It’s a very nice clean and friendly people in the property"

₩191,567 total

includes taxes & fees

Aug 24 - Aug 25

Stunning hotel entrance with arched design, surrounded by lush greenery and a palm tree.

"Nice hotel "

₩141,074 total

includes taxes & fees

Aug 4 - Aug 5

Guests can park adjacent to the building, with a covered entrance nearby.

"Great rooms ,Awesome staff. And pet friendly!!! "

₩116,458 total

includes taxes & fees

Jul 28 - Jul 29

Relax in a serene space with a large bed, desk, and comfortable seating area.

"Great place to stay!"

₩153,145 total

includes taxes & fees

Jul 28 - Jul 29

Contemporary bathroom with sleek countertop, white sink, and large mirror.

"Enjoyed our stay"

₩165,371 total

includes taxes & fees

Aug 10 - Aug 11

Relax by the pool surrounded by palm trees and a city view.

"Great place"

₩162,503 total

includes taxes & fees

Aug 10 - Aug 11

Enjoy cooking in this well-equipped kitchen with appliances and a dining area.

"Great location within walking distance from the places we wanted to visit."

₩132,585 total

includes taxes & fees

Aug 15 - Aug 16

Relax by the pool surrounded by lounge chairs and umbrellas.

"Very pleased with this stay."

₩189,558 total

includes taxes & fees

Aug 17 - Aug 18

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most.

Downtown San Diego

2 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

See properties

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

See properties

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

See properties

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

See properties

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

See properties

Top Otay Mesa West Hotel Reviews

Bay Club Hotel & Marina

10/10 Excellent

"The hotel was in a great location on the bay. The staff was very efficient and helpful. I ate dinner there one night and it was delicious. Beautiful lobby, too. I would absolutely stay there again. "

Marriott Marquis San Diego Marina

10/10 Excellent

"I had a great experience at this hotel! Everything was spotlessly clean, and the service was excellent!friendly, helpful staff made me feel welcome from the moment I arrived. The location is also a big plus—within easy walking distance to lots of entertainment, restaurants, and attractions. I would definitely stay here again! The only thing I’d note is that the parking structure could use some improvements—it was a bit dark and felt somewhat isolated at times. Better lighting and visibility would make it feel safer. Still, overall a fantastic stay. Highly recommend!"

Members save 10% or more on over 100,000 hotels worldwide when you’re signed in

Find hotels in Otay Mesa West, San Diego from ₩105,311

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Otay Mesa West

Check prices for these dates

Filter by

Discover 6,555 Otay Mesa West hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Sycuan Casino Resort

Sycuan Casino Resort

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon

Super 8 by Wyndham El Cajon/San Diego

Super 8 by Wyndham El Cajon/San Diego

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista

Heritage Inn La Mesa

Heritage Inn La Mesa

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Valli Hi Motel

Valli Hi Motel

Best Western Americana Inn

Best Western Americana Inn

Chula Vista Inn

Chula Vista Inn

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique

Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South

SureStay Hotel by Best Western Chula Vista San Diego Bay

SureStay Hotel by Best Western Chula Vista San Diego Bay

Berkshire Motor Hotel

Berkshire Motor Hotel

The Rambler Motel

The Rambler Motel

Where to stay in Otay Mesa West

Downtown San Diego

Mission Beach

Pacific Beach

Gaslamp Quarter

Ocean Beach

Top Otay Mesa West Hotel Reviews

Bay Club Hotel & Marina

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Hotels in top San Diego neighborhoods

Hotels near popular San Diego Attractions

More Accommodation Types in Otay Mesa West

Hotels Close to Nearby Airports

Explore more hotels

More ways to book

Expedia's Latest Trends

Frequently asked questions