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Dec 26 - Dec 27
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Dec 27 - Dec 28
This weekend
Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for Sanctuary hotels

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Matlacha on Shoreview

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (215)
"Place was great. Nice and neat perfect for what i needed."
United States
Michael
The price is ₩94,147
₩201,873 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Matlacha on Shoreview
Balcony view
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1003)
"Beautiful place "
United States
Blaine
The price is ₩104,389
₩126,497 total
includes taxes & fees
Dec 28 - Dec 29
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1000)
"Excellent stay over Thanksgiving holiday!"
United States
Nicole
The price is ₩291,826
₩383,322 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Westin Cape Coral Resort At Marina Village
Exterior
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.6 out of 10, Excellent, (1001)
"The rooms were clean, staff were very friendly and accommodating."
United States
Sandra
The price is ₩176,432
₩196,722 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
Terrace/patio
Dolphin Key Resort

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1213)
"Nice rooms, great having the bar onsite"
United States
Lee
The price is ₩115,873
₩129,198 total
includes taxes & fees
Dec 29 - Dec 30
Dolphin Key Resort
Free buffet breakfast
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1086)
"Is great place to stay."
United States
Anastassia
The price is ₩190,612
₩212,532 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Economy Studio (Turtle) | Private kitchen
TriLuxe Inn & Studios

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very Good, (17)
"Everything was great, will definitely be coming back"
United States
Ruben
The price is ₩102,526
₩161,009 total
includes taxes & fees
Dec 28 - Dec 29
TriLuxe Inn & Studios
Deluxe Studio Suite | Terrace/patio
White Orchid Apartments

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.0 out of 10, Very Good, (49)
"Place was nice and private. "
United States
Dawn
The price is ₩99,940
₩158,268 total
includes taxes & fees
Dec 27 - Dec 28
White Orchid Apartments
Basic Studio | Private kitchen | Dining tables
Summerwind Studios

Summerwind Studios

Summerwind Studios
2.0 star property
22.6 km from Sanctuary
8.0 out of 10, Very Good, (11)
"Very clean and roomy. Quiet neighborhood. Loves the shower; so relaxing. Only complaint is that we could have used some drinking glasses. I would stay here again. "
United States
Micki
The price is ₩103,970
₩162,619 total
includes taxes & fees
Dec 27 - Dec 28
Summerwind Studios
Exterior
Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (144)
"great boutique hotel in an amazing area on Pine Island Fl. Great restaurants and bars walkable and great fishing. "
United States
Pat
The price is ₩289,843
₩371,479 total
includes taxes & fees
Dec 30 - Dec 31
Off the Charts Inn & Out Island Resort
Outdoor pool, a heated pool, sun loungers
Resort Harbour Properties

Resort Harbour Properties

Resort Harbour Properties
3.5 star property
15.7 km from Sanctuary
9.6 out of 10, Exceptional, (364)
"10/10 would stay there again"
United States
Kristie
Resort Harbour Properties
Outdoor pool
Sanibel Island Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1487)
"Excellent value with a great location and a solid staff!"
United States
David
The price is ₩374,004
₩453,115 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Sanibel Island Beach Resort
Lobby
Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1000)
"Stunning Beach View great Staff "
United States
Robert
The price is ₩503,966
₩612,464 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Tween Waters Island Resort & Spa
Outdoor pool
Casa Ybel Resort

Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
8.8 out of 10, Excellent, (290)
"Room was amazing! Their video on their site is pre Hurricane Ian so don’t expect it to be like that ! Lots of devistation but they are working to bring it back. Most staff was nice , the front office staff were snotty and not helpful at !! Location on the beach is amazing! Sanibel / Captiva have captured my heart and I can’t wait to return. I’d stay there again . "
United States
Arra
The price is ₩676,553
₩754,357 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Casa Ybel Resort
2 outdoor pools, cabanas (surcharge), pool umbrellas
Sundial Beach Resort & Spa

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2584)
"wonderful family friendly and spotless resort"
United States
Mary Anne
The price is ₩531,547
₩671,568 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Sundial Beach Resort & Spa
Exterior
Tarpon Tale Inn

Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 14.8 km from Sanctuary
9.6 out of 10, Exceptional, (392)
"Great staff, close to the beach. Provided beach chairs, umbrella, & beach cart for stay. Highly recommend"
United States
Thomas
The price is ₩323,463
₩360,661 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Tarpon Tale Inn
Luxury Suite, Sea View | Beach/ocean view
Island Inn

Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1123)
"Really nice, updated, and clean room with a screened waterfront balcony in a perfect place on the island (far enough away from the big resorts to be in a quieter area, but close enough to the center area of the island to be convenient). "
United States
Chris
The price is ₩375,138
₩418,280 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Island Inn
Exterior
Matlacha Tiny Village

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (268)
"Very nice place with all necesary accommodations for a Pleasant stay. "
United States
isabel
The price is ₩180,648
₩309,744 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Matlacha Tiny Village
Exterior
Sanibel Inn

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.0 out of 10, Wonderful, (1000)
"Just beautiful! Couldn’t ask for a better stay in Sanibel "
United States
Jennifer Rebecca
The price is ₩510,041
₩652,421 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Sanibel Inn
Exterior
Driftwood Inn

Driftwood Inn

Driftwood Inn
2.0 star property
Mid Island, 13.1 km from Sanctuary
10.0 out of 10, Exceptional, (8)
"Great place to stay on sanibel"
United States
Terri
The price is ₩462,018
₩862,280 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Driftwood Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
Fort Myers featuring a sandy beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Sanibel Historical Museum and Village showing heritage elements

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

J. N. Ding Darling National Wildlife Refuge which includes marine life and dangerous animals

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Periwinkle Way featuring cycling as well as an individual femail

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

Top Sanctuary Hotel Reviews

Sanibel Island Beach Resort

Sanibel Island Beach Resort

10/10 Excellent
"Lovely resort, not too big and not too small. Right on the beach, very nice property. Convenient location to other restaurants, stores, and bike rental. Staff were all super friendly. Restaurant had excellent brekkie and lunch - didn't try dinner. Rooms modern and clean. Would definitely stay again!"
John 3-night trip
Posted 3 days ago
Sanibel Island Beach Resort

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 12 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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