Find hotels in Sanctuary, Sanibel from ₩106,219

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Dates

November 2026

December 2026

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Compare popular hotels in Sanctuary

Property	Property class	Guest rating
Off the Charts Inn & Out Island Resort	2.5 star property	9.6 Exceptional 165 reviews	View
The Anchor Inn	2.0 star property	10.0 Exceptional 85 reviews	View
Tween Waters Island Resort & Spa	3.0 star property	8.6 Excellent 1,000 reviews	View
Sanibel Island Beach Resort	3.0 star property	9.2 Wonderful 2,412 reviews	View
South Seas	3.5 star property	8.4 Very good 1,000 reviews	View

Hotels recommended for families in Sanctuary

A resort with a central pool, multiple lounge areas, and a beach view.

Tween Waters Island Resort & Spa

Captiva

₩369,045 total

includes taxes & fees

Nov 8 - Nov 9

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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A beach with clear turquoise water, a sandy shore, and a weathered driftwood structure.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Sanctuary Hotel Reviews

Tween Waters Island Resort & Spa

Captiva

10/10 Excellent

Jim

A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.

South Seas

Captiva

10/10 Excellent

Our time at South Seas was great! Yes they are still rebuilding some areas and adding on more amenities, but we still had a great time. We stayed at a beach villa which was i. Pristine condition and very comfortable for our family of four. The marina side pools and slides were very fun and in great shape. The service we recieved was top notch. We were also provided a smores kit upon check in for the kids to use at their fire pit at night. Highly recommend this resort on Captiva.

Brandon

A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

Sanibel Island Beach Resort

Mid Island

10/10 Excellent

Linda

A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

Casa Ybel Resort

Mid Island

10/10 Excellent

KnA Dutcher

A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

Off the Charts Inn & Out Island Resort

Saint James City

10/10 Excellent

The property was in the middle of a remodel so there were only 5 rooms available which made it very quiet. The unit was very clean. The amazing thing about the property was the canal in the back. The manatees were swimming around everyday. They were awesome to see. One evening there were dolphins playing in the canal. There was a great restaurant within walking distance that had great food, drinks and live music every night.

Bobbie

A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

Sanibel Inn

East End

10/10 Excellent

Kurt

A spacious living room with a grey sofa, striped armchair, and a woven coffee table. Large windows offer a view of a tropical garden.

Driftwood Inn

Mid Island

10/10 Excellent

The cottage was clean and updated with everything you need, toiletries, kitchen pans and utensils, a full beach cart with everything needed for the beach. I took a few naps in the sun in the hammock. The location is great, an easy block to the beach. The only thing we had difficulty with was the gas grill did not heat up sufficiently to cook burgers. It was an incredible relaxing place for a family vacation, highly recommend it

robin

A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

Pink Shell Beach Resort and Marina

Fort Myers Beach

10/10 Excellent

This is a wonderful place, the adult pool was priceless because of so many children. Food was exceptional for a resort, the only real gripe is the drink prices. 9 bucks for a draft Modelo in a plastic cup. I had two mixed drinks and the wife two Mocktails and it was $60 dollars. I get it, its a resort but they are making a killing off the booze, I noticed many folks just brought their own because of this. Lower the price and you will sell more.

TIMOTHY KEVIN

A large, clear swimming pool with multiple lounge areas and palm trees.

Margaritaville Beach Resort Fort Myers

Fort Myers Beach

10/10 Excellent

Angela

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Caloosahatchee

10/10 Excellent

Lina

A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

Best Western Plus Beach Resort

Fort Myers Beach

10/10 Excellent

newly re-opened, clean, staff was fantastic, pleasant, social, housekeepers were excellent, (thank God for English to Spanish app). clean up from hurricane still going on so beach a little noisy but still relaxing. didn't like that there wasn't a safe in room, beds and linens very comfortable, breakfast was fresh/hot/good selection, great coffee. good company with a parrot named Coco lol. would stay again and recommend

paula

An outdoor patio area with a fire pit table, wicker furniture, and a white fence in the background.

Tarpon Tale Inn

East End

10/10 Excellent

Karen

A balcony with a table and chairs, large windows, and a view of the sea.

The Westin Cape Coral Resort At Marina Village

Pelican

10/10 Excellent

danica

A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

Sundial Beach Resort & Spa

Mid Island

10/10 Excellent

My boyfriend & I stayed for 8 days & 7 nights....The hotel was very nice & the beach was amazing and only steps away from the hotel center. We loved using the kayaks & paddleboards that are included in the stay! We were able to get fresh towels for the beach as often as we liked. Staff was very helpful! The bar & restaurant on site are a little pricey but the food was good. Many restaurants are close by and we explored off the island to eat! Dixie fish co. in Fort Myers beach was one of our...

Anonymous traveler

A balcony with two lounge chairs and a table, overlooking a beach with a clear view of the ocean and distant cityscape.

DiamondHead Beach Resort

Fort Myers Beach

10/10 Excellent

David

Frequently Asked Questions

What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 8 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here.

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Find hotels in Sanctuary, Sanibel from ₩106,219

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Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

2. South Seas

3. Casa Ybel Resort

4. Sanibel Island Beach Resort

5. Marriott Sanibel Harbour Resort & Spa

6. Island Inn

7. Sanibel Inn

8. Sundial Beach Resort & Spa

9. Shalimar Beach Resort

10. Margaritaville Beach Resort Fort Myers

11. Off the Charts Inn & Out Island Resort

12. Pink Shell Beach Resort and Marina

13. The Westin Cape Coral Resort At Marina Village

14. The Anchor Inn

15. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

16. Best Western Plus Beach Resort

17. Driftwood Inn

18. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19. DiamondHead Beach Resort

20. Lani Kai Beachfront Resort

Compare popular hotels in Sanctuary

Hotels recommended for families in Sanctuary

Tween Waters Island Resort & Spa

Where to stay in Sanctuary

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

Tween Waters Island Resort & Spa

10/10 Excellent

Frequently Asked Questions

What is Sanctuary like?

How many hotels are there in the Sanctuary area?

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Sanctuary?

What is there to do around this Sanibel neighborhood?