Find hotels in Santa Maria, Guayaquil from ₩36,631

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Dec 11 - Dec 12
Tomorrow
Dec 12 - Dec 13
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

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Our top choices for Santa Maria hotels

Rooftop bar, alfresco dining, open daily
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (1001)
"Airport shuttle was very convenient "
Canada
Arlene
The price is ₩109,893
₩123,080 total
Jan 1 - Jan 2, 2026
Wyndham Garden Guayaquil
Outdoor pool
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
5.5 km from Santa Maria
9.4 out of 10, Exceptional, (1001)
"Great stay"
United States
Susan
The price is ₩123,080
₩139,051 total
Dec 22 - Dec 23
Holiday Inn Guayaquil Airport by IHG
2 restaurants, breakfast, lunch, dinner served; Regional cuisine
Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (605)
"Very friendly front desk thank you for a comfortable and enjoyable stay. "
United States
Andrew
The price is ₩108,135
₩122,611 total
Dec 21 - Dec 22
Sheraton Guayaquil Hotel
Exterior
TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1000)
"💯"
United States
Sreenidhi
The price is ₩139,564
₩157,191 total
Dec 14 - Dec 15
TRYP by Wyndham Guayaquil Airport
Outdoor pool, sun loungers
Radisson Hotel Guayaquil

Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 4.9 km from Santa Maria
9.2 out of 10, Wonderful, (631)
"Good service "
United States
Genny
The price is ₩140,121
₩157,796 total
Dec 19 - Dec 20
Radisson Hotel Guayaquil
Lobby
DC Suites Aeropuerto

DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
9.0 out of 10, Wonderful, (579)
"Great location and clean hotel"
United States
Elvin
DC Suites Aeropuerto
Lobby
Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (1000)
"Great stay and they were able to accommodate our last minute booking. We had an amazing view of the city and the room was spotless."
United States
Cesar
The price is ₩105,497
₩118,245 total
Dec 27 - Dec 28
Courtyard by Marriott Guayaquil
Exterior
Hotel GH Galeria

Hotel GH Galeria

Hotel GH Galeria
3.5 star property
Downtown Guayaquil, 6.9 km from Santa Maria
8.4 out of 10, Very Good, (393)
"Location "
United States
Marcelo
Hotel GH Galeria
Outdoor pool, open 8:00 AM to 9:00 PM, sun loungers
Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel
4.0 star property
Rocafuerte, 7.9 km from Santa Maria
9.2 out of 10, Wonderful, (987)
"Great place to Stay.!"
United States
Erwin
The price is ₩124,545
₩139,198 total
Dec 14 - Dec 15
Grand Hotel Guayaquil, an Ascend Collection Hotel
Exterior
Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast
3.5 star property
2.9 km from Santa Maria
9.2 out of 10, Wonderful, (46)
"Excelente Todo "
Costa Rica
Cesar
The price is ₩85,717
₩95,754 total
Dec 14 - Dec 15
Iguanazu Bed & Breakfast
Restaurant
Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 8 km from Santa Maria
9.4 out of 10, Exceptional, (272)
"Great location and great hotel "
United States
José
The price is ₩87,914
₩98,903 total
Dec 13 - Dec 14
Ibis Styles El Malecon Guayaquil
Reception
Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 8 km from Santa Maria
9.2 out of 10, Wonderful, (1000)
"Nice place to stay"
United States
Victor
The price is ₩100,222
₩113,907 total
Jan 9 - Jan 10, 2026
Unipark by Oro Verde Hotels
Outdoor pool, sun loungers
Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 7.5 km from Santa Maria
8.6 out of 10, Excellent, (132)
"Excellent location and close to the airport."
United States
Martin Gerardo
Hotel Patrimonial by Greenfield
Presidential Suite, 1 King Bed, Jetted Tub, River View | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.2 out of 10, Wonderful, (1000)
"The hotel and service were great!"
United States
Rolando
The price is ₩161,543
₩181,368 total
Dec 13 - Dec 14
Wyndham Guayaquil Puerto Santa Ana
In-room safe, blackout drapes, soundproofing, iron/ironing board
Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil
3.5 star property
Rocafuerte, 8.1 km from Santa Maria
9.0 out of 10, Wonderful, (71)
"We stayed here twice and both the times to staff was excellent, the property was centrally located, it felt safe, and welcoming. I highly recommend this hotel and felt like it exceeded our expectations."
United States
Ravi
The price is ₩102,198
₩130,748 total
Jan 2 - Jan 3, 2026
Doubletree By Hilton Guayaquil
Garden
Dreamkapture Hostel

Dreamkapture Hostel

Dreamkapture Hostel
2.0 star property
Alborada, 3 km from Santa Maria
8.8 out of 10, Excellent, (19)
"Good Pool !"
Australia
Julie
Dreamkapture Hostel
Executive Suite, Kitchenette, City View | Private kitchen | Microwave, electric kettle, griddle, cookware/dishes/utensils
Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.2 out of 10, Wonderful, (7)
"You can walk to the airport."
United States
Digna
The price is ₩38,903
₩48,427 total
Dec 22 - Dec 23
Suitesecu Rentals Guayaquil
Lobby
Hilton Colon Guayaquil

Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 4.2 km from Santa Maria
8.6 out of 10, Excellent, (813)
"Great room"
United States
Trevor
The price is ₩138,172
₩155,652 total
Dec 27 - Dec 28
Hilton Colon Guayaquil
Children's activities
Oro Verde Guayaquil

Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 6.9 km from Santa Maria
9.4 out of 10, Exceptional, (1003)
"Very good stay , recommend 100%"
United States
Lenin
The price is ₩124,545
₩140,663 total
Dec 21 - Dec 22
Oro Verde Guayaquil
Terrace/patio
Hotel del Parque

Hotel del Parque

Hotel del Parque
4.5 star property
7 km from Santa Maria
9.8 out of 10, Exceptional, (106)
"I love"
United States
Maria
The price is ₩628,588
₩691,447 total
Dec 29 - Dec 30
Hotel del Parque
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town.

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Botanical Garden while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Top Santa Maria Hotel Reviews

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

10/10 Excellent
"Excelente lugar"
Jonatan 2-night trip
Posted 2 days ago
Wyndham Guayaquil Puerto Santa Ana

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Frequently asked questions

What is Santa Maria like?
Travelers are sure to enjoy a stay in Guayaquil's Santa Maria neighborhood.
If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then filter by "fully refundable" to get the best options available in Santa Maria.
Where can I learn more about changing or cancelling my trip to Santa Maria?
For more information about changing or cancelling your trip to Santa Maria, go to https://www.expedia.com/service/.
What can I see and do in this Guayaquil neighborhood?
Salón de Eventos Rubi, City Mall, and Guayaquil Parrot are just a few of the places to visit in and around Santa Maria. La Rotonda Shopping Center and Santa Ana Port are also worth a visit when you're out sightseeing in Guayaquil.