Santo Spirito Vacations

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Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is ₩195,168 per night from Mar 8 to Mar 9
₩195,168
₩238,546 total
Mar 8 - Mar 9
includes taxes & fees
9.8/10 Exceptional! (625 reviews)
Don't worry about anything just book it. Perfect location close to the city centre but less touristy. Buses right outside the door. Quiet and peaceful. Amazing staff, everyone was kind, friendly and professional. Amazing quality rooms, very clean. I was already looking up flights and availability ...

Reviewed on Mar 4, 2026

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
Fully refundableReserve now, pay when you stay
9.2/10 Wonderful! (1,088 reviews)
Beautiful room, very thorough check in with a very nice man who gave us great dining recommendations. We loved having a big fridge. The shower was a bit small but overall we really enjoyed the room.

Reviewed on Feb 26, 2026

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Palazzo Mannaioni Suites
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
The price is ₩171,153 per night from Mar 8 to Mar 9
₩171,153
₩212,121 total
Mar 8 - Mar 9
includes taxes & fees
8.4/10 Very Good! (1,000 reviews)
Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!

Reviewed on Jan 1, 2026

UNA Hotels Vittoria Firenze
See all 495 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santo Spirito vacation package cost?
From just . Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favorite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito vacation package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1,000,000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Center Of Florence.
How far in advance should I book my Santo Spirito vacation?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including vacation rentals like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our vacation packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito vacation package?
If your vacation plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Discover the most popular places to visit in Santo Spirito

Cathedral of Santa Maria del Fiore featuring a city, heritage architecture and a church or cathedral

Cathedral of Santa Maria del Fiore

4.5/5(1,301 reviews)

The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

Cathedral of Santa Maria del Fiore
Uffizi Gallery in Florence in Italy

Uffizi Gallery

4.5/5(1,486 reviews)

Art lovers will be in their element in this famous museum, home to the most extensive and important collection of masterpieces in the world.

Uffizi Gallery
Santa Maria Novella showing a church or cathedral, street scenes and heritage architecture

Basilica of Santa Maria Novella

4.5/5(1,006 reviews)

You can find out about the history of Florence when you stop by Basilica of Santa Maria Novella. Discover the acclaimed art scene and stunning cathedral in this vibrant area.

Basilica of Santa Maria Novella
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.