Santo Spirito Vacations

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Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is ₩173,331 per night from Jan 25 to Jan 26
₩173,331
₩214,557 total
Jan 25 - Jan 26, 2026
includes taxes & fees
9.6/10 Exceptional! (601 reviews)
An excellent experience in an amazing city.

Reviewed on Dec 21, 2025

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
9.2/10 Wonderful! (1,058 reviews)
The room was clean the day we got in, the next days they didn’t enter to clean it and the rules where to leave clean the kitchen, if not, they would charge 50 euros

Reviewed on Dec 12, 2025

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Palazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
The price is ₩144,732 per night from Jan 11 to Jan 12
₩144,732
₩182,964 total
Jan 11 - Jan 12, 2026
includes taxes & fees
9/10 Wonderful! (228 reviews)
Very impressive! We received the notifications few days before arrival to remind us about the date and time. Check-in process was quick and easy, service was great. The staffs were very friendly. Room was large, nice and clean. They kept cleaning daily. Great location and walkable to several attractions ...

Reviewed on Dec 13, 2025

La Torre Del Cestello
See all 488 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santo Spirito vacation package cost?
From just . Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favorite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito vacation package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1,000,000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Center Of Florence.
How far in advance should I book my Santo Spirito vacation?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including vacation rentals like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our vacation packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito vacation package?
If your vacation plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Discover the most popular places to visit in Santo Spirito

Uffizi Gallery

Uffizi Gallery

4.5/5(1,486 reviews)

Art lovers will be in their element in this famous museum, home to the most extensive and important collection of masterpieces in the world.

Uffizi Gallery
Cathedral of Santa Maria del Fiore featuring a city, heritage architecture and a church or cathedral

Cathedral of Santa Maria del Fiore

4.5/5(1,301 reviews)

The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.

Cathedral of Santa Maria del Fiore
Accademia Gallery which includes street scenes as well as a large group of people

Gallery of the Academy of Florence

4.5/5(1,097 reviews)

You can browse the exhibits at Gallery of the Academy of Florence, a museum with a story of its own, during your travels to Florence. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Gallery of the Academy of Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.