Santo Spirito

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A historic church with a dome and bell tower, surrounded by trees and a fountain in a public square.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
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Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
The price is ā‚©455,848 per night from Oct 12 to Oct 13
ā‚©455,848
ā‚©523,206 total
Oct 12 - Oct 13
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (725 reviews)
"Loved the hotel but wished that they would have a small restaurant as the grounds are lovely"

Reviewed on Sep 13, 2026

Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
The price is ā‚©322,705 per night from Sep 24 to Sep 25
ā‚©322,705
ā‚©376,749 total
Sep 24 - Sep 25
includes taxes & fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Cathedral of Santa ...
9.2/10 Wonderful! (316 reviews)
"Location was great, night porter was very helpful"

Reviewed on Sep 14, 2026

La Torre Del Cestello
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
The price is ā‚©207,410 per night from Oct 12 to Oct 13
ā‚©207,410
ā‚©249,924 total
Oct 12 - Oct 13
includes taxes & fees
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
"The entrance, the building, the lobby looked very well and promising. Room was small but ok. The shower was terrible, poor mainteined. Room decoration looked agressive. Breakfast was great. Location little far from downtown"

Reviewed on Sep 6, 2026

UNA Hotels Vittoria Firenze
Casa Santo Nome di GesĆ¹

Casa Santo Nome di GesĆ¹

Piazza del Carmine, 21 Florence FI
The price is ā‚©232,307 per night from Sep 27 to Sep 28
ā‚©232,307
ā‚©274,212 total
Sep 27 - Sep 28
includes taxes & fees
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (382 reviews)
"Beautiful hotel in great location. Staff really helpful with local knowledge. Communal fridge available at reception, which was great for storing drinks."

Reviewed on Aug 27, 2026

Casa Santo Nome di GesĆ¹
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
The price is ā‚©116,502 per night from Oct 11 to Oct 12
ā‚©116,502
ā‚©140,602 total
Oct 11 - Oct 12
includes taxes & fees
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Cathedral of ...
7.8/10 Good! (64 reviews)
"No"

Reviewed on Jul 30, 2026

Hostel Santa Monaca
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is ā‚©370,522 per night from Sep 30 to Oct 1
ā‚©370,522
ā‚©429,347 total
Sep 30 - Oct 1
includes taxes & fees
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
Palazzo Mannaioni Suites
See all 527 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Piazza del Duomo and Piazza di Santa Maria Novella are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

An ornate building with intricate architectural details and a clear blue sky in the background.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito