Santo Spirito
Florence
Visit Santo Spirito
Popular places to visit
Piazza Santo Spirito
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and stunning cathedral in this vibrant area.
Porta Romana
Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the acclaimed art scene and churches in this vibrant area.
Brancacci Chapel
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Uffizi Gallery
Art lovers will be in their element in this famous museum, home to the most extensive and important collection of masterpieces in the world.
Cathedral of Santa Maria del Fiore
The “Saint Mary of the Flower” cathedral and its towering dome have come to symbolize Florence.
Ponte Vecchio
Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.
Santo Spirito Hotel Deals
Hotel Horto Convento
We got upgraded to there other hotel in the same area and it was amazing
Reviewed on Apr 29, 2026
Palazzo Mannaioni Suites
Nice apartment with decent amenities. Bathroom are a little small for a suite. Very noisy at night especially the weekends
Reviewed on Apr 29, 2026
La Torre Del Cestello
Very convenient location, within walking distance of everything. Clean and spacious room with stunning view of the river. Very helpful staff.
Reviewed on May 1, 2026
UNA Hotels Vittoria Firenze
Good
Reviewed on Apr 30, 2026
Foresteria Valdese di Firenze - Casa per Ferie
The staff was amazing.
Reviewed on Apr 10, 2026
Residenza D'Epoca Al Numero 8
great location and customer service was excellent.. little bit hard to find but ask restaurant on same street and they will tell you where it is exactly.
Reviewed on Apr 25, 2026
Other neighborhoods around Santo Spirito
San Frediano
San Frediano is popular for its stunning river views, and if you're looking for more to see and do, you might think about a trip to Piazza Santo Spirito or Boboli Gardens.
Oltrarno
South of the River Arno, this quarter boasts part of Florence's historic center, featuring notable sites like Santo Spirito di Firenze, Palazzo Pitti, Belvedere, and Piazzale Michelangelo.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
San Giovanni
If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.
Historic Centre of Florence
Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.
Duomo
Cathedral of Santa Maria del Fiore and Uffizi Gallery are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.
