A grand church interior with high vaulted ceilings, large columns, and a central altar.

Find hotels in Santo Spirito, Florence

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santo Spirito hotels

1. Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (693 reviews)
"Beautiful, clean, amazing breakfast, really nice staff. 10/10 recommendation"
United States
Jennifer
The price is ₩271,394
₩322,358 total
includes taxes & fees
Aug 11 - Aug 12
Hotel Horto Convento

2. Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1,143 reviews)
"Great location in Florence. The flats were comfortable and with everything básica you need. It is in a quiet street next to the city centre. The staff was very helpuful and we lived all of their recommendations."
United States
Laura
The price is ₩291,011
₩343,937 total
includes taxes & fees
Jul 21 - Jul 22
Palazzo Mannaioni Suites

3. UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze
4.0 star property
Santo Spirito
8.4 out of 10, Very Good, (1,000 reviews)
"Great staff and well located especially for the West Bank of the city. Slightly too far out for the city etc"
United Kingdom
Glenn
The price is ₩137,848
₩175,458 total
includes taxes & fees
Jul 26 - Jul 27
UNA Hotels Vittoria Firenze

4. La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (183 reviews)
"Really nice, handy location"
United Kingdom
Kate
The price is ₩167,822
₩205,026 total
includes taxes & fees
Aug 19 - Aug 20
La Fonderia Firenze

5. AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (233 reviews)
"This was our second time visiting Florence, staying at Astra. We loved the beauty of the rooms and surrounding gardens. The staff were very nice and helpful. It's the perfect blend of amenities and self-service for us. We had a B&B-style breakfast and service with 5-star rooms and vibes."
United Kingdom
Gary
The price is ₩372,814
₩433,921 total
includes taxes & fees
Jul 27 - Jul 28
AdAstra Suites

6. Drom Florence Rooms & Apartments

Drom Florence Rooms & Apartments
Santo Spirito
9.8 out of 10, Exceptional, (151 reviews)
"We had a very nice stay. Claudia was very friendly and service minded The place serves continental breakfast - and is a good idea to supplement it a little bit! Nice and quiet area, where you can walk to most things We can only recommend it Else Marie Hansen May 2026"
Denmark
Else Marie
The price is ₩189,598
₩228,980 total
includes taxes & fees
Aug 12 - Aug 13
Drom Florence Rooms & Apartments

7. 1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (198 reviews)
"Great place, very clean and as described in the listing. It has a good AC for the summer months and I highly recommend it."
United States
Jose Felipe
The price is ₩142,512
₩177,185 total
includes taxes & fees
Aug 2 - Aug 3
1900 Artevita

8. Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (129 reviews)
"Amazing location, charming hotel and great breakfast"
Sweden
Carin
The price is ₩402,403
₩466,468 total
includes taxes & fees
Aug 2 - Aug 3
Oltrarno Splendid

9. La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (279 reviews)
"Great location! Staff was amazing!"
United States
Michelle
The price is ₩186,688
₩229,182 total
includes taxes & fees
Jul 28 - Jul 29
La Torre Del Cestello

10. Casa Santo Nome di Gesù

Casa Santo Nome di Gesù
Santo Spirito
8.8 out of 10, Excellent, (373 reviews)
"The air-conditioning was perfect, it was very quiet there and the room was spotless. The staff was so helpful to me in finding a restaurant and reserving a taxi. Breakfast was excellent and abundant. What a joy to stay there!"
United States
Jacqueline
The price is ₩203,485
₩244,256 total
includes taxes & fees
Aug 1 - Aug 2
Casa Santo Nome di Gesù

11. Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (174 reviews)
"Really beautiful property and wonderful room. Hotel is immaculately clean and we thought the hotel had been renovated to a beautiful finish. We let the hotel know we were staying for our 10 year anniversary, and a bottle of Prosecco was left in our room with a note, which was extremely kind. A great location to stay in, just across the river. Passcode is provided for front door so can come and go as please. Have booked to stay in again in October!"
United Kingdom
Samantha
The price is ₩321,644
₩377,634 total
includes taxes & fees
Aug 4 - Aug 5
Ottantotto Firenze

12. Mamo Florence - Aleardi Roof Apartment

Mamo Florence - Aleardi Roof Apartment
Santo Spirito
10.0 out of 10, Exceptional, (1 review)
"Excelente lugar y relacion precio - estancia"
Mexico
Roberto Carlos
The price is ₩173,168
₩406,616 total
includes taxes & fees
Aug 2 - Aug 3
Mamo Florence - Aleardi Roof Apartment

13. Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103 reviews)
"Beautiful property and wonderful staff."
United States
Brad
The price is ₩830,488
₩937,362 total
includes taxes & fees
Jul 31 - Aug 1
Torre di Bellosguardo

14. Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
9.0 out of 10, Wonderful, (163 reviews)
"Excellent place"
United States
Laura Patricia
The price is ₩175,817
₩217,224 total
includes taxes & fees
Aug 4 - Aug 5
Residenza D'Epoca Al Numero 8

15. Home in Florence

Home in Florence
Santo Spirito
9.0 out of 10, Wonderful, (77 reviews)
"Wonderful stay again here-our second time. Beautifully clean, perfect location and friendly staff-thankyou for another lovely stay!"
United Kingdom
Victoria
The price is ₩137,848
₩172,054 total
includes taxes & fees
Jul 21 - Jul 22
Home in Florence

16. Palazzo Oliveto

Palazzo Oliveto
Santo Spirito
7.6 out of 10, Good, (105 reviews)
"Good location"
France
Leana
The price is ₩92,942
₩122,658 total
includes taxes & fees
Aug 11 - Aug 12
Palazzo Oliveto

17. Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (230 reviews)
"I had a lovely stay! Staff were helpful"
United States
Alloura
The price is ₩111,407
₩142,970 total
includes taxes & fees
Aug 4 - Aug 5
Foresteria Valdese di Firenze - Casa per Ferie

18. Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca
Santo Spirito
9.4 out of 10, Exceptional, (55 reviews)
"lovely hotel - very nice staff and beautiful rooms. could be a little loud at night but not a problem. excellent location, super convenient"
United Kingdom
Hannah
The price is ₩216,852
₩258,959 total
includes taxes & fees
Aug 2 - Aug 3
Palazzo D'Oltrarno - Residenza D'Epoca

19. SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (26 reviews)
"Easy check in and very helpful and polite "
United States
Remi
The price is ₩311,897
₩363,509 total
includes taxes & fees
Jul 26 - Jul 27
SPIRIT OF FLORENCE Boutique Rooms

20. L'Antica Porta Boutique B&B

L'Antica Porta Boutique B&B
Santo Spirito
8.6 out of 10, Excellent, (26 reviews)
"Very goord place to stay"
United States
Victor
The price is ₩162,911
₩199,624 total
includes taxes & fees
Jul 21 - Jul 22
L'Antica Porta Boutique B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Cathedral of Santa Maria del Fiore and Piazza del Duomo are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Signoria and Cathedral of Santa Maria del Fiore are top sights worth seeing.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Find out more about Santo Spirito

Top reasons to visit Santo Spirito

  • Charming Piazza Santo Spirito: A vibrant square perfect for soaking in the local atmosphere, surrounded by cafes and shops.
  • Historical San Spirito Church: A stunning example of Renaissance architecture, rich in history and cultural significance.
  • Culinary Delights: Indulge in local flavors with wine tours and delightful Tuscan cuisine available throughout the neighborhood.
  • Trendy Shopping: Explore quaint streets filled with unique boutiques and hidden gems that showcase local craftsmanship.
  • Welcoming Accommodations: Enjoy a variety of cozy hotels and charming bed & breakfasts that enhance your stay.

Find great hotels near Santo Spirito

Discover the charm of Santo Spirito with a variety of accommodation options, including cozy hotels and inviting bed & breakfasts. Whether you're seeking a pet-friendly stay or a city-themed retreat, you'll find a perfect fit. Experience the unique ambiance of Florence, complete with antique furniture and local attractions like Palazzo Ridolfi and Fra Bartolomeo. Enjoy a memorable vacation tailored to your desires in this vibrant neighborhood of Tuscany.

  • The Social Hub Florence Lavagnini: Situated in the heart of Florence, The Social Hub Florence Lavagnini is a vibrant 4-star hotel that caters to adventurers and business travelers alike. With a stellar guest rating of 9.0 out of 10, this property is just 2km from Santo Spirito and offers a unique blend of city-themed vacation experiences. Guests can enjoy various adventure sports and recreation activities both onsite and nearby, making it an excellent choice for those looking to explore the bustling city. The accommodation features modern amenities designed to foster a social atmosphere, perfect for meeting fellow travelers.
  • B&B Hotel Firenze Pitti Palace al Ponte Vecchio: Located a mere 1km from Santo Spirito, B&B Hotel Firenze Pitti Palace al Ponte Vecchio is a family-friendly 4-star hotel that also enjoys a guest rating of 9.0 out of 10. This charming property is ideal for families seeking an adventurous vacation experience. With amenities like bicycle rentals available nearby, guests can easily explore Florence's picturesque streets. The hotel also offers childcare services, making it convenient for parents traveling with children, ensuring that everyone can enjoy a delightful stay in the heart of Tuscany.
  • Grand Hotel Cavour: With a guest rating of 9.2 out of 10, Grand Hotel Cavour is a distinguished 4-star hotel located 2km from Santo Spirito. This property is particularly suited for families and pet owners, featuring a range of child-friendly amenities such as babysitting services available both onsite and in-room. Additionally, the hotel has a welcoming pet policy, allowing guests to bring their furry companions along. Grand Hotel Cavour combines comfort and convenience, making it a great choice for those traveling with family or pets while exploring the captivating city of Florence.

Where to stay near Santo Spirito

Discover the charming neighborhood of Santo Spirito in Florence, where history and culture come alive. Explore the lively Piazza Santo Spirito, a perfect spot to soak in the local atmosphere. Immerse yourself in the Florentine Renaissance as you wander through its quaint streets, filled with trendy shops and hidden gems. Enjoy a romantic evening or a relaxing day surrounded by friendly locals, making your stay in the heart of Florence an unforgettable experience.

  • Florence: As the heart of Tuscany, Florence is a vibrant city renowned for its rich history, stunning architecture, and cultural treasures. Situated near Santo Spirito, it attracts visitors year-round, with peak seasons in March to April and September. Travelers flock to Florence for its cultural, city, and family experiences. Must-visit highlights include the iconic piazza squares, historic landmarks, and bustling shopping areas. Don't miss the chance to enjoy local theater performances and relax at nearby spas.
  • Duomo: Located a mere 1km from Santo Spirito, the Duomo neighborhood is a must-see for its breathtaking cathedral and vibrant atmosphere. This area experiences moderate seasonal variations in visitor arrivals, peaking from July to September. Duomo offers a blend of culture, family-friendly activities, and city exploration. Discover lively public markets, chic shopping districts, and the enchanting piazza square that encapsulates the essence of Florence's historic charm.
  • San Giovanni: Also just 1km from Santo Spirito, San Giovanni is a lively neighborhood that provides a perfect mix of culture and family experiences. With a similar seasonal visitor pattern as Duomo, the area is buzzing with activity, especially from July to September. Explore local shopping areas and vibrant markets, and take in the sights of its picturesque squares and historic places. San Giovanni is ideal for those looking to immerse themselves in the local lifestyle while enjoying the rich history of Florence.

Things to do near Santo Spirito

Shopping

Santo Spirito offers a vibrant shopping experience with local artisan shops and boutiques. You can explore the bustling Santo Spirito Market for unique souvenirs, crafts, and fresh produce. Nearby, the Oltrarno area features charming stores with handcrafted items that reflect Tuscany's rich culture.

Recreation

In Santo Spirito, the luxurious Palazzo Castri 1874 features a serene wellness center with a range of rejuvenating treatments and a beautiful garden for relaxation. Nearby, the historic Spa at Four Seasons Hotel Firenze offers a tranquil atmosphere and various wellness therapies to enhance your vacation experience.

Adventure

At the Mugello Circuit, located 27km from Santo Spirito, thrill-seekers can experience high-speed motor racing in a vibrant atmosphere. This venue caters to adrenaline enthusiasts, offering various motorsport events and a chance to feel the rush of racing on a world-renowned track.

Nightlife

Santo Spirito buzzes with energy at night, featuring vibrant bars like Il Santo Bevitore for artisanal cocktails and La Cité for a cozy vibe with live music. For a taste of local wine, visit Vini e Vecchi Sapori, where you can unwind with friends and enjoy the lively atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Santo Spirito

Santo Spirito offers a delightful blend of cultural and city-themed experiences, perfect for outdoor enthusiasts and families alike. Visitors can explore the charming Santo Spirito Square and the historic San Spirito church, immersing themselves in the rich history and vibrant atmosphere. With its picturesque piazzas and historic palaces, Santo Spirito promises a memorable vacation filled with cultural discoveries and leisurely strolls through its enchanting streets.

  • Uffizi Gallery: Located 1km from Santo Spirito, the Uffizi Gallery is a renowned art museum showcasing masterpieces from the Renaissance. Visitors can immerse themselves in the rich cultural vibes while exploring works by artists like Botticelli and Michelangelo, making it a highlight for art lovers.
  • Bargello: Just 2km away, the Bargello is another significant art museum, famous for its impressive collection of Renaissance sculpture. The unique atmosphere here allows visitors to appreciate works by Donatello and Michelangelo in an intimate setting, enhancing the cultural experience.
  • Piazza di Santa Maria Novella: Situated 1km from Santo Spirito, this vibrant square is surrounded by stunning architecture and lively cafés, offering a perfect blend of city and cultural vibes. It's an ideal spot to relax and soak in the local atmosphere.

Best time to go to Santo Spirito

The best time to visit Santo Spirito is dependent on what kind of holiday you are seeking. July and August are its hottest month on average. At the time of August, visitor numbers are moderately high and weather is sunny. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January41.4°F (5.2°C)Light RainMostly SunnyModerately LowSlightly Low
February43.0°F (6.1°C)Light RainMostly SunnyModerately LowSlightly Low
March47.8°F (8.8°C)Light RainMostly SunnyAverageAverage
April54.3°F (12.4°C)Light RainMostly SunnyAverageAverage
May60.4°F (15.8°C)Light RainMostly SunnyAverageSlightly High
June69.6°F (20.9°C)Light RainSunnyAverageSlightly High
July75.2°F (24.0°C)No RainSunnyModerately HighAverage
August75.2°F (24.0°C)No RainSunnyModerately HighAverage
September67.3°F (19.6°C)Light RainMostly SunnyModerately HighSlightly High
October58.8°F (14.9°C)Light RainMostly SunnyAverageAverage
November50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly Low
December43.5°F (6.4°C)Light RainMostly SunnyModerately LowAverage

The nearest major airports for your trip to Santo Spirito

Traveling to Santo Spirito in Florence is convenient with several major airports nearby. Florence Airport (FLR-Peretola) is only 5km away, with nearby luxury accommodations like the 5-star Palazzo Montebello and Hotel Lungarno, both offering shuttle services. Bologna Airport (BLQ-Guglielmo Marconi) is 85km from Santo Spirito, with options such as the Grand Hotel Majestic and Starhotels Excelsior, which provide shuttle services as well. Lastly, Pisa Airport (PSA-Galileo Galilei) is 68km away, featuring the 5-star Hotel Pisa Tower Plaza, conveniently located with easy access to the airport. Each of these airports offers great connectivity to the beautiful city of Florence.

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighborhood known for its beautiful river views. Be sure to check out Piazza Santo Spirito and Santo Spirito Basilica as part of your Santo Spirito travel plans.
What's the best accommodation in Santo Spirito?
Based on our traveler data, Hotel Horto Convento is one of the top choices for your stay in Santo Spirito. This hotel is a short 14-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and a bar. Other good options for your stay in the neighborhood include La Torre Del Cestello and UNA Hotels Vittoria Firenze.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 521 hotels and other accommodations in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals in Santo Spirito.
Where can I learn more about changing or cancelling my trip to Santo Spirito?
To find more details about updating your trip to Santo Spirito or cancelling it, head over to our customer service page.
What can I see and do in this Florence neighborhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighborhood, Piazza Santo Spirito and Santo Spirito Basilica are some other places worth a visit. Favorite places to visit in the surrounding area include Piazza di Santa Maria Novella, Piazza della Signoria, and Cathedral of Santa Maria del Fiore. When you're sightseeing in Florence, Piazza del Duomo and Piazza del Carmine are also worth a stop.