Santo Spirito

Florence

Brancacci Chapel which includes heritage architecture, a church or cathedral and a sunset
Brancacci Chapel which includes heritage architecture and a church or cathedral
Brancacci Chapel featuring heritage elements
Brancacci Chapel which includes a church or cathedral and heritage architecture
Arcetri which includes a city and landscape views

Popular places to visit

Piazza Santo Spirito

Piazza Santo Spirito

Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and stunning cathedral in this vibrant area.

Piazza Santo Spirito
Porta Romana

Porta Romana

Find out about the history of Arcetri when you take a trip to Porta Romana. Amble around this vibrant area's riverfront or experience its fascinating museums.

Porta Romana
Brancacci Chapel which includes heritage architecture and a church or cathedral

Brancacci Chapel

A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.

Brancacci Chapel
Uffizi Gallery

Uffizi Gallery

Art lovers will be in their element in this famous museum, home to the most extensive and important collection of masterpieces in the world.

Uffizi Gallery
Ponte Vecchio which includes a bridge and a river or creek

Ponte Vecchio

Take a trip over Florence’s iconic bridge, spared by the Nazis for its beauty and home to jewelers for more than four centuries.

Ponte Vecchio
Piazza di Santa Maria Novella which includes a garden, heritage architecture and a church or cathedral

Piazza di Santa Maria Novella

After visiting Piazza di Santa Maria Novella, make a plan to see the other sights and activities in Florence. Stroll along the riverfront or experience the fascinating museums in this vibrant area.

Piazza di Santa Maria Novella

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13, Florence, FI
The price is ₩170,932 per night from Dec 9 to Dec 10
₩170,932
₩211,587 total
Dec 9 - Dec 10
includes taxes & fees
Stay at this 4-star hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.6/10 Exceptional! (588 reviews)
Great hotel with wonderful atmosphere and well kept facilities.

Reviewed on Oct 28, 2025

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r, Florence, FI
Stay at this 4-star residence in Florence. Enjoy free WiFi, concierge services, and satellite TV channels. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,046 reviews)
Everything A Okay, and then some. Staff is wonderfully helpful with cool places to eat, from croissants to pizza, to wild boar pasta. View, superb.

Reviewed on Nov 5, 2025

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Palazzo Mannaioni Suites
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59, Florence, FI
The price is ₩170,550 per night from Nov 21 to Nov 22
₩170,550
₩211,267 total
Nov 21 - Nov 22
includes taxes & fees
Stay at this 4-star boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (987 reviews)
Super nice reception staffs, everyone is so friendly and welcoming. But don’t like the red room decoration.

Reviewed on Nov 5, 2025

UNA Hotels Vittoria Firenze
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8, Florence, FI
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery ...
9/10 Wonderful! (219 reviews)
Staff were super friendly, the room and the view from the room were gorgeous, location was perfect. I would happily stay again and recommend to anyone heading to Florence for holiday.

Reviewed on Nov 6, 2025

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La Torre Del Cestello
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6, Florence, FI
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Uffizi Gallery ...
8/10 Very Good! (60 reviews)
Clean room , friendly staffs & very accessible to any amenities . Separate toilet , shower & lavatory specific for women only , away from male rooms & toilets . Have ample space for kitchen with utensils, tables & chairs . Highly recommended ! Love it

Reviewed on Sep 18, 2025

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Hostel Santa Monaca
Oltrarno Splendid

Oltrarno Splendid

Via dei Serragli 7, Florence, FI
The price is ₩287,793 per night from Dec 12 to Dec 13
₩287,793
₩340,134 total
Dec 12 - Dec 13
includes taxes & fees
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.8/10 Exceptional! (95 reviews)
Amazing and kind staff. Delicious breakfast.

Reviewed on Oct 18, 2025

Oltrarno Splendid
See all 466 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Santo Spirito

Brancacci Chapel which includes a church or cathedral and heritage architecture

San Frediano

San Frediano is popular for its stunning river views, and if you're looking for more to see and do, you might think about a trip to Piazza Santo Spirito or Santo Spirito Basilica.

San Frediano
Arcetri which includes a river or creek, a sunset and a bridge

Oltrarno

4.5/5(529 area reviews)

South of the River Arno, this quarter boasts part of Florence's historic center, featuring notable sites like Santo Spirito di Firenze, Palazzo Pitti, Belvedere, and Piazzale Michelangelo.

Oltrarno
Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes

Santa Maria Novella

4.5/5(1,057 area reviews)

Enjoy the popular shops in Santa Maria Novella. The New Florence Opera House is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Maria Novella
Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.

San Giovanni
Duomo featuring heritage architecture and street scenes as well as a small group of people

Duomo

5/5(2,214 area reviews)

Cathedral of Santa Maria del Fiore and Uffizi Gallery are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

Duomo
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Historic Centre of Florence

Santo Spirito