Find hotels in Seneca, SC from ₩91,564

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 6 - Dec 7
Tomorrow
Dec 7 - Dec 8
Next weekend
Dec 12 - Dec 14
In two weeks
Dec 19 - Dec 21

Filter by

Guest rating
Guest rating
Star rating

Compare 1,645 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 star property
Seneca
9.0 out of 10, Wonderful, (1001)
"Overall great stay."
United States
Daniel
The price is ₩160,558
₩199,313 total
includes taxes & fees
Dec 7 - Dec 8
Lakeside Lodge Clemson
Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 star property
Downtown
8.0 out of 10, Very Good, (664)
"Friendly check in, clean room."
United States
connie
The price is ₩108,263
₩127,862 total
includes taxes & fees
Dec 14 - Dec 15
Quality Inn Seneca Clemson Area US-123
Lobby
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 star property
Seneca
8.4 out of 10, Very Good, (638)
"The stay was amazing "
United States
Tabatha
The price is ₩131,466
₩144,612 total
includes taxes & fees
Dec 25 - Dec 26
Best Western Seneca-Clemson
Lobby
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 star property
Seneca
9.2 out of 10, Wonderful, (788)
"Staff was very friendly. Everything was very clean. Very quite in room"
United States
Dianna
The price is ₩140,230
₩154,254 total
includes taxes & fees
Dec 22 - Dec 23
Tru by Hilton Seneca Clemson
Exterior
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2.0 star property
Seneca
9.8 out of 10, Exceptional, (49)
"The place was absolutely magnificent."
United States
David
The price is ₩131,098
₩209,021 total
includes taxes & fees
Dec 8 - Dec 9
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Balcony
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 star property
Seneca
9.4 out of 10, Exceptional, (204)
"Nice hotel by the lake"
United States
Mike
The price is ₩169,396
₩186,335 total
includes taxes & fees
Dec 30 - Dec 31
Fairfield Inn & Suites Seneca Clemson Univ Area
Exterior
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 star property
Seneca
9.2 out of 10, Wonderful, (660)
"Great place to stay"
United States
Jose
The price is ₩152,210
₩167,430 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn & Suites Seneca-Clemson Area
Room, 1 King Bed, Non Smoking | Desk, free cribs/infant beds, rollaway beds, free WiFi
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
Seneca
6.8 out of 10, (719)
"Room was clean. Quiet place to rest. Lisa at the front desk was very helpful and very nice. "
United States
Teresa
The price is ₩98,913
₩108,805 total
includes taxes & fees
Dec 24 - Dec 25
Days Inn by Wyndham Seneca / Clemson Area
Free daily continental breakfast
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2.0 star property
Anderson
7.8 out of 10, Good, (1000)
"Very nice we'll stay there again"
United States
Michael
The price is ₩92,652
₩102,845 total
includes taxes & fees
Dec 8 - Dec 9
Days Inn by Wyndham Anderson
Exterior
Hampton Inn Hartwell

Hampton Inn Hartwell

2.5 star property
Hartwell
9.2 out of 10, Wonderful, (333)
"Great stay!"
United States
Daniel
The price is ₩143,736
₩172,662 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn Hartwell
Lobby
Baymont by Wyndham Easley/Greenville

Baymont by Wyndham Easley/Greenville

2.5 star property
Easley
7.4 out of 10, Good, (744)
"Room was nice, and the staff was very friendly. "
United States
Gary
The price is ₩110,476
₩122,629 total
includes taxes & fees
Dec 7 - Dec 8
Baymont by Wyndham Easley/Greenville
Free continental breakfast on weekdays
Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla

2.0 star property
Walhalla
7.6 out of 10, Good, (174)
"Comfortable, clean, convenient and well located near nature interests in the area. Perfect for our stay to do white water raft on the Chatooga. Great shower and comfortable beds."
United States
Cheryl
The price is ₩100,150
₩111,667 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Rodeway Inn & Suites Walhalla
Exterior
Holiday Inn Express Anderson by IHG

Holiday Inn Express Anderson by IHG

2.5 star property
Anderson
8.6 out of 10, Excellent, (383)
"Convenient location to I-85, quiet with nice parking area "
United States
Nancy
The price is ₩154,666
₩171,680 total
includes taxes & fees
Dec 20 - Dec 21
Holiday Inn Express Anderson by IHG
Terrace/patio
Hampton Inn & Suites Lavonia

Hampton Inn & Suites Lavonia

2.5 star property
Lavonia
9.0 out of 10, Wonderful, (375)
"We felt safe staying in the hotel. It was quiet and the staff were so kind and helpful to us. "
United States
Nancy Barbara
The price is ₩153,193
₩183,537 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hampton Inn & Suites Lavonia
Lobby
Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

2.0 star property
Anderson
8.2 out of 10, Very Good, (1001)
"Room was clean, staff was nice! "
United States
Martina
The price is ₩117,693
₩130,639 total
includes taxes & fees
Dec 28 - Dec 29
Microtel Inn & Suites by Wyndham Anderson/Clemson
Reception
Quality Inn Clemson near University

Quality Inn Clemson near University

2.5 star property
Anderson
7.0 out of 10, Good, (888)
"Bueno was "
Mexico
Alejandro
The price is ₩67,330
₩74,736 total
includes taxes & fees
Dec 18 - Dec 19
Quality Inn Clemson near University
Exterior
Hilton Garden Inn Anderson

Hilton Garden Inn Anderson

3.0 star property
Anderson
9.0 out of 10, Wonderful, (672)
"Clean Room "
United States
Cynthia
The price is ₩152,014
₩168,736 total
includes taxes & fees
Dec 13 - Dec 14
Hilton Garden Inn Anderson
Standard Room, 2 Queen Beds, Non Smoking | Free WiFi, bed sheets
Rodeway Inn

Rodeway Inn

2.0 star property
Anderson
7.8 out of 10, Good, (316)
"Nice beds"
United States
Tammy
The price is ₩88,495
₩98,229 total
includes taxes & fees
Dec 7 - Dec 8
Rodeway Inn
Standard Cabin, Courtyard View | Premium bedding, in-room safe, laptop workspace, free WiFi
Carolina Camp Cedar

Carolina Camp Cedar

3.5 star property
Pickens
The price is ₩141,586
₩293,034 total
includes taxes & fees
Dec 7 - Dec 8
Carolina Camp Cedar
Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix
Clemson Memorabilia House

Clemson Memorabilia House

3.0 star property
Clemson
9.8 out of 10, Exceptional, (8)
"We enjoyed our stay, it was the perfect size for our family of four. "
United States
Ashley
The price is ₩122,260
₩340,089 total
includes taxes & fees
Dec 10 - Dec 11
Clemson Memorabilia House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most.

Downtown

While visiting Downtown, you might make a stop by sights like Seneca Historic District and The Gauntlet.

Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.

Pine Ridge Point

While Pine Ridge Point isn't home to many top sights, Lake Keowee and World of Energy are some notable places to visit nearby.

Indian Oaks

While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like The Gauntlet and Seneca Historic District.

Keowee Plantation

When in Keowee Plantation, you can plan a visit to Seneca Historic District and Keowee Reservoir, some noteworthy sights in the nearby area.

Stay near popular Seneca attractions

Lovely shot of the Blue Ridge Mountains in the distance, with a rural pasture in the foreground, in late summer when the grass is starting to turn yellow and brown. Upstate South Carolina scene.

Blue Ridge Field

This historic park honors African-American education in Oconee County on the former Blue Ridge High School football grounds. Stroll the paved loop trail and explore community gardens in this peaceful green space.
See properties
High Shoals Falls in South Mountains State Park

High Falls County Park

Nestled along Lake Keowee with the Blue Ridge Mountains as backdrop, High Falls County Park offers pristine swimming and camping spots. Reserve waterfront campsites early to enjoy the park's serene natural setting.
See properties

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

See all hotels in Seneca
Lake Keowee South Carolina

Top Seneca Hotel Reviews

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"Great staff, clean rooms and good location made our stay perfect!"
Cynthia 2-night trip
Posted 5 days ago
The Shepherd Hotel Downtown Clemson

More cheap stays in Seneca

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
The price is ₩92,652 per night from Dec 8 to Dec 9
₩92,652
₩102,845 total
Dec 8 - Dec 9
includes taxes & fees
7.6/10 Good! (1,026 reviews)

Frequently asked questions

Where is the best place for a stay in Seneca?
Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel offers free breakfast and free parking. Traveler reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.
If I need to cancel my hotel reservation in Seneca, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.
Where can I learn more about changing or cancelling my trip to Seneca?
To find more details about updating your trip to Seneca or cancelling it, click here.
What's the best place to stay for a family vacation to Seneca?
Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Attractions in the area like Ultimate Action Sports are also fun for the whole family. Find more child-friendly accommodations in Seneca.
What's the best LGBTQ-friendly place to stay in Seneca?
Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Tru by Hilton Seneca Clemson is another good choice for your stay. See all available hotels listed as LGBTQ-friendly in Seneca.
What's the best pet-friendly accommodation in Seneca?
Quality Inn Seneca Clemson Area US-123 is a top hotel for people traveling with their pets, and offers a seasonal outdoor pool and free WiFi for its human guests. Other good choices to stay with your pet include Lakeside Lodge Clemson and Days Inn by Wyndham Seneca / Clemson Area. See more pet-friendly hotel accommodations in Seneca.
What are some hotels with pools in Seneca?
Quality Inn Seneca Clemson Area US-123: Features daily, a seasonal outdoor pool, and free self parking. Lakeside Lodge Clemson and Days Inn by Wyndham Seneca / Clemson Area are two additional hotels with an onsite pool. View all hotels with pools in Seneca.
What is the best accommodation for staying close to Greenville-Spartanburg International Airport (GSP)?
Wyndham Garden Greenville Airport is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and a restaurant. It's located 3.8 mi (6.1 km) from Greenville-Spartanburg Intl. Airport. Other good options near the airport include Best Western Greenville Airport Inn and Extended Stay America - Greenville - Airport.
What is staying in Seneca like?
Visitors to Seneca are sure to enjoy the sporting events, lakeside setting, and university setting. Welcoming and scenic, this city also attracts tourists with its coffeehouses. In Seneca, there are 290 hotels and other accommodations to choose from. Find out more about Seneca.
What should I do while I'm visiting Seneca?
Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Lake Keowee, Lake Hartwell, and Keowee Reservoir. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Check out what more to see and do in Expedia's Seneca guide.
What's the weather like in Seneca?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Seneca is 62 inches.

Explore a world of travel with Expedia