![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
Southeast Missouri Vacations
Book a Hotel + Flight or Car together to unlock savings
Plan, book, travel with confidence
Better together
Save up to ₩9,995 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Southeast Missouri Hotel Deals
![Auburn Place Hotel And Suites](https://images.trvl-media.com/lodging/1000000/980000/980000/979972/ee364310_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Auburn Place Hotel And Suites
3265 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is ₩95,228 per night from Jul 18 to Jul 19
₩95,228
per night
Jul 18 - Jul 19
8.6/10 Excellent! (1,004 reviews)
"Was very clean. Super friendly staff!"
Reviewed on Jun 15, 2024
![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/f23ff087_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is ₩98,059 per night from Jun 18 to Jun 19
₩98,059
per night
Jun 18 - Jun 19
7/10 Good! (1,005 reviews)
"Extremely quiet"
Reviewed on Jun 13, 2024
![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
The price is ₩108,955 per night from Jun 18 to Jun 19
₩108,955
per night
Jun 18 - Jun 19
8/10 Very Good! (1,004 reviews)
"This hotel was conveniently located to the highway. Check-in was easy. Nothing fancy, but it was a bed to sleep in on our late check-in and early check-out."
Reviewed on Jun 12, 2024
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Discover the most popular places to visit in Southeast Missouri
Meramec Caverns
5/5(21 reviews)
Explore the great outdoors at Meramec Caverns, a lovely green space in Sullivan. While in this family-friendly area, you can enjoy the coffeehouses.
Elephant Rocks State Park
5/5(13 reviews)
Explore the great outdoors at Elephant Rocks State Park, a lovely green space in Ironton. Make some time to visit the shops while you're in the area.
Ohio River
Commune with nature and explore the great outdoors at Ohio River during your travels in Valley Station. While you're in the area, wander around the parks.
Other vacations you might like
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.