Find Luxury Hotels in Southern Indiana

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Our top choices for Southern Indiana luxury hotels

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,008 reviews)
"Quiet comfortable luxurious rooms and terrific staff."
United States
Jesse
The price is ₩234,647
₩276,083 total
includes taxes & fees
May 24 - May 25
The Grady

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,231 reviews)
  • cleanliness
    Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.
"One of the best hotels I have stayed at! he ambiance matched the quality and the kindness of the staff and the food and drinks.It was definitely a special place "
United States
Patrick
The price is ₩321,994
₩378,863 total
includes taxes & fees
Jun 18 - Jun 19
The Brown Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,885 reviews)
"Really luxurious and amazing"
United States
Mary
The price is ₩286,217
₩336,754 total
includes taxes & fees
Jun 1 - Jun 2
Omni Louisville Hotel

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (688 reviews)
"The inn was so beautiful, every room had a sense of luxury but not over done."
United States
John and Kathy
The price is ₩125,969
₩142,345 total
includes taxes & fees
May 24 - May 25
The Pepin Mansion Historic B&B

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.
"If you love modern art and a bit of whimsy on top of comfortable beds and a fantastic bathroom, you’ll love 21c!"
United States
Laura
The price is ₩240,485
₩290,440 total
includes taxes & fees
Jun 21 - Jun 22
21c Museum Hotel Louisville

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (466 reviews)
"Great service, fantastic food and amenities, a luxury experience and clean facilities."
United States
Michelle
The price is ₩288,492
₩339,440 total
includes taxes & fees
Jun 7 - Jun 8
Hotel Distil, Autograph Collection

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (108 reviews)
"The hotel is gorgeous and feels so luxurious."
United States
Alexis
The price is ₩293,372
₩345,181 total
includes taxes & fees
May 27 - May 28
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,173 reviews)
  • cleanliness
    Upscale riverside hotel features panoramic views, spa services, and gourmet dining in downtown Louisville.
"If you stay in Louisville this is a must stay absolutely amazing place to stay easy access to everything especially the yum center this is luxury at its best and the restaurants in the hotel are wonderful"
United States
kimberly
The price is ₩231,279
₩272,131 total
includes taxes & fees
May 22 - May 23
Galt House Hotel Trademark Collection by Wyndham

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Historic elegance meets modern luxury downtown, with pillowtop beds, designer toiletries, and 24-hour service.
"Seemed like a very luxurious hotel from the 1940s"
United States
David L
The price is ₩227,761
₩267,969 total
includes taxes & fees
Jun 4 - Jun 5
Seelbach Hilton Louisville Downtown

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,000 reviews)
"Convenient and great view."
United States
Kristi
The price is ₩281,936
₩331,726 total
includes taxes & fees
Jun 21 - Jun 22
Louisville Marriott Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southern Indiana Hotel Reviews