A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Luxury Hotels in Southern Indiana

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Tonight
Sep 25 - Sep 26
Tomorrow
Sep 26 - Sep 27
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Southern Indiana luxury hotels

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.
A lobby with a marble floor, a reception desk, and a large chandelier.

1. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
₩381,178
₩448,493 total
includes taxes & fees
Oct 14 - Oct 15
Omni Louisville Hotel
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A bar with shelves of liquor bottles and a bartender preparing drinks.
An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

2. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville
₩335,196
₩394,392 total
includes taxes & fees
Oct 11 - Oct 12
Hotel Distil, Autograph Collection
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".
A building with a sign reading "THE GRADY" at the entrance.
A modern restaurant interior with a staircase, round tables, and a brick wall.

3. The Grady

The Grady
Downtown Louisville
₩238,703
₩280,856 total
includes taxes & fees
Oct 11 - Oct 12
The Grady
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A reception area with marble counters, modern pendant lighting, and potted orchids.
A spacious lobby with a bar area, seating arrangements, and a visible kitchen bar.
A modern bar area with glass partitions, bar stools, and a variety of bottles.

4. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville
₩292,355
₩343,985 total
includes taxes & fees
Oct 12 - Oct 13
Louisville Marriott Downtown
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern hotel room with a large bed, a city view, and a unique headboard design.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

5. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville
₩289,952
₩341,156 total
includes taxes & fees
Oct 11 - Oct 12
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

6. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.
₩219,457
₩265,041 total
includes taxes & fees
Oct 26 - Oct 27
21c Museum Hotel Louisville
A historic hotel with ornate architecture, a grand entrance, and a red carpet leading to the doors.
A bakery display with pastries and bread, a coffee station, and a Christmas tree in the background.
A grand staircase with ornate railings and a marble floor, leading to a high-ceilinged lobby with decorative moldings and a chandelier.
A grand lobby with marble floors, a staircase, and a reception desk.

7. Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
Downtown Louisville
  • Historic elegance meets modern luxury downtown, with pillowtop beds, designer toiletries, and 24-hour service.
₩262,649
₩309,032 total
includes taxes & fees
Oct 4 - Oct 5
Seelbach Hilton Louisville Downtown
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.
An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.
A modern hotel room with a living area, a dining area, and a bedroom.
A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

8. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
Downtown Louisville
  • Upscale Louisville hotel features concierge, gourmet dining, and spacious suites with living areas.
₩211,698
₩249,083 total
includes taxes & fees
Oct 18 - Oct 19
Embassy Suites Louisville Downtown
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand lobby with ornate ceiling, large windows, and classic furniture.

9. The Brown Hotel

The Brown Hotel
Downtown Louisville
  • Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.
₩193,524
₩227,710 total
includes taxes & fees
Sep 29 - Sep 30
The Brown Hotel
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

10. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Upscale riverside hotel features panoramic views, spa services, and gourmet dining in downtown Louisville.
₩205,334
₩241,595 total
includes taxes & fees
Oct 26 - Oct 27
Galt House Hotel Trademark Collection by Wyndham
View all properties

Top Southern Indiana Hotel Reviews

Howard Johnson by Wyndham Evansville East

Howard Johnson by Wyndham Evansville East

10/10 Excellent
"The pool was great. The place is nice and well maintained."
Bryce 1-night trip
Posted 2 days ago
Howard Johnson by Wyndham Evansville East
Hyatt Select Louisville North

Hyatt Select Louisville North

8/10 Good
"Breakfast is not a real buffet more like a continental, which is fine for me I just need coffee in the morning. The room was nice and clean. I was on the first floor by the elevator so it was a lot of opening of doors and noise other then that I would have given it a 5/5"
Louis 1-night trip
Posted 11 days ago
Hyatt Select Louisville North

Explore a world of travel with Expedia