A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Luxury Hotels in Southern Indiana

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Tonight
Sep 28 - Sep 29
Tomorrow
Sep 29 - Sep 30
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Southern Indiana luxury hotels

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A lobby with a marble floor, a reception desk, and a large chandelier.

1. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
₩276,057
₩324,810 total
includes taxes & fees
Oct 30 - Oct 31
Omni Louisville Hotel
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A bar with shelves of liquor bottles and a bartender preparing drinks.
An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

2. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville
₩356,296
₩419,217 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Distil, Autograph Collection
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".
A building with a sign reading "THE GRADY" at the entrance.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

3. The Grady

The Grady
Downtown Louisville
₩236,623
₩278,411 total
includes taxes & fees
Oct 11 - Oct 12
The Grady
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern hotel room with a large bed, a city view, and a unique headboard design.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

4. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville
₩288,529
₩339,484 total
includes taxes & fees
Oct 11 - Oct 12
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A spacious lobby with a bar area, seating arrangements, and a visible kitchen bar.
A modern hotel room with a large window offering a city view, a cozy seating area with a sofa and chairs, a dining table with lamps, and a wooden floor.
A modern bar area with glass partitions, bar stools, and a variety of bottles.

5. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville
₩290,920
₩342,296 total
includes taxes & fees
Oct 12 - Oct 13
Louisville Marriott Downtown
A historic hotel with ornate architecture, a grand entrance, and a red carpet leading to the doors.
A spacious living room with a fireplace, wooden paneling, a television, and a blue sofa.
A bakery display with pastries and bread, a coffee station, and a Christmas tree in the background.
A grand lobby with marble floors, a staircase, and a reception desk.

6. Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
Downtown Louisville
  • Historic elegance meets modern luxury downtown, with pillowtop beds, designer toiletries, and 24-hour service.
₩253,292
₩298,024 total
includes taxes & fees
Oct 5 - Oct 6
Seelbach Hilton Louisville Downtown
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

7. The Brown Hotel

The Brown Hotel
Downtown Louisville
  • Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.
₩181,784
₩213,875 total
includes taxes & fees
Oct 29 - Oct 30
The Brown Hotel
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A steam fountain in a brick alleyway.

8. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.
₩229,041
₩276,261 total
includes taxes & fees
Oct 26 - Oct 27
21c Museum Hotel Louisville
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

9. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Upscale riverside hotel features panoramic views, spa services, and gourmet dining in downtown Louisville.
₩203,652
₩239,616 total
includes taxes & fees
Oct 28 - Oct 29
Galt House Hotel Trademark Collection by Wyndham
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.
A bedroom with a bed, a chair, a TV, and a window with curtains.
A brightly lit grocery store with yellow shelving and a central checkout counter.

10. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
Downtown Louisville
₩205,819
₩242,166 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Genevieve part of JdV by Hyatt
View all properties

Top Southern Indiana Hotel Reviews

Explore a world of travel with Expedia