A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Luxury Hotels in Southern Indiana

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Tonight
Oct 26 - Oct 27
Tomorrow
Oct 27 - Oct 28
This weekend
Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

Our top choices for Southern Indiana luxury hotels

A classical gold statue in front of a multi-story building with large windows and a brick facade.
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A steam fountain in a brick alleyway.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

1. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.
₩201,295
₩243,459 total
includes taxes & fees
Nov 22 - Nov 23
21c Museum Hotel Louisville
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

2. The Brown Hotel

The Brown Hotel
Downtown Louisville
  • Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.
₩178,882
₩210,464 total
includes taxes & fees
Nov 23 - Nov 24
The Brown Hotel
A grand entrance with a staircase leading to a door, flanked by two lamp posts and a bench.
A marble countertop with a tray of colorful glassware, a bottle, and two glasses. A framed painting hangs above, and two lamps are on either side.
A grand hallway with a wooden floor, a staircase, a chandelier, and a large mirror.
A covered porch with a brick wall, a wooden door, and a hanging light fixture.

3. The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
New Albany
₩133,486
₩150,840 total
includes taxes & fees
Oct 27 - Oct 28
The Pepin Mansion Historic B&B
A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.
A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.
A covered outdoor seating area with wicker furniture and a wooden railing.

4. Louisville Bourbon Inn

Louisville Bourbon Inn
Old Louisville
  • Luxurious bourbon country retreat offers elegant rooms with Egyptian cotton sheets and champagne service just minutes from downtown.
₩369,142
₩428,462 total
includes taxes & fees
Oct 27 - Oct 28
Louisville Bourbon Inn
A wooden deck with a table, chairs, and a lantern.
A large, historic house with a green roof, multiple chimneys, and a prominent front porch.
A traditional room with a sofa, armchairs, a coffee table, and a sideboard.
A grand staircase with dark wood railings and a chandelier.

5. Inn at Woodhaven

Inn at Woodhaven
St. Matthews
₩315,954
₩366,734 total
includes taxes & fees
Nov 1 - Nov 2
Inn at Woodhaven
A brick house with a covered porch and a gravel driveway leading to it.
A modern kitchen with white cabinets, a wooden dining table, and a ceiling fan.
A hot tub with a cover, surrounded by a garden with a paved area.
A bedroom with a bed, a ceiling fan, a TV, and a window with curtains.

6. Creation Museum Hot Tub 4BR for 10

Creation Museum Hot Tub 4BR for 10
Burlington
₩393,857
₩775,542 total
includes taxes & fees
Nov 1 - Nov 2
Creation Museum Hot Tub 4BR for 10
View all properties

Top Southern Indiana Hotel Reviews

Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

10/10 Excellent
"Clean,breakfast and right off the interstate. Local restaurants and gas stations."
Doug 1-night trip
Posted 2 hours ago
Hampton Inn New Albany Louisville West
Hampton Inn Evansville/Airport

Hampton Inn Evansville/Airport

10/10 Excellent
"H"
robert 1-night trip
Posted 6 days ago
Hampton Inn Evansville/Airport

Explore a world of travel with Expedia